The Plant Cell Culture Library

Euphorbia neococcinea
Cell Line ID MC-07071
Media Type B113
Availability High
Order Malpighiales
Family Euphorbiaceae
Genus Euphorbia
Antiviral Genus Level ➡ 50 citations
Antibacterial Genus Level ➡ 51 citations
Antifungal Genus Level ➡ 110 citations
Trypanocidal Genus Level ➡ 15 citations
Anthelmintic Genus Level ➡ 6 citations
Insecticidal Genus Level ➡ 9 citations
Anticancer Genus Level
Culture Initiation Site Copenhagen Botanical Garden Lab
Plant Habit Herb Perennial
Plant Habitat SubTrop/Trop
Culture Start Material Shoot
Native Range Tanzania
Plant Supplier Botanical Garden Copenhagen
Antiviral Citations
  1. Chumbalov, T.K. et al., Chem. Nat. Compd. (Engl. Transl.), 1970, 6, 523- 524 (Collinin)
  2. Seikel, M.K. et al., Phytochemistry, 1970, 9, 1115- 1128 (Eucalyptus delegatensis constit) [https://doi.org/10.1016/S0031-9422(00)85235-8]
  3. Wilkins, C.K. et al., Phytochemistry, 1976, 15, 211- 214 (Tellimagrandins) [https://doi.org/10.1016/S0031-9422(00)89087-1]
  4. Rao, K.V., Lloydia, 1977, 40, 169- 172 (Hippomanin A)
  5. Nonaka, G.I. et al., Chem. Pharm. Bull., 1980, 28, 685- 687 (Eugeniin, isol, struct) [https://doi.org/10.1248/cpb.28.685]
  6. Okuda, T. et al., Chem. Pharm. Bull., 1982, 30, 766- 768 (Strictinin) [https://doi.org/10.1248/cpb.30.766]
  7. Yoshida, T., Chem. Pharm. Bull., 1982, 30, 4245- 4248 (Gemin D) [https://doi.org/10.1248/cpb.30.4245]
  8. Gupta, R.K. et al., JCS Perkin 1, 1982, 2525- 2534 (Tellimagrandins, occur, pmr, cmr) [https://doi.org/10.1039/p19820002525]
  9. Okuda, T. et al., JCS Perkin 1, 1983, 1765- 1772 (Strictinin) [https://doi.org/10.1039/p19830001765]
  10. Nonaka, G. et al., Phytochemistry, 1984, 23, 1753- 1755 (pmr) [https://doi.org/10.1016/S0031-9422(00)83484-6]
  11. Yoshida, T. et al., Phytochemistry, 1985, 24, 1401- 1406 (Gemin D) [https://doi.org/10.1016/S0031-9422(00)83179-9]
  12. Lee, S.-H. et al., Phytochemistry, 1989, 28, 3469- 3472; 1990, 29, 3621 - 3625 (Hippomanin A, Eugeniin, struct, pmr) [https://doi.org/10.1016/0031-9422(89)80366-8]
  13. Yoshida, T. et al., Chem. Pharm. Bull., 1991, 39, 49- 54, 2849 - 2854 (Heterophylliin A, β-D-isomer) [https://doi.org/10.1248/cpb.39.49]
  14. El-Mousallamy, A.M.D. et al., Phytochemistry, 1991, 30, 3767- 3768 (Acacia raddiana constit) [https://doi.org/10.1016/0031-9422(91)80106-B]
  15. Nakashima, H. et al., Antiviral Res., 1992, 18, 91- 103 (activity, rev) [https://doi.org/10.1016/0166-3542(92)90008-S]
  16. Feldman, K.S. et al., JACS, 1994, 116, 1742- 1745 (synth, Tellimagrandin I) [https://doi.org/10.1021/ja00084a015]
  17. Nelson, T.D. et al., JOC, 1994, 59, 2577- 2580 (synth, Tellimagrandins) [https://doi.org/10.1021/jo00088a046]
  18. Khanbabaee, K. et al., Tet. Lett., 1997, 38, 1367- 1368 (synth, Strictinin) [https://doi.org/10.1016/S0040-4039(97)00033-6]
  19. Lee, S.-H. et al., Yakhak Hoechi, 1997, 41, 524- 529 (activity)
  20. Khanbabaee, K. et al., J. Prakt. Chem., 1999, 341, 159- 166 (Hippomanin A, Gemin D,synth, ir, uv, pmr, cmr)
  21. Feldman, K.S. et al., JOC, 1999, 64, 209- 216 (synth, Tellimagrandin II) [https://doi.org/10.1021/jo9816966]
  22. Itoh, A. et al., J. Nat. Prod., 2000, 63, 95- 98 (isol, 2-(hydroxymethyl)phenyl glycosides) [https://doi.org/10.1021/np990391z]
  23. Jiang, Z.-H. et al., Chem. Pharm. Bull., 2001, 49, 887- 892 (Balanophora japonica tannins) [https://doi.org/10.1248/cpb.49.887]
  24. Khanbabaee, K. et al., Tetrahedron, 2002, 58, 1159- 1163 (1,3-DigalloylHHDP-β-D-glucose,synth, pmr, cmr) [https://doi.org/10.1016/S0040-4020(01)01210-8]
  25. Bokesch, H.R. et al., J. Nat. Prod., 2008, 71, 1634- 1636 (Hyemaloside C) [https://doi.org/10.1021/np8002518]
  26. Yagi, K. et al., Chem. Pharm. Bull., 2009, 57, 1284- 1288 (1,2-DigalloylHHDP-β-D-glucose) [https://doi.org/10.1248/cpb.57.1284]
  27. Panthama, N. et al., Chem. Pharm. Bull., 2009, 57, 1352- 1355 (1-Cinnamoyl-3-galloyl HHDP glucoses) [https://doi.org/10.1248/cpb.57.1352]
  28. Tamura, S., Bioorg. Med. Chem. Lett., 2010, 20, 1598- 1600 (Tellimagrandin I, activity) [https://doi.org/10.1016/j.bmcl.2010.01.084]
  29. Bao, L.-M. et al., Heterocycles, 2012, 85, 365- 381 (Tellimagrandin II, activity)
  30. Zheng, S. et al., Org. Biomol. Chem., 2012, 10, 2590- 2593 (synth)
  31. Michiharta, N. et al., JOC, 2013, 78, 4319- 4328 (Strictinin, synth) [https://doi.org/10.1021/jo4003135]
  32. Yoshida, T. et al., Chem. Pharm. Bull., 1990, 38, 3296- 3302 (struct) [https://doi.org/10.1248/cpb.38.3296]
  33. Namba, O. et al., Planta Med., 1990, 56, 587 (isol) [https://doi.org/10.1055/s-2006-961194]
  34. Kulkosky, J. et al., Blood, 2001, 98, 3006- 3015 (pharmacol) [https://doi.org/10.1182/blood.V98.10.3006]
  35. Lin, J.-H. et al., Chem. Pharm. Bull., 1990, 38, 1844- 1851 (Macaranga sinensis constit) [https://doi.org/10.1248/cpb.38.1844]
  36. El-Mekkawy, S. et al., Chem. Pharm. Bull., 1995, 43, 641- 648 (Phyllanthus emblica constit,struct, activity) [https://doi.org/10.1248/cpb.43.641]
  37. Zhang, Y.L. et al., Biol. Pharm. Bull., 2004, 27, 251- 255 (pharmacol) [https://doi.org/10.1248/bpb.27.251]
  38. Cheng, H.Y. et al., J. Antimicrob. Chemother., 2004, 53, 577- 583 (herpes simplex activity) [https://doi.org/10.1093/jac/dkh136]
  39. Kuo, P.-L. et al., Toxicol. Appl. Pharmacol., 2006, 213, 37- 45 (anticancer activity) [https://doi.org/10.1016/j.taap.2005.08.003]
  40. Arigoni, D. et al., Helv. Chim. Acta, 1955, 38, 222 (isol)
  41. Barton, D.H.R. et al., JCS, 1956, 4150 (isol)
  42. Walters, B. et al., Planta Med., 1970, 19, 189- 193 (activity)
  43. Aiyar, V.N. et al., Curr. Sci., 1974, 43, 75 (Tirucallol acetate)
  44. Monaco, P. et al., Phytochemistry, 1974, 13, 1992 (Tirucallone)
  45. Caputo, R. et al., Phytochemistry, 1975, 14, 809 (Tirucallone)
  46. Boar, R.B. et al., J. Chem. Res., Synop., 1982, 94 (synth)
  47. Nes, W.D. et al., Proc. Natl. Acad. Sci. U.S.A., 1984, 81, 5896 (cryst struct)
  48. Bartlett, W.R. et al., JOC, 1990, 55, 2215 (synth)
  49. Akihisa, T. et al., J. Nat. Prod., 1998, 61, 409- 412 (pmr, cmr)
  50. Zheng, W.F. et al., Planta Med., 1998, 64, 754- 756 (isol, activity)
[top⬆]
Antibacterial Citations
  1. Xu, Z.-H. et al., Phytochemistry, 1998, 49, 149- 151 (Yuexiandajisu A, cryst struct, activity) [https://doi.org/10.1016/S0031-9422(97)00900-X]
  2. Kong, L.-Y. et al., Planta Med., 2002, 68, 249- 252 (Euphpekinensin, Euphorhylonal A) [https://doi.org/10.1055/s-2002-23132]
  3. Liang, Q.-L. et al., Fitoterapia, 2009, 80, 514- 516 (Pekinenal, cryst struct) [https://doi.org/10.1016/j.fitote.2009.06.014]
  4. Shao, F.-G. et al., J. Asian Nat. Prod. Res., 2011, 13, 805- 810 (Pekinenins A,B)
  5. Tao, W.W. et al., Phytochemistry, 2013, 94, 249- 253 (Pekinenins C,D,E) [https://doi.org/10.1016/j.phytochem.2013.06.009]
  6. Alder, K. et al., Annalen, 1959, 620, 73- 87 (synth)
  7. Hart, N.K. et al., Aust. J. Chem., 1967, 20, 561- 563 (isol, ir, pmr, ms) [https://doi.org/10.1071/CH9670561]
  8. Brown, W.V. et al., Aust. J. Chem., 1982, 35, 1255- 1261 (isol) [https://doi.org/10.1071/CH9821255]
  9. Hill, R.K. et al., Tetrahedron, 1982, 38, 1958- 1963 (synth)
  10. Gnecco Medina, D.H. et al., Tet. Lett., 1983, 24, 2099- 2102 (synth) [https://doi.org/10.1016/S0040-4039(00)81854-7]
  11. Eisner, T. et al., Experientia, 1986, 42, 204- 207 (isol)
  12. Yue, C. et al., JOC, 1992, 57, 4211- 4214 (synth, abs config) [https://doi.org/10.1021/jo00041a028]
  13. Tawara, J.N. et al., JOC, 1993, 58, 4813- 4818 (activity) [https://doi.org/10.1021/jo00070a014]
  14. Davison, E.C. et al., Tet. Lett., 1995, 36, 9047- 9050 (synth) [https://doi.org/10.1016/0040-4039(95)01908-Z]
  15. Tawara, J.N. et al., J. Nat. Prod., 1999, 62, 321- 323 (N-Methyleuphococcinine) [https://doi.org/10.1021/np9802769]
  16. Murahashi, S. et al., Heterocycles, 2000, 52, 557- 561 (synth) [https://doi.org/10.3987/COM-99-S81]
  17. Mechelke, M.F. et al., Tet. Lett., 2000, 41, 4339- 4342 (synth) [https://doi.org/10.1016/S0040-4039(00)00665-1]
  18. Arbour, M. et al., JOC, 2009, 74, 3806- 3814 (synth) [https://doi.org/10.1021/jo9001992]
  19. Davis, F.A. et al., Org. Lett., 2010, 12, 848- 851, s1 - s7 (synth) [https://doi.org/10.1021/ol902910w]
  20. Curd, F.H. et al., JCS, 1933, 437- 444 (synth)
  21. Baldwin, M.E. et al., Tetrahedron, 1961, 16, 206- 211 (4,6-di-Me ether) [https://doi.org/10.1016/0040-4020(61)80072-0]
  22. Huneck, S., Phytochemistry, 1972, 11, 3311 (Bancroftinone) [https://doi.org/10.1016/S0031-9422(00)86396-7]
  23. Bolognese, A. et al., Phytochemistry, 1974, 13, 1989 (2'-Me ether, isol) [https://doi.org/10.1016/0031-9422(74)85131-9]
  24. Cann, M.R. et al., Chem. Ind. (London), 1982, 779 (pmr)
  25. Lojanapiwatna, V. et al., J. Sci. Soc. Thailand, 1982, 8, 95 (6'-Me ether) [https://doi.org/10.2306/scienceasia1513-1874.1982.08.095]
  26. Linde, H. et al., Arch. Pharm. (Weinheim, Ger.), 1983, 316, 917 (4',6'-di-Me ether, isol)
  27. Hylands, P.J. et al., Phytochemistry, 1985, 24, 127- 129 (pmr, cmr, struct) [https://doi.org/10.1016/S0031-9422(00)80821-3]
  28. Kouno, I. et al., Phytochemistry, 1985, 24, 620- 621 (4'-Me ether) [https://doi.org/10.1016/S0031-9422(00)80788-8]
  29. Zhang, H. et al., CA, 1993, 118, 35926 (6'-Me ether)
  30. Brophy, J.J. et al., J. Essent. Oil Res., 1995, 7, 237 (Bancroftinone)
  31. Youssef, D.T.A. et al., Phytochemistry, 1998, 49, 2579- 2583 (6'-Me ether) [https://doi.org/10.1016/S0031-9422(98)00429-4]
  32. Wang, W. et al., Yaoxue Xuebao, 1999, 34, 514- 517 (Ebractelatinoside C)
  33. Sawada, S. et al., Bull. Kyoto Univ. Educ., Ser. B, 2000, 95/96, 1- 9 (Methylxanthoxylin,activity)
  34. Yin, Z.-Q. et al., Planta Med., 2005, 71, 979- 982 (6'-Me 4'-arabinosylglucoside) [https://doi.org/10.1055/s-2005-871301]
  35. Al-Sayed, E. et al., Nat. Prod. Commun., 2010, 5, 1639- 1642 (6'-glucoside)
  36. Curd, F.H. et al., JCS, 1933, 437- 444 (synth)
  37. Baldwin, M.E. et al., Tetrahedron, 1961, 16, 206- 211 (4,6-di-Me ether) [https://doi.org/10.1016/0040-4020(61)80072-0]
  38. Huneck, S., Phytochemistry, 1972, 11, 3311 (Bancroftinone) [https://doi.org/10.1016/S0031-9422(00)86396-7]
  39. Bolognese, A. et al., Phytochemistry, 1974, 13, 1989 (2'-Me ether, isol) [https://doi.org/10.1016/0031-9422(74)85131-9]
  40. Cann, M.R. et al., Chem. Ind. (London), 1982, 779 (pmr)
  41. Lojanapiwatna, V. et al., J. Sci. Soc. Thailand, 1982, 8, 95 (6'-Me ether) [https://doi.org/10.2306/scienceasia1513-1874.1982.08.095]
  42. Linde, H. et al., Arch. Pharm. (Weinheim, Ger.), 1983, 316, 917 (4',6'-di-Me ether, isol)
  43. Hylands, P.J. et al., Phytochemistry, 1985, 24, 127- 129 (pmr, cmr, struct) [https://doi.org/10.1016/S0031-9422(00)80821-3]
  44. Kouno, I. et al., Phytochemistry, 1985, 24, 620- 621 (4'-Me ether) [https://doi.org/10.1016/S0031-9422(00)80788-8]
  45. Zhang, H. et al., CA, 1993, 118, 35926 (6'-Me ether)
  46. Brophy, J.J. et al., J. Essent. Oil Res., 1995, 7, 237 (Bancroftinone)
  47. Youssef, D.T.A. et al., Phytochemistry, 1998, 49, 2579- 2583 (6'-Me ether) [https://doi.org/10.1016/S0031-9422(98)00429-4]
  48. Wang, W. et al., Yaoxue Xuebao, 1999, 34, 514- 517 (Ebractelatinoside C)
  49. Sawada, S. et al., Bull. Kyoto Univ. Educ., Ser. B, 2000, 95/96, 1- 9 (Methylxanthoxylin,activity)
  50. Yin, Z.-Q. et al., Planta Med., 2005, 71, 979- 982 (6'-Me 4'-arabinosylglucoside) [https://doi.org/10.1055/s-2005-871301]
  51. Al-Sayed, E. et al., Nat. Prod. Commun., 2010, 5, 1639- 1642 (6'-glucoside)
[top⬆]
Antifungal Citations
  1. Chumbalov, T.K. et al., Chem. Nat. Compd. (Engl. Transl.), 1970, 6, 523- 524 (Collinin)
  2. Seikel, M.K. et al., Phytochemistry, 1970, 9, 1115- 1128 (Eucalyptus delegatensis constit) [https://doi.org/10.1016/S0031-9422(00)85235-8]
  3. Wilkins, C.K. et al., Phytochemistry, 1976, 15, 211- 214 (Tellimagrandins) [https://doi.org/10.1016/S0031-9422(00)89087-1]
  4. Rao, K.V., Lloydia, 1977, 40, 169- 172 (Hippomanin A)
  5. Nonaka, G.I. et al., Chem. Pharm. Bull., 1980, 28, 685- 687 (Eugeniin, isol, struct) [https://doi.org/10.1248/cpb.28.685]
  6. Okuda, T. et al., Chem. Pharm. Bull., 1982, 30, 766- 768 (Strictinin) [https://doi.org/10.1248/cpb.30.766]
  7. Yoshida, T., Chem. Pharm. Bull., 1982, 30, 4245- 4248 (Gemin D) [https://doi.org/10.1248/cpb.30.4245]
  8. Gupta, R.K. et al., JCS Perkin 1, 1982, 2525- 2534 (Tellimagrandins, occur, pmr, cmr) [https://doi.org/10.1039/p19820002525]
  9. Okuda, T. et al., JCS Perkin 1, 1983, 1765- 1772 (Strictinin) [https://doi.org/10.1039/p19830001765]
  10. Nonaka, G. et al., Phytochemistry, 1984, 23, 1753- 1755 (pmr) [https://doi.org/10.1016/S0031-9422(00)83484-6]
  11. Yoshida, T. et al., Phytochemistry, 1985, 24, 1401- 1406 (Gemin D) [https://doi.org/10.1016/S0031-9422(00)83179-9]
  12. Lee, S.-H. et al., Phytochemistry, 1989, 28, 3469- 3472; 1990, 29, 3621 - 3625 (Hippomanin A, Eugeniin, struct, pmr) [https://doi.org/10.1016/0031-9422(89)80366-8]
  13. Yoshida, T. et al., Chem. Pharm. Bull., 1991, 39, 49- 54, 2849 - 2854 (Heterophylliin A, β-D-isomer) [https://doi.org/10.1248/cpb.39.49]
  14. El-Mousallamy, A.M.D. et al., Phytochemistry, 1991, 30, 3767- 3768 (Acacia raddiana constit) [https://doi.org/10.1016/0031-9422(91)80106-B]
  15. Nakashima, H. et al., Antiviral Res., 1992, 18, 91- 103 (activity, rev) [https://doi.org/10.1016/0166-3542(92)90008-S]
  16. Feldman, K.S. et al., JACS, 1994, 116, 1742- 1745 (synth, Tellimagrandin I) [https://doi.org/10.1021/ja00084a015]
  17. Nelson, T.D. et al., JOC, 1994, 59, 2577- 2580 (synth, Tellimagrandins) [https://doi.org/10.1021/jo00088a046]
  18. Khanbabaee, K. et al., Tet. Lett., 1997, 38, 1367- 1368 (synth, Strictinin) [https://doi.org/10.1016/S0040-4039(97)00033-6]
  19. Lee, S.-H. et al., Yakhak Hoechi, 1997, 41, 524- 529 (activity)
  20. Khanbabaee, K. et al., J. Prakt. Chem., 1999, 341, 159- 166 (Hippomanin A, Gemin D,synth, ir, uv, pmr, cmr)
  21. Feldman, K.S. et al., JOC, 1999, 64, 209- 216 (synth, Tellimagrandin II) [https://doi.org/10.1021/jo9816966]
  22. Itoh, A. et al., J. Nat. Prod., 2000, 63, 95- 98 (isol, 2-(hydroxymethyl)phenyl glycosides) [https://doi.org/10.1021/np990391z]
  23. Jiang, Z.-H. et al., Chem. Pharm. Bull., 2001, 49, 887- 892 (Balanophora japonica tannins) [https://doi.org/10.1248/cpb.49.887]
  24. Khanbabaee, K. et al., Tetrahedron, 2002, 58, 1159- 1163 (1,3-DigalloylHHDP-β-D-glucose,synth, pmr, cmr) [https://doi.org/10.1016/S0040-4020(01)01210-8]
  25. Bokesch, H.R. et al., J. Nat. Prod., 2008, 71, 1634- 1636 (Hyemaloside C) [https://doi.org/10.1021/np8002518]
  26. Yagi, K. et al., Chem. Pharm. Bull., 2009, 57, 1284- 1288 (1,2-DigalloylHHDP-β-D-glucose) [https://doi.org/10.1248/cpb.57.1284]
  27. Panthama, N. et al., Chem. Pharm. Bull., 2009, 57, 1352- 1355 (1-Cinnamoyl-3-galloyl HHDP glucoses) [https://doi.org/10.1248/cpb.57.1352]
  28. Tamura, S., Bioorg. Med. Chem. Lett., 2010, 20, 1598- 1600 (Tellimagrandin I, activity) [https://doi.org/10.1016/j.bmcl.2010.01.084]
  29. Bao, L.-M. et al., Heterocycles, 2012, 85, 365- 381 (Tellimagrandin II, activity)
  30. Zheng, S. et al., Org. Biomol. Chem., 2012, 10, 2590- 2593 (synth)
  31. Michiharta, N. et al., JOC, 2013, 78, 4319- 4328 (Strictinin, synth) [https://doi.org/10.1021/jo4003135]
  32. Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 323A, 323C, 325B (ir)
  33. Aldrich Library of 13C and 1H FT-NMR Spectra, 1992, 2, 1312C, 1313C, 1315C (nmr)
  34. Sommer, C., Arch. Pharm. (Weinheim, Ger.), 1859, 148, 1- 17 (Ferula galbaniflora constit)
  35. Sethna, S. et al., Org. React. (N.Y.), 1953, 7, 20- 21 (synth)
  36. Sen, K. et al., JOC, 1959, 24, 316- 319 (synth, uv) [https://doi.org/10.1021/jo01085a008]
  37. Brown, S.A., Phytochemistry, 1963, 2, 137- 144 (4-Me ether, biosynth) [https://doi.org/10.1016/S0031-9422(00)82973-8]
  38. Barnes, C.J. et al., Aust. J. Chem., 1964, 17, 975- 986 (ms) [https://doi.org/10.1071/CH9640975]
  39. Kir'yalov, N.P. et al., CA, 1966, 64, 19094 (Gummosinin)
  40. Das Gupta, A.K. et al., JCS(C), 1969, 29- 33 (synth)
  41. Jurd, L. et al., Phytochemistry, 1971, 10, 2965- 2970 (Me ether, activity) [https://doi.org/10.1016/S0031-9422(00)97333-3]
  42. Lassak, E.V. et al., Aust. J. Chem., 1972, 25, 2491- 2496 (Euodia vitiflora constits) [https://doi.org/10.1071/CH9722491]
  43. Konstitution und Vorkommen der Organischen Pflanzenstoffe, 2nd edn., Birkhäuser Verlag, 1972, no. 1320
  44. González, A.G. et al., An. Quim., 1973, 69, 1013 (pmr)
  45. Kamilov, K.M. et al., Chem. Nat. Compd. (Engl. Transl.), 1973, 9, 294- 298 (Kopetin) [https://doi.org/10.1007/BF00565684]
  46. Huitnik, G.M. et al., Talanta, 1974, 21, 1193- 1202 (detn, Ca, Cu) [https://doi.org/10.1016/0039-9140(74)80102-5]
  47. Günther, H. et al., Org. Magn. Reson., 1975, 7, 339- 344 (cmr)
  48. Cussans, N.J. et al., Tetrahedron, 1975, 31, 2719- 2726 (cmr) [https://doi.org/10.1016/0040-4020(75)80338-3]
  49. Holzbecher, Z. et al., Handbook of Organic Reagents in Inorganic Analysis, Horwood, Chichester, 1976 (ind)
  50. Williams, M. et al., J. Pharm. Sci., 1976, 65, 912- 914 (Coronilla varia constit) [https://doi.org/10.1002/jps.2600650628]
  51. Murray, R.D.H., Fortschr. Chem. Org. Naturst., 1978, 35, 200- 429 (rev)
  52. Chatterjee, A. et al., Phytochemistry, 1980, 19, 2219- 2220 (phenylacetate) [https://doi.org/10.1016/S0031-9422(00)82233-5]
  53. Esterbauer, H. et al., Z. Naturforsch., C, 1980, 35, 682- 684 (isol)
  54. Hardt, T.J., Diss. Abstr. Int., B, 1982, 43, 1445 (pharmacol)
  55. Ritschel, W.A. et al., Arzneim.-Forsch., 1983, 33, 836 (metab)
  56. Batsurén, D. et al., Chem. Nat. Compd. (Engl. Transl.), 1983, 19, 134- 138 (Daurosides A,B) [https://doi.org/10.1007/BF00580545]
  57. Joseph-Nathan, P. et al., J. Het. Chem., 1984, 21, 1141- 1144 (pmr)
  58. Ueno, K., Acta Cryst. C, 1985, 41, 1786- 1789 (cryst struct) [https://doi.org/10.1107/S0108270185009453]
  59. Abu-Eittah, R.H. et al., Can. J. Chem., 1985, 63, 1173- 1179 (uv) [https://doi.org/10.1139/v85-200]
  60. Asheervadam, Y. et al., Fitoterapia, 1986, 57, 231- 234 (Adicardin)
  61. Talapatra, B. et al., Indian J. Chem., Sect. B, 1986, 25, 1122- 1125 (synth)
  62. Ulubelen, A. et al., J. Nat. Prod., 1986, 49, 692- 694 (Ac) [https://doi.org/10.1021/np50046a026]
  63. Gray, A.I. et al., Phytochemistry, 1987, 26, 257- 260 (Coleonema calycinum constits) [https://doi.org/10.1016/S0031-9422(00)81523-X]
  64. Gawron, A. et al., Planta Med., 1987, 53, 526- 529 (activity) [https://doi.org/10.1055/s-2006-962801]
  65. Ford, R.A. et al., Food Chem. Toxicol., 1988, 26, 375 (Me ether, rev, tox)
  66. Jain, A.K. et al., Indian J. Pharm. Sci., 1989, 51, 32- 35 (Rutinosylumbelliferone)
  67. Mericli, A.H., Int. J. Crude Drug Res., 1990, 28, 145- 147 (Me ether, isol)
  68. Ishii, H. et al., Chem. Pharm. Bull., 1991, 39, 3100- 3102 (Me ether, synth) [https://doi.org/10.1248/cpb.39.3100]
  69. Machida, K. et al., Chem. Pharm. Bull., 1993, 41, 248- 251 (6-caffeoylglucoside) [https://doi.org/10.1248/cpb.41.248]
  70. Yang, L. et al., Indian J. Chem., Sect. B, 1995, 34, 975- 977 (Crellisin B)
  71. Yang, X. et al., J. Chin. Pharm. Sci., 1996, 5, 68- 73 (Marminal)
  72. Silvan, A.M. et al., J. Nat. Prod., 1996, 59, 1183- 1185 (Me ether, activity) [https://doi.org/10.1021/np960422f]
  73. Pachaly, P. et al., Pharmazie, 1996, 51, 57- 61 (Isoadicardin)
  74. Kofinas, C. et al., Planta Med., 1998, 64, 174- 176 (activity) [https://doi.org/10.1055/s-2006-957398]
  75. Latip, J. et al., Phytochemistry, 1999, 51, 107- 110 (O-methoxycarbonylbutyl) [https://doi.org/10.1016/S0031-9422(98)00720-1]
  76. Jiang, Z.-H. et al., Chem. Pharm. Bull., 2002, 50, 137- 139 (6-xylosylglucoside) [https://doi.org/10.1248/cpb.50.137]
  77. Murray, R.D.H., Prog. Chem. Org. Nat. Prod., 2002, 83, 1- 619 (rev)
  78. Trost, B.M. et al., JACS, 2003, 125, 4518- 4526 (Me ether, synth) [https://doi.org/10.1021/ja0286573]
  79. Kuo, P.-C. et al., Planta Med., 2004, 70, 183- 185 (Phellodenol D)
  80. Torres, R. et al., Phytochemistry, 2006, 67, 984- 987 (6-Deoxyhaplopinol) [https://doi.org/10.1016/j.phytochem.2006.03.016]
  81. Benkiki, N. et al., Chem. Nat. Compd. (Engl. Transl.), 2007, 43, 612- 613 (3,4-Dihydroherniarin) [https://doi.org/10.1007/s10600-007-0205-z]
  82. Zhu, Y. et al., Helv. Chim. Acta, 2008, 91, 1894- 1901 (6-acetylglucoside)
  83. Dugo, P. et al., J. Agric. Food Chem., 2009, 57, 6543- 6551 (Me ether, detn, lime) [https://doi.org/10.1021/jf901209r]
  84. Li, W. et al., J. Asian Nat. Prod. Res., 2009, 11, 720- 727 (Adicardin, synth)
  85. Srivastava, A. et al., Synth. Commun., 2010, 40, 1765- 1771 (synth, pmr, cmr)
  86. Kutubi, M.S. et al., Synthesis, 2011, 1283- 1289 (synth, pmr, cmr, Me ether)
  87. Leão, R.A.C. et al., Synthesis, 2011, 3692- 3696 (synth, ir, uv, pmr, Me ether)
  88. Shi, J. et al., Planta Med., 2012, 78, 1844- 1850 (Hydrangea glycosides)
  89. Cao, J.-L et al., Org. Lett., 2013, 15, 3856- 3859 (synth, pmr, cmr) [https://doi.org/10.1021/ol401581p]
  90. Razavi, S.M. et al., Nat. Prod. Res., 2015, 29, 717- 721 (Ferulone C)
  91. Saitoh, T. et al., Tet. Lett., 1975, 16, 4461- 4462 (Licochalcone A) [https://doi.org/10.1016/S0040-4039(00)91092-X]
  92. Saitoh, T. et al., Tet. Lett., 1975, 16, 4463- 4466 (Licochalcone A, biosynth) [https://doi.org/10.1016/S0040-4039(00)91093-1]
  93. Khan, S.A. et al., Indian J. Chem., Sect. B, 1983, 22, 276- 277 (synth)
  94. Hatano, T. et al., Chem. Pharm. Bull., 1988, 36, 2090- 2097 (Licochalcone A) [https://doi.org/10.1248/cpb.36.2090]
  95. Hatano, T. et al., Chem. Pharm. Bull., 1988, 36, 2286- 2288 (activity) [https://doi.org/10.1248/cpb.36.2286]
  96. Shibata, S. et al., Planta Med., 1991, 57, 221- 224 (pharmacol) [https://doi.org/10.1055/s-2006-960078]
  97. Kajiyama, K. et al., Phytochemistry, 1992, 31, 3329- 3232 (Licochalcone A, uv) [https://doi.org/10.1016/0031-9422(92)83481-D]
  98. Islam, A. et al., Indian J. Chem., Sect. B, 1993, 32, 713- 715 (Licochalcone A, synth)
  99. Chen, M. et al., Antimicrob. Agents Chemother., 1994, 38, 1339- 1344 (activity) [https://doi.org/10.1128/AAC.38.6.1339]
  100. Feldbaek, N. et al., Bioorg. Med. Chem. Lett., 1995, 5, 449- 452 (Licochalcone C, synth)
  101. Park, E.J. et al., Planta Med., 1998, 64, 464- 466 (Pogostemon cablin constit) [https://doi.org/10.1055/s-2006-957485]
  102. Zhang, W. et al., Chem. Pharm. Bull., 2006, 54, 1037- 1039 (Euphorbia heliscopia constit) [https://doi.org/10.1248/cpb.54.1037]
  103. Mahmoudi, N. et al., Antimicrob. Agents Chemother., 2008, 52, 1215- 1220 (activity) [https://doi.org/10.1128/AAC.01043-07]
  104. Yo, Y.-T. et al., J. Agric. Food Chem., 2009, 57, 8266- 8273 (biol)
  105. Dao, T.T. et al., Bioorg. Med. Chem. Lett., 2011, 21, 294- 298 (Licochalcones A,G, activity) [https://doi.org/10.1016/j.bmcl.2010.11.016]
  106. Liu, Z. et al., Bioorg. Med. Chem. Lett., 2011, 21, 3755- 3758 (activity) [https://doi.org/10.1016/j.bmcl.2011.04.057]
  107. Messier, C. et al., Mycoses, 2011, 54, 801- 806 (activity)
  108. Jeon, J.-H. et al., Synthesis, 2011, 370- 376 (synth)
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  110. Yun, S.R. et al., Bull. Korean Chem. Soc., 2015, 36, 2784- 2787 (synth)
[top⬆]
Trypanocidal Citations
  1. Maiti, B.C. et al., Experientia, 1976, 32, 1106- 1107 (Cytoseira constit) [https://doi.org/10.1007/BF01927569]
  2. Cox, R.E. et al., JCS Perkin 1, 1976, 578- 580 (Aspergillus constit) [https://doi.org/10.1039/p19760000578]
  3. McCorkindale, N.J. et al., Tetrahedron, 1978, 34, 2791- 2795 (synth, ms, pmr, ir) [https://doi.org/10.1016/0040-4020(78)88421-X]
  4. Banerji, A. et al., Phytochemistry, 1981, 20, 2217- 2220 (isol, synth, pmr, cmr, ms) [https://doi.org/10.1016/0031-9422(81)80116-1]
  5. Noguchi, M., Chem. Pharm. Bull., 1984, 32, 3584- 3587 (Lyciumamide) [https://doi.org/10.1248/cpb.32.3584]
  6. Wahidulla, S. et al., Phytochemistry, 1991, 30, 3323- 3325 (Aurantiamide acetate,Diaaurantiamide acetate, isol, Acanthophora) [https://doi.org/10.1016/0031-9422(91)83202-V]
  7. Banerji, A. et al., Indian J. Chem., Sect. B, 1993, 32, 776- 778 (Benzoylaurantiamide)
  8. Ferreira, D.T. et al., J. Braz. Chem. Soc., 1995, 6, 323- 326 (Benzoylaurantiamide) [https://doi.org/10.5935/0103-5053.19950054]
  9. Ragasa, C.Y. et al., Philipp. J. Sci., 1998, 127, 267- 276 (activity)
  10. Lu, H. et al., Planta Med., 1999, 65, 586 (Asperglaucide, isol, activity) [https://doi.org/10.1055/s-2006-960835]
  11. Hayashi, Y. et al., JOC, 2000, 65, 8402- 8405 (synth) [https://doi.org/10.1021/jo0012905]
  12. Isshiki, K. et al., Biosci., Biotechnol., Biochem., 2001, 65, 1195- 1197 (isol) [https://doi.org/10.1271/bbb.65.1195]
  13. Suhas, R. et al., Chem. Biol. Drug Des., 2012, 79, 850- 862 (analogues)
  14. Nwodo, N.J. et al., Molecules, 2014, 19, 5470- 5477 (Zapoteca constit, activity)
  15. Zhao, M. et al., J. Antibiot., 2016, 69, 571- 573 (Benzoylaurantiamide)
[top⬆]
Anthelmintic Citations
  1. Attah SK, Ayeh-Kumi PF, Sittie AA, Oppong IV, Nyarko AK. Extracts of Euphorbia hirta Linn. (Euphorbiaceae) and Rauvolfia vomitoria Afzel (Apocynaceae) demonstrate activities against Onchocerca volvulus microfilariae in vitro. BMC Complement Altern Med. 2013 Mar 18;13:66. [https://doi.org/10.1186/1472-6882-13-66.] PubMed PMID: 23506674; PubMed Central PMCID: PMC3606627.
  2. Lone BA, Bandh SA, Chishti MZ, Bhat FA, Tak H, Nisa H. Anthelmintic and antimicrobial activity of methanolic and aqueous extracts of Euphorbia helioscopia L. Trop Anim Health Prod. 2013 Mar;45(3):743-9. [https://doi.org/10.1007/s11250-012-0283-1.] Epub 2012 Oct 12. PubMed PMID: 23065392.
  3. Lone BA, Chishti MZ, Bhat FA, Tak H, Bandh SA. In vitro and in vivo anthelmintic activity of Euphorbia helioscopia L. Vet Parasitol. 2012 Oct 26;189(2-4):317-21. [https://doi.org/10.1016/j.vetpar.2012.04.023.] Epub 2012 Apr 25. PubMed PMID: 22633018.
  4. Sharma SK, Singh S, Singh J. Anthelmintic effect of Euphorbia prostrata Ait. extracts. Indian J Pharmacol. 2011 Nov;43(6):743-4. [https://doi.org/10.4103/0253-7613.89846.] PubMed PMID: 22144794; PubMed Central PMCID: PMC3229805.
  5. Shi J, Li Z, Nitoda T, Izumi M, Kanzakia H, Baba N, Kawazu K, Nakajima S. Antinematodal activities of ingenane diterpenes from Euphorbia kansui and their derivatives against the pine wood nematode (Bursaphelenchus xylophilus). Z Naturforsch C. 2008 Jan-Feb;63(1-2):59-65. PubMed PMID: 18386489.
  6. Shi JX, Li ZX, Nitoda T, Izumi M, Kanzaki H, Baba N, Kawazu K, Nakajima S. Three antinematodal diterpenes from Euphorbia kansui. Biosci Biotechnol Biochem. 2007 Apr;71(4):1086-9. Epub 2007 Apr 7. PubMed PMID: 17420578.
[top⬆]
Insecticidal Citations
  1. Kitajima S, Miura K, Aoki W, Yamato KT, Taira T, Murakami R, Aburaya S. Transcriptome and proteome analyses provide insight into laticifer's defense of Euphorbia tirucalli against pests. Plant Physiol Biochem. 2016 Nov;108:434-446. [https://doi.org/10.1016/j.plaphy.2016.08.008.] Epub 2016 Aug 18. PubMed PMID: 27566924.
  2. Cristina RT, Morariu S, Cernea MS, Dumitrescu E, Muselin F, Cumpanaşoiu C. Phytotherapeutic activity of Euphorbia cyparissias extracts on Ixodidae (Acari) female ticks. Afr J Tradit Complement Altern Med. 2014 Jun 4;11(4):48-53. eCollection 2014. PubMed PMID: 25392580; PubMed Central PMCID: PMC4202396.
  3. Panneerselvam C, Murugan K, Kovendan K, Kumar PM, Subramaniam J. Mosquito larvicidal and pupicidal activity of Euphorbia hirta Linn. (Family: Euphorbiaceae) and Bacillus sphaericus against Anopheles stephensi Liston. (Diptera: Culicidae). Asian Pac J Trop Med. 2013 Feb;6(2):102-9. [https://doi.org/10.1016/S1995-7645(13)60003-6.] PubMed PMID: 23339910.
  4. Priyadarshini KA, Murugan K, Panneerselvam C, Ponarulselvam S, Hwang JS, Nicoletti M. Biolarvicidal and pupicidal potential of silver nanoparticles synthesized using Euphorbia hirta against Anopheles stephensi Liston (Diptera: Culicidae). Parasitol Res. 2012 Sep;111(3):997-1006. [https://doi.org/10.1007/s00436-012-2924-8.] Epub 2012 May 6. PubMed PMID: 22562234.
  5. Zahir AA, Rahuman AA. Evaluation of different extracts and synthesised silver nanoparticles from leaves of Euphorbia prostrata against Haemaphysalis bispinosa and Hippobosca maculata. Vet Parasitol. 2012 Jul 6;187(3-4):511-20. [https://doi.org/10.1016/j.vetpar.2012.02.001.] Epub 2012 Feb 14. PubMed PMID: 22429701.
  6. Geng ZF, Liu ZL, Wang CF, Liu QZ, Shen SM, Liu ZM, Du SS, Deng ZW. Feeding deterrents against two grain storage insects from Euphorbia fischeriana. Molecules. 2011 Jan 10;16(1):466-76. [https://doi.org/10.3390/molecules16010466.] PubMed PMID: 21221063; PubMed Central PMCID: PMC6259572.
  7. Sharma P, Mohan L, Srivastava CN. Amaranthus oleracea and Euphorbia hirta: natural potential larvicidal agents against the urban Indian malaria vector, Anopheles stephensi Liston (Diptera: Culicidae). Parasitol Res. 2009 Dec;106(1):171-6. [https://doi.org/10.1007/s00436-009-1644-1.] Epub 2009 Oct 17. PubMed PMID: 19838734.
  8. Rahuman AA, Gopalakrishnan G, Venkatesan P, Geetha K. Larvicidal activity of some Euphorbiaceae plant extracts against Aedes aegypti and Culex quinquefasciatus (Diptera: Culicidae). Parasitol Res. 2008 Apr;102(5):867-73. Epub 2007 Dec 29. PubMed PMID: 18163189.
  9. Shi J, Li Z, Izumi M, Baba N, Nakajima S. Termiticidal activity of diterpenes from the roots of Euphorbia kansui. Z Naturforsch C. 2008 Jan-Feb;63(1-2):51-8. PubMed PMID: 18386488.
[top⬆]

Inquiries regarding the purchase of Plant cell lines or other PCCL services can be directed to Michael Daley mpdaley@umass.edu

Acknowledgements

The establishment of the PCCL has been sponsored by National Science Foundation (NSF/DBI-156 1572), United States Department of Agriculture Massachusetts Experiment Station Award (MAS00496), the Science and Technology fund from the President's office of the University of Massachusetts, and the 2016 UMass Amherst Armstrong Fund for Science.

National Science FoundationCenter for Agriculture, Food and the Environment

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