
Department of Veterinary and Animal Sciences
427F Integrated Sciences Building
660 North Pleasant Street
Amherst, MA 01003
(413) 545-4882
osborne@vasci.umass.edu
www.umass.edu/veterinary-animal-sciences/about/directory/barbara-osborne
Professor Emeritus of Veterinary and Animal Sciences
My laboratory focuses on the differentiation and function of mature CD4+ lymphocytes. In particular, we are interested in the role of Notch proteins in CD4+ maturation and function.
Current Research
Over the past several years, we have demonstrated that Notch plays a critical role in the differentiation of the T-helper 1 (Th1) and T-helper17 (Th17) subsets of T cells. Both Th1 and Th17 cells have been implicated in several diseases including experimental autoimmune encephalomyelitis (EAE), a mouse model of Multiple Sclerosis. Using gamma-secretase inhibitors (GSIs), compounds that block the activation of Notch, we have found that we can block the development of EAE in mice, suggesting that GSIs may be a possible therapeutic for the treatment of MS. Our current studies are focused on determining how Notch signaling influences the development of EAE as well as determining which Notch family member is important in the development of disease. In mammals, there are four Notch family members and it is unclear which Notch family member is most important in driving EAE. Additionally, in collaboration with our colleagues in the Center for Bioactive Delivery, we are actively engaged in developing tools that will allow us to selectively inhibit Notch signaling in potentially pathogenic T cells.
Academic Background
BA, English, Moravian College, 1970
PhD, Genetic & Immunology, Stanford University Medical School, 1979
Damon Runyon Postdoctoral fellow, National Institutes of Health, 1979-83