Research areas are in biology and neogenesis of human and mouse pancreatic islets and beta cells; diabetes/metabolism and glucose homeostasis; metabolism and cancer; and reproduction, infertility, and premature ovarian failure.
My research group is focused on identification of new sources for pancreatic beta cells through regeneration and reprogramming. We have identified growth factors that control formation of new beta cells from other islet cells. Therapeutics based on this research, such as neutralizing antibodies, are being explored as treatments for both type 1 and type 2 diabetes.
Activin is a growth factor in the TGFbeta superfamily that is regulated by antagonists such as follistatin like-3 (FSTL3). FSTL3 knockout mice have enlarged islets with more beta cells and improved glucose homeostasis. We determined that these extra beta cells do not arise from proliferation, but rather appear to form via conversion of other islet cells types, mainly alpha cells. While the mechanisms for this type of conversion are a major area of research, we found that KO mice have more of these converted beta cells than wild type mice suggesting that the process is both normal and enhanced by activin. This suggests that treatments which inhibit FSTL3 or enhance activin might be useful as novel therapies for diabetes where replacement of lost beta cells is essential.
These mice also had reduced visceral fat and improved glucose homeostasis. Since obesity has been linked to cancer risk, particularly for breast cancer, possibly via alteration in hormone levels, it is also possible that FSTL3 inhibitors could be useful for reducing abdominal fat and thus, reduce cancer risk. Connections between obesity, metabolism, endocrinology and cancer are being investigated through collaborations with Drs. Jerry and Dunphy.
Learn more at www.vasci.umass.edu/research-faculty/alan-l-schneyer
- BS University of Pennsylvania, 1976
- MS University of Miami, 1980
- PhD University of Miami, 1983
- Postdoctoral Training: Albany Medical College, 1984-1986