The Plant Cell Culture Library

Tripterygium wilfordii
Cell Line ID TW-00881-L3
Media Type B90
Lowest Tolerable USDA Zone 8b
Drought Tolerance Averag
Availability Low
Order Celastrales
Family Celastraceae
Genus Tripterygium
Antiviral Species Level ➡ 5 citations
Anticancer Species Level ➡ 34 citations
Culture Start Material Suspension Callus
Antiviral Citations
  1. Li T, Xie J, Li Y, Routy JP, Li Y, Han Y, Qiu Z, Lv W, Song X, Sun M, Zhang X, Wang F, Jiang H. Tripterygium wilfordii Hook F extract in cART-treated HIV patients with poor immune response: a pilot study to assess its immunomodulatory effects and safety. HIV Clin Trials. 2015 Mar-Apr;16(2):49-56. [https://doi.org/10.1179/1528433614Z.0000000005.] Epub 2015 Jan 26. PubMed PMID: 25874991.
  2. Duan H, Takaishi Y, Imakura Y, Jia Y, Li D, Cosentino LM, Lee KH. Sesquiterpene alkaloids from Tripterygium hypoglaucum and Tripterygium wilfordii: a new class of potent anti-HIV agents. J Nat Prod. 2000 Mar;63(3):357-61. PubMed PMID: 10757718.
  3. Chen K, Shi Q, Fujioka T, Nakano T, Hu CQ, Jin JQ, Kilkuskie RE, Lee KH. Anti-AIDS agents--XIX. Neotripterifordin, a novel anti-HIV principle from Tripterygium wilfordii: isolation and structural elucidation. Bioorg Med Chem. 1995 Oct;3(10):1345-8. PubMed PMID: 8564400.
  4. Chen K, Shi Q, Kashiwada Y, Zhang DC, Hu CQ, Jin JQ, Nozaki H, Kilkuskie RE, Tramontano E, Cheng YC, et al. Anti-aids agents, 6. Salaspermic acid, an anti-HIV principle from Tripterygium wilfordii, and the structure-activity correlation with its related compounds. J Nat Prod. 1992 Mar;55(3):340-6. PubMed PMID: 1375626.
  5. Chen K, Shi QA, Fujioka T, Zhang DC, Hu CQ, Jin JQ, Kilkuskie RE, Lee KH. Anti-AIDS agents, 4. Tripterifordin, a novel anti-HIV principle from Tripterygium wilfordii: isolation and structural elucidation. J Nat Prod. 1992 Jan;55(1):88-92. PubMed PMID: 1602302.
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Anticancer Citations
  1. Kupchan, S.M. et al., JACS, 1972, 94, 7194- 7195 (Triptolide, Tripdiolide, cryst struct) [https://doi.org/10.1021/ja00775a078]
  2. Gilmore, C.J. et al., JCS Perkin 2, 1973, 816- 819 (Triptolide, Tripdiolide, cryst struct) [https://doi.org/10.1039/p29730000816]
  3. Kupchan, S.M. et al., Science (Washington, D.C.), 1974, 185, 791- 793 (Tripterygium wilfordii constits, activity, rev) [https://doi.org/10.1126/science.185.4153.791]
  4. Wu, D.-G. et al., Yunnan Zhiwu Yanjiu, 1979, 1, 29- 36 (Tripterolide)
  5. Kutney, J.P. et al., Can. J. Chem., 1981, 59, 2677- 2683 (Tripdiolide) [https://doi.org/10.1139/v81-385]
  6. Garver, L.C. et al., JACS, 1982, 104, 867- 869 ((±)-Triptolide, (±)-Tripdiolide, synth) [https://doi.org/10.1021/ja00367a046]
  7. Van Tamelen, E.E. et al., JACS, 1982, 104, 1785- 1786 ((±)-Triptolide, (±)-Tripdiolide, synth) [https://doi.org/10.1021/ja00370a077]
  8. Lai, C.K. et al., JOC, 1982, 47, 2364- 2369 ((±)-Triptolide, (±)-Tripdiolide, synth) [https://doi.org/10.1021/jo00133a026]
  9. Ma, P.C. et al., Yaoxue Xuebao, 1991, 26, 759- 763 (Tripterygin)
  10. Ma, P. et al., Zhiwu Xuebao, 1991, 33, 370- 377 (Triptriolide)
  11. Deng, F. et al., Zhiwu Xuebao, 1992, 34, 618- 621 (Triptetraolide)
  12. Zhang, C. et al., Yaoxue Xuebao, 1993, 28, 110- 115 (Tripdioltonide)
  13. Lin, S. et al., Yaoxue Xuebao, 1993, 35, 385- 389 (Isotriptetraolide)
  14. Ma, P. et al., Zhiwu Xuebao, 1993, 35, 637- 643 (Epitriptriolide)
  15. Pat. Coop. Treaty (WIPO), 1995, 95 15 174 (Tripterygin)
  16. Kutney, J.P. et al., Recl. Trav. Chim. (J. R. Neth. Chem. Soc.), 1996, 115, 77- 93 (Tripterygium wilfordii constits, biosynth)
  17. Ma, P.C. et al., Zhiwu Xuebao, 1996, 38, 234- 240 (Dichlorotriptetraolide)
  18. US Pat., 1997, 5 663 335, ( Pharmagenesis) (PG 490-88, synth)
  19. Yang, D. et al., JOC, 1998, 63, 6446- 6447 (synth) [https://doi.org/10.1021/jo981362g]
  20. Yang, D. et al., JOC, 2000, 65, 2208- 2217 (synth) [https://doi.org/10.1021/jo9919613]
  21. Wang, J. et al., Transplantation, 2000, 70, 447- 455 (PG 490-88, pharmacol) [https://doi.org/10.1097/00007890-200008150-00010]
  22. Krishna, G. et al., Am. J. Pathol., 2001, 158, 997- 1004 (PG 490-88, pharmacol) [https://doi.org/10.1016/S0002-9440(10)64046-1]
  23. Chen, B.J. et al., Drugs of the Future, 2002, 27, 57- 63 (PG 490-88, rev) [https://doi.org/10.1358/dof.2002.027.01.647608]
  24. Fidler, J.M. et al., Mol. Cancer Ther., 2003, 2, 855- 862 (PG 490-88, pharmacol)
  25. Wang, X. et al., Transplantation, 2005, 79, 1537- 1544 (PG 490-88, pharmacol) [https://doi.org/10.1097/01.TP.0000159149.07292.2B]
  26. Chen, G. et al., Am. J. Transplant., 2006, 6, 714- 723 (PG 490-88, pharmacol)
  27. Goncalves, S. et al., Chem. Comm., 2010, 46, 5778- 5780 (synth) [https://doi.org/10.1039/c0cc00250j]
  28. Zhou, B. et al., Tetrahedron, 2010, 66, 5396- 5401 (Triptolide, synth) [https://doi.org/10.1016/j.tet.2010.05.035]
  29. Zhou, B. et al., Tetrahedron, 2011, 67, 904- 909 (synth) [https://doi.org/10.1016/j.tet.2010.12.014]
  30. Xu, H. et al., JOC, 2014, 79, 10110- 10122 (synth) [https://doi.org/10.1021/jo501744j]
  31. Zhang, H. et al., Org. Biomol. Chem., 2014, 12, 732- 736 (synth)
  32. Chen, Y. et al., Nat. Prod. Bioprospect., 2016, 6, 183- 186 (synth)
  33. Cannillo, A. et al., Org. Lett., 2016, 18, 2592- 2595 (synth) [https://doi.org/10.1021/acs.orglett.6b00968]
  34. Sax's Dangerous Properties of Industrial Materials, 11th edn., J. Wiley, 2004, TNC175
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