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Agnès Lacreuse

Associate Professor

Sex steroid hormones have widespread effects on brain structure and function, and affect behavior, mood and cognition. The main objective of our research is to understand the consequences of declining sex hormones, in particular estradiol and testosterone, for neurocognitive functioning in aging males and females. Specifically, our studies seek to determine whether the loss of sex hormones that occurs during aging exacerbates cognitive impairment and whether hormonal replacement therapy is an efficient intervention against age-related cognitive decline. We use primate models of human aging to address these questions.

Current Research
Two main projects are currently taking place in the lab. A longitudinal study seeks to identify the biological correlates of sex differences in cognitive and brain aging, using behavioral, physiological and neuroimaging (fMRI) techniques. A second project aims to understand the relationships between estrogen loss, sleep disturbances and cognitive impairment in a primate model of menopause.

Academic Background

  • PhD Université Paul Sabatier, Toulouse, France,1994
  • Postdoctoral Training: University of Georgia, 1995; Emory University, 1997
  • Postdoctoral Training: Yerkes Natl Primate Res Ctr, Emory University, 1997-2002
  • Res Assistant Professor, Yerkes Natl Primate Res Ctr, Emory University 2002-2006
  • Assistant Professor, University of Massachusetts, 2006-2012
  • Associate Professor, University of Massachusetts, 2012-present
Lacreuse, A., King, H.M., Kurdziel, L.B., Partan, S.R., Caldwell, K.M., Chiavetta, M.R., Millette, M.M., Meyer, J.S. & Grow, D.R. (2010) Testosterone may increase attention to social threat in male rhesus monkeys. Hormones and Behavior, 58, 864-863.
King H.M., Kurdziel, L.B, Meyer, J.S. & Lacreuse, A. (2012). Effects of testosterone on attention and memory for emotional stimuli in male rhesus monkeys. Psychoneuroendocrinology, 37, 396-409.
Lacreuse, A., Schatz, K., Strazzullo, S., King, H.M. & Ready, R. (2013). Attentional biases and memory for emotional stimuli in men and male rhesus monkeys. Animal Cognition, 16, 861-871.
Kelly B., Maguire-Herring, V., Rose, C., Gore, H.E., Ferrigno, S., Novak, M.A. & Lacreuse, A. (2014). Short-term testosterone manipulations do not affect cognition or motor function but differentially modulate emotions in young and older male rhesus monkeys. Hormones and Behavior, 66, 731-742.
Lacreuse, A., Mong, J.A. and Hara, Y. (2015). Neurocognitive effects of estrogens across the adult lifespan in nonhuman primates: state of knowledge and new perspectives. Hormones and Behavior (invited review), 74, 157-166.
Kelly B, Maguire-Herring V, Rose CM, Gore HE, Ferrigno S, Novak MA, Lacreuse A (2014) Short-term testosterone manipulations do not affect cognition or motor function but differentially modulate emotions in young and older male rhesus monkeys Horm Behav 66:731-742.
Lacreuse, A., Mong, J.A., and Hara, Y. (2015) Neurocognitive effects of estrogens across the adult lifespan in nonhuman primates: State of knowledge and new perspectives. Hormones and Behavior, 74,157-66.
LaClair, M.G. and Lacreuse, A. (2016). Reversal learning in gonadectomized marmosets with and without hormone replacement: Are males more sensitive to punishment? Animal Cognition, 19, 619-630.
Gervais NJ, Viechweg SS, Mong JA, Lacreuse A (2016) The middle-aged ovariectomized marmoset (Callithrix jacchus) as a model of menopausal symptoms: Preliminary evidence Neuroscience 337:1-8.
 
Contact Info

Department of Psychological and Brain Sciences
Tobin Hall 531
135 Hicks Way
Amherst, MA 01003

(413) 545-2183
alacreuse@psych.umass.edu