Sex steroid hormones have widespread effects on brain structure and function, and affect behavior, mood and cognition. The main objective of our research is to understand the consequences of declining sex hormones, in particular estradiol and testosterone, for neurocognitive functioning in aging males and females. Specifically, our studies seek to determine whether the loss of sex hormones that occurs during aging exacerbates cognitive impairment and whether hormonal replacement therapy is an efficient intervention against age-related cognitive decline. We use primate models of human aging to address these questions.
Two main projects are currently taking place in the lab. A longitudinal study seeks to identify the biological correlates of sex differences in cognitive and brain aging, using behavioral, physiological and neuroimaging (fMRI) techniques. A second project aims to understand the relationships between estrogen loss, sleep disturbances and cognitive impairment in a primate model of menopause.
- PhD Université Paul Sabatier, Toulouse, France,1994
- Postdoctoral Training: University of Georgia, 1995; Emory University, 1997
- Postdoctoral Training: Yerkes Natl Primate Res Ctr, Emory University, 1997-2002
- Res Assistant Professor, Yerkes Natl Primate Res Ctr, Emory University 2002-2006
- Assistant Professor, University of Massachusetts, 2006-2012
- Associate Professor, University of Massachusetts, 2012-present