Manning College of Information & Computer Sciences
348 Computer Science Building
140 Governors Drive
Amherst, MA 01003-9292
(413) 577-0354
[email protected]
www.cics.umass.edu/about/directory/anna-green
Sequence Analysis and Genomics (SAGE) lab
Assistant Professor of Information & Computer Science
Our group aims to understand the genetic basis of antibiotic resistance in bacteria, with a particular emphasis on newly evolving mechanisms of resistance. Using machine learning applied to genomic sequences, combined with a deep understanding of molecular biology and bacterial genomics, we aim to build models that can both accurately predict antibiotic resistance from genome sequences, and also provide interpretable outputs about the genetic basis of resistance. Our long-term goal is for these models to detect newly evolved resistance, and even predict the potential of certain pathogens to evolve resistance. We are also striving to convert our understanding of resistance genomics into an ability to discover new antibiotics that will target essential cellular processes.
Current Research
Research focuses on three areas: (1) using the three-dimensional structure of proteins to contextualize mutations detected in genome sequence data, (2) analyzing huge dataset of bacterial genomes to detect new resistance genes, and (3) discovering new drugs to treat Mycobacterium tuberculosis via machine learning.
Learn more at Sequence Analysis and Genomics (SAGE) lab
Academic Background
- Postdoctoral Fellow, Biomedical Informatics, Harvard Medical School, 2019 - 2023
- PhD, Systems Biology, Harvard University, 2019
- BS, Molecular and Cell Biology, University of Connecticut, 2013