The Plant Cell Culture Library

Withania somnifera
Cell Line ID WS1967-T4-G5
Media Type B5
Availability Low
Order Solanales
Family Solanaceae
Genus Withania
Antiviral Species Level ➡ 2 citations
Antibacterial Species Level ➡ 15 citations
Antifungal Species Level ➡ 4 citations
Insecticidal Species Level
Anticancer Species Level ➡ 27 citations
Culture Start Material Greiner
Antiviral Citations
  1. Jain J, Narayanan V, Chaturvedi S, Pai S, Sunil S. In Vivo Evaluation of Withania somnifera-Based Indian Traditional Formulation ( Amukkara Choornam), Against Chikungunya Virus-Induced Morbidity and Arthralgia. J Evid Based Integr Med. 2018 Jan-Dec;23:2156587218757661. [https://doi.org/10.1177/2156587218757661.] PubMed PMID: 29484895; PubMed Central PMCID: PMC5871050.
  2. Cai Z, Zhang G, Tang B, Liu Y, Fu X, Zhang X. Promising Anti-influenza Properties of Active Constituent of Withania somnifera Ayurvedic Herb in Targeting Neuraminidase of H1N1 Influenza: Computational Study. Cell Biochem Biophys. 2015 Jul;72(3):727-39. [https://doi.org/10.1007/s12013-015-0524-9.] PubMed PMID: 25627548.
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Antibacterial Citations
  1. Marslin G, Selvakesavan RK, Franklin G, Sarmento B, Dias AC. Antimicrobial activity of cream incorporated with silver nanoparticles biosynthesized from Withania somnifera. Int J Nanomedicine. 2015 Sep 22;10:5955-63. [https://doi.org/10.2147/IJN.S81271.] eCollection 2015. PubMed PMID: 26445537; PubMed Central PMCID: PMC4590548.
  2. Kumari M, Gupta RP. In vitro antibacterial effect of Withania somnifera root extract on Escherichia coli. Vet World. 2015 Jan;8(1):57-60. [https://doi.org/10.14202/vetworld.2015.57-60.] Epub 2015 Jan 17. PubMed PMID: 27046997; PubMed Central PMCID: PMC4777812.
  3. Bisht P, Rawat V. Antibacterial activity of Withania somnifera against Gram-positive isolates from pus samples. Ayu. 2014 Jul-Sep;35(3):330-2. [https://doi.org/10.4103/0974-8520.153757.] PubMed PMID: 25972723; PubMed Central PMCID: PMC4427836.
  4. Mwitari PG, Ayeka PA, Ondicho J, Matu EN, Bii CC. Antimicrobial activity and probable mechanisms of action of medicinal plants of Kenya: Withania somnifera, Warbugia ugandensis, Prunus africana and Plectrunthus barbatus. PLoS One. 2013 Jun 13;8(6):e65619. [https://doi.org/10.1371/journal.pone.0065619.] Print 2013. PubMed PMID: 23785437; PubMed Central PMCID: PMC3681961.
  5. El-Boshy Mel-S, Abdalla OM, Risha A, Moustafa F. Effect of Withania somnifera Extracts on Some Selective Biochemical, Hematological, and Immunological Parameters in Guinea Pigs Experimental Infected with E. coli. ISRN Vet Sci. 2013 Mar 31;2013:153427. [https://doi.org/10.1155/2013/153427.] Print 2013. PubMed PMID: 23738137; PubMed Central PMCID: PMC3658418.
  6. Alam N, Hossain M, Mottalib MA, Sulaiman SA, Gan SH, Khalil MI. Methanolic extracts of Withania somnifera leaves, fruits and roots possess antioxidant properties and antibacterial activities. BMC Complement Altern Med. 2012 Oct 7;12:175. [https://doi.org/10.1186/1472-6882-12-175.] PubMed PMID: 23039061; PubMed Central PMCID: PMC3527235.
  7. Datta S, Kumar Pal NK, Nandy AK. Inhibition of the emergence of multi drug resistant Staphylococcus aureus by Withania somnifera root extracts. Asian Pac J Trop Med. 2011 Nov;4(11):917-20. [https://doi.org/10.1016/S1995-7645(11)60218-6.] PubMed PMID: 22078956.
  8. Singh G, Kumar P. Evaluation of antimicrobial efficacy of flavonoids of withania somnifera L. Indian J Pharm Sci. 2011 Jul;73(4):473-8. [https://doi.org/10.4103/0250-474X.95656.] PubMed PMID: 22707839; PubMed Central PMCID: PMC3374571.
  9. Kulkarni AA, Kelkar SM, Watve MG, Krishnamurthy KV. Characterization and control of endophytic bacterial contaminants in in vitro cultures of Piper spp., Taxus baccata subsp. wallichiana, and Withania somnifera. Can J Microbiol. 2007 Jan;53(1):63-74. PubMed PMID: 17496951.
  10. Girish KS, Machiah KD, Ushanandini S, Harish Kumar K, Nagaraju S, Govindappa M, Vedavathi M, Kemparaju K. Antimicrobial properties of a non-toxic glycoprotein (WSG) from Withania somnifera (Ashwagandha). J Basic Microbiol. 2006;46(5):365-74. PubMed PMID: 17009292.
  11. Owais M, Sharad KS, Shehbaz A, Saleemuddin M. Antibacterial efficacy of Withania somnifera (ashwagandha) an indigenous medicinal plant against experimental murine salmonellosis. Phytomedicine. 2005 Mar;12(3):229-35. PubMed PMID: 15830846.
  12. Arora S, Dhillon S, Rani G, Nagpal A. The in vitro antibacterial/synergistic activities of Withania somnifera extracts. Fitoterapia. 2004 Jun;75(3-4):385-8. PubMed PMID: 15159002.
  13. Das JM, Kurup PA. Mechanism of antibacterial action of antibiotic isolated from leaves of Withania somnifera. I. Reaction between the antibiotic & glutathione. Indian J Biochem. 1964 Sep;1(3):157-8. PubMed PMID: 4243417.
  14. BEN-EFRAIM S, YARDEN A. Comments on the activity of some constitutents of Withania somnifera Dun. I. The antibacterial activity of five nitrogen-free substances isolated from the leaves. Antibiot Chemother (Northfield). 1962 Sep;12:576-82. PubMed PMID: 13867009.
  15. KURUP PA. The antibacterial principle of Withania somnifera. I. Isoation and antibacterial activity. Antibiot Chemother (Northfield). 1958 Oct;8(10):511-5. PubMed PMID: 24544974.
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Antifungal Citations
  1. Marslin G, Selvakesavan RK, Franklin G, Sarmento B, Dias AC. Antimicrobial activity of cream incorporated with silver nanoparticles biosynthesized from Withania somnifera. Int J Nanomedicine. 2015 Sep 22;10:5955-63. [https://doi.org/10.2147/IJN.S81271.] eCollection 2015. PubMed PMID: 26445537; PubMed Central PMCID: PMC4590548.
  2. Mwitari PG, Ayeka PA, Ondicho J, Matu EN, Bii CC. Antimicrobial activity and probable mechanisms of action of medicinal plants of Kenya: Withania somnifera, Warbugia ugandensis, Prunus africana and Plectrunthus barbatus. PLoS One. 2013 Jun 13;8(6):e65619. [https://doi.org/10.1371/journal.pone.0065619.] Print 2013. PubMed PMID: 23785437; PubMed Central PMCID: PMC3681961.
  3. Singh G, Kumar P. Evaluation of antimicrobial efficacy of flavonoids of withania somnifera L. Indian J Pharm Sci. 2011 Jul;73(4):473-8. [https://doi.org/10.4103/0250-474X.95656.] PubMed PMID: 22707839; PubMed Central PMCID: PMC3374571.
  4. Ghosh M. Purification of a lectin-like antifungal protein from the medicinal herb, Withania somnifera. Fitoterapia. 2009 Mar;80(2):91-5. [https://doi.org/10.1016/j.fitote.2008.10.004.] Epub 2008 Oct 20. PubMed PMID: 18977281. Girish KS, Machiah KD, Ushanandini S, Harish Kumar K, Nagaraju S, Govindappa M, Vedavathi M, Kemparaju K. Antimicrobial properties of a non-toxic glycoprotein (WSG) from Withania somnifera (Ashwagandha). J Basic Microbiol. 2006;46(5):365-74. PubMed PMID: 17009292.
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Anticancer Citations
  1. Lavie, D. et al., JCS, 1965, 7517- 7531 (Withaferin A)
  2. McPhail, A.T. et al., JCS(B), 1968, 962- 972 (Withaferin A, cryst struct)
  3. Kupchan, S.M. et al., JOC, 1969, 34, 3858- 3866 (Withaferin A, isol, struct) [https://doi.org/10.1021/jo01264a027]
  4. Kirson, I. et al., Tetrahedron, 1970, 26, 2209- 2219 (5,6-epoxide) [https://doi.org/10.1016/S0040-4020(01)92800-5]
  5. Lockley, W.J.S. et al., Phytochemistry, 1976, 15, 937- 939 (biosynth) [https://doi.org/10.1016/S0031-9422(00)84374-5]
  6. Pelletier, S.W. et al., Heterocycles, 1981, 15, 317- 320 (Viscosalactone A) [https://doi.org/10.3987/S-1981-01-0317]
  7. Gottlieb, H.E. et al., Org. Magn. Reson., 1981, 16, 20- 25 (cmr)
  8. Nittala, S.S. et al., Phytochemistry, 1981, 20, 2735- 2739 (Acnistus breviflorus constit) [https://doi.org/10.1016/0031-9422(81)85277-6]
  9. Hirayama, M. et al., Tet. Lett., 1982, 23, 4725- 4728 (synth) [https://doi.org/10.1016/S0040-4039(00)85697-X]
  10. Valeiro, A.S. et al., Phytochemistry, 1985, 24, 2263- 2265, 2573 - 2575 (biosynth) [https://doi.org/10.1016/S0031-9422(00)83022-8]
  11. Monteagudo, E.S. et al., Z. Naturforsch., B, 1987, 42, 1471 (biosynth) [https://doi.org/10.1515/znb-1987-1117]
  12. Ghosal, S. et al., Indian J. Nat. Prod., 1988, 4, 12 (Sitoindosides)
  13. Sudhir, S. et al., Indian J. Physiol. Pharmacol., 1992, 36, 127 (pharmacol)
  14. Monteagudo, E.S. et al., Phytochemistry, 1994, 35, 927- 929 (biosynth) [https://doi.org/10.1016/S0031-9422(00)90640-X]
  15. Llanos, G.G. et al., Steroids, 2010, 75, 974- 981 (Withania aristata constit) [https://doi.org/10.1016/j.steroids.2010.06.001]
  16. Zhang, H. et al., J. Nat. Prod., 2011, 74, 2532- 2544; 2012, 75, 306§ (Withalongolide H) [https://doi.org/10.1021/np200635r]
  17. Xu, Y.-M. et al., Phytochemistry, 2011, 72, 518- 522 (3-Uracilyl-2,3-dihydrowithaferin A, 3-Adeninyl-2,3-dihydrowithaferin A)
  18. Llamos, G.G. et al., Eur. J. Med. Chem., 2012, 54, 499- 511 (Withania aristata esters) [https://doi.org/10.1016/j.ejmech.2012.05.032]
  19. Bolleddula, J. et al., Rapid Commun. Mass Spectrom., 2012, 26, 1277- 1290 (5,6-Epoxy-4,27-dihydroxy-1-oxowith-2-enolide)
  20. Glotter, E. et al., Tetrahedron, 1973, 29, 1353- 1364 (Withanolide J) [https://doi.org/10.1016/S0040-4020(01)83156-2]
  21. Glotter, E. et al., JCS Perkin 1, 1977, 341- 346 (Withanolides E,F) [https://doi.org/10.1039/P19770000341]
  22. Hunter, I.R. et al., J. Chromatogr., 1979, 170, 437- 442 (hplc) [https://doi.org/10.1016/S0021-9673(00)95472-4]
  23. Kirson, I. et al., J. Chem. Res., Synop., 1980, 338- 339; J. Chem. Res., Miniprint, 1980, 4275 - 4293 (17-Isowithanolide E)
  24. Gottlieb, H.E. et al., Org. Magn. Reson., 1981, 16, 20- 25 (cmr)
  25. Neogi, P. et al., Phytochemistry, 1987, 26, 243- 247 (Withaperuvin G) [https://doi.org/10.1016/S0031-9422(00)81520-4]
  26. Dinan, L.N. et al., Phytochemistry, 1997, 44, 509- 512 (28-Hydroxywithanolide E) [https://doi.org/10.1016/S0031-9422(96)00553-5]
  27. Fang, S.-T. et al., Steroids, 2012, 77, 36- 44 (Withaperuvin J) [https://doi.org/10.1016/j.steroids.2011.09.011]
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Inquiries regarding the purchase of Plant cell lines or other PCCL services can be directed to Michael Daley mpdaley@umass.edu

Acknowledgements

The establishment of the PCCL has been sponsored by National Science Foundation (NSF/DBI-156 1572), United States Department of Agriculture Massachusetts Experiment Station Award (MAS00496), the Science and Technology fund from the President's office of the University of Massachusetts, and the 2016 UMass Amherst Armstrong Fund for Science.

National Science FoundationCenter for Agriculture, Food and the Environment

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