The University of Massachusetts Amherst

The Plant Cell Culture Library

Hibiscus engleri
Cell Line ID HE-04401
Media Type B88
Lowest Tolerable USDA Zone 9a
Drought Tolerance Not tolerant
Availability Low
Order Malvales
Family Malvaceae
Genus Hibiscus
Antiviral Genus Level ➡ 5 citations
Antibacterial Genus Level ➡ 49 citations
Antifungal Genus Level ➡ 20 citations
Trypanocidal Genus Level ➡ 1 citations
Insecticidal Genus Level ➡ 1 citations
Anticancer Genus Level ➡ 14 citations
Plant Habit Herb Perennial
Plant Habitat SubTrop/Trop
Culture Start Material Seed
Plant Supplier Comm/Silverhill Seeds, South Africa
Antiviral Citations
  1. Hassan STS, Švajdlenka E, Berchová-Bímová K. Hibiscus sabdariffa L. and Its Bioactive Constituents Exhibit Antiviral Activity against HSV-2 and Anti-enzymatic Properties against Urease by an ESI-MS Based Assay. Molecules. 2017 Apr 30;22(5). pii: E722. [https://doi.org/10.3390/molecules22050722.] PubMed PMID: 28468298.
  2. Baatartsogt T, Bui VN, Trinh DQ, Yamaguchi E, Gronsang D, Thampaisarn R, Ogawa H, Imai K. High antiviral effects of hibiscus tea extract on the H5 subtypes of low and highly pathogenic avian influenza viruses. J Vet Med Sci. 2016 Oct 1;78(9):1405-1411. Epub 2016 May 19. PubMed PMID: 27193820; PubMed Central PMCID: PMC5059367.
  3. D'Souza DH, Dice L, Davidson PM. Aqueous Extracts of Hibiscus sabdariffa Calyces to Control Aichi Virus. Food Environ Virol. 2016 Jun;8(2):112-9. [https://doi.org/10.1007/s12560-016-9229-5.] Epub 2016 Feb 18. PubMed PMID: 26892338.
  4. Joshi SS, Dice L, D'Souza DH. Aqueous Extracts of Hibiscus sabdariffa Calyces Decrease Hepatitis A Virus and Human Norovirus Surrogate Titers. Food Environ Virol. 2015 Dec;7(4):366-73. [https://doi.org/10.1007/s12560-015-9209-1.] Epub 2015 Jul 5. PubMed PMID: 26143492.
  5. Lam SK, Ng TB. Novel galactonic acid-binding hexameric lectin from Hibiscus mutabilis seeds with antiproliferative and potent HIV-1 reverse transcriptase inhibitory activities. Acta Biochim Pol. 2009;56(4):649-54. Epub 2009 Dec 4. PubMed PMID: 19956805.
[top⬆]
Antibacterial Citations
  1. Aldrich Library of FT-IR Spectra, 1st edn., 1985, 1, 149B (ir)
  2. Aldrich Library of FT-IR Spectra: Vapor Phase, 1989, 3, 219D, 220A (ir)
  3. Aldrich Library of 13C and 1H FT-NMR Spectra, 1992, 1, 226B, 226C (nmr)
  4. Cramer, F. et al., Annalen, 1962, 654, 180- 188 (phosphate, synth, ir)
  5. Bates, R.B. et al., JOC, 1963, 28, 1086- 1089 (isol, struct) [https://doi.org/10.1021/jo01039a054]
  6. Krishna, G. et al., Arch. Biochem. Biophys., 1966, 114, 200 (diphosphate, synth) [https://doi.org/10.1016/0003-9861(66)90322-5]
  7. Burrell, J.W.K. et al., JCS(C), 1966, 2144- 2154 (config, bibl)
  8. Corey, E.J. et al., JACS, 1967, 89, 4245- 4247 (synth) [https://doi.org/10.1021/ja00992a065]
  9. Dugan, R.E. et al., Anal. Biochem., 1968, 22, 249- 259 (phosphate) [https://doi.org/10.1016/0003-2697(68)90314-X]
  10. Hill, H.C. et al., JCS(C), 1968, 93- 108 (ms)
  11. Miller, J.A. et al., JCS(C), 1968, 1837- 1843 (phosphate)
  12. Popják, G., Methods Enzymol., 1969, 15, 393 (diphosphate, enzymic synth) [https://doi.org/10.1016/S0076-6879(69)15014-4]
  13. Richards, J.B. et al., Biochem. J., 1972, 128, 1345- 1352 (biosynth) [https://doi.org/10.1042/bj1281345]
  14. Jacob, G. et al., Phytochemistry, 1972, 11, 1683- 1688 (biosynth) [https://doi.org/10.1016/0031-9422(72)85019-2]
  15. Evans, R.H. et al., Chem. Comm., 1973, 465 (pyrophosphate, biosynth) [https://doi.org/10.1039/c3973000465a]
  16. Morris, W.W., J. Assoc. Off. Anal. Chem., 1973, 56, 1037- 1064 (ir)
  17. Tengo, J. et al., J. Chem. Ecol., 1975, 1, 253- 268 (hexanoyl, isol) [https://doi.org/10.1007/BF00987874]
  18. Crombie, L. et al., JCS Perkin 1, 1975, 913- 915 (cmr) [https://doi.org/10.1039/p19750000913]
  19. Cardillo, C.R. et al., Chem. Comm., 1976, 190 (synth) [https://doi.org/10.1039/c39760000190]
  20. Pauling, H. et al., Helv. Chim. Acta, 1976, 59, 1233- 1243 (synth)
  21. Larkin, J.P. et al., JCS Perkin 1, 1976, 2524 (phosphate) [https://doi.org/10.1039/p19760002524]
  22. Org. Synth., 1977, 56, 112- 117 (synth, ir) [https://doi.org/10.15227/orgsyn.056.0112]
  23. Pickett, J.A. et al., J. Chem. Ecol., 1980, 6, 425- 434 (isol) [https://doi.org/10.1007/BF01402919]
  24. Dixit, V.M. et al., JOC, 1981, 46, 1967- 1969 (diphosphate, synth, pmr, P-31 nmr) [https://doi.org/10.1021/jo00322a060]
  25. Van Tamelen, E.E. et al., Bioorg. Chem., 1982, 11, 133- 170 (synth) [https://doi.org/10.1016/0045-2068(82)90025-6]
  26. Wheller, J.W. et al., J. Chem. Ecol., 1982, 8, 821- 835 (isol)
  27. Bohlmann, F. et al., Phytochemistry, 1982, 21, 2537- 2539 (angelate) [https://doi.org/10.1016/0031-9422(82)85252-7]
  28. Amin, C et al., Helv. Chim. Acta, 1984, 67, 1540- 1546 (synth, ir, pmr, ms)
  29. Cane, D.E., Acta Cryst., 1985, 18, 220- 226 (diphosphate, biosynth, rev)
  30. Yamagisawa, A. et al., Chem. Lett., 1988, 1899- 1902 (synth) [https://doi.org/10.1246/cl.1988.1899]
  31. Andersen, J.F. et al., J. Chem. Ecol., 1988, 14, 1153- 1162 (Farnesal, isol) [https://doi.org/10.1007/BF01019343]
  32. Yoshioka, T. et al., Phytochemistry, 1990, 29, 3469 (biosynth) [https://doi.org/10.1016/0031-9422(90)85259-I]
  33. Shindo, T. et al., Experientia, 1992, 48, 688- 690 (Sinularia glycoside)
  34. Zhang, D. et al., Anal. Biochem., 1993, 213, 356- 361 (phosphates, hplc) [https://doi.org/10.1006/abio.1993.1432]
  35. Christensen, D.J. et al., Bioorg. Med. Chem., 1994, 2, 631 (synth) [https://doi.org/10.1016/0968-0896(94)85011-9]
  36. Encyclopedia of Food and Color Additives, (ed. Burdock, G.A.), CRC Press, 1997, 1059- 1060
  37. Shao, Y. et al., Org. Lett., 1999, 1, 627- 630 (diphosphates, synth) [https://doi.org/10.1021/ol990714i]
  38. Leyes, A.E. et al., Org. Lett., 1999, 1, 1071- 1074 (biosynth) [https://doi.org/10.1021/ol990876e]
  39. Adesanya, S.A. et al., Phytochemistry, 1999, 51, 1039- 1041 (Rubiginoside) [https://doi.org/10.1016/S0031-9422(98)00701-8]
  40. Thai, L. et al., Proc. Natl. Acad. Sci. U.S.A., 1999, 96, 13080- 13085 (phosphate, biosynth)
  41. Yu, J.S. et al., Org. Lett., 2005, 7, 4803- 4806 (synth)
  42. Magid, A.A. et al., Phytochemistry, 2005, 66, 2714- 2718 (Crenulatosides A-D) [https://doi.org/10.1016/j.phytochem.2005.09.009]
  43. Éparvier, V. et al., Phytochemistry, 2007, 68, 604- 608 (Pancherins A,B) [https://doi.org/10.1016/j.phytochem.2006.11.008]
  44. Xiao, Y. et al., J. Chem. Ecol., 2009, 35, 769- 778 (Farnesyl acetate)
  45. Fenaroli's Handbook of Flavor Ingredients, 6th edn., (ed. Burdock, G.A.), CRC Press, 2010, 1944- 1945 (Farnesyl acetate, use)
  46. Kaneko, M. et al., J. Antibiot., 2011, 64, 547- 549 (activity)
  47. Lee, T.-H. et al., J. Nat. Prod., 2011, 74, 1561- 1567 (Cosmosporaside A) [https://doi.org/10.1021/np200056e]
  48. Liu, J. et al., Org. Lett., 2013, 15, 5150- 5153 (aldehyde) [https://doi.org/10.1021/ol402434x]
  49. Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, FAB800
[top⬆]
Antifungal Citations
  1. Haynes, H.F. et al., Aust. J. Sci. Res., Ser. A, 1952, 5, 387- 400 (isol, uv, struct, oxide)
  2. Cannon, J.R. et al., Aust. J. Chem., 1956, 6, 86- 89 (isol) [https://doi.org/10.1071/CH9530086]
  3. Rosenkranz, H.J. et al., Annalen, 1966, 691, 159- 164 (synth, uv, ir)
  4. Mitscher, L.A. et al., Heterocycles, 1975, 3, 7- 14 (synth) [https://doi.org/10.3987/R-1975-01-0007]
  5. Oehl, R. et al., Chem. Ber., 1976, 109, 705- 709 (synth, uv, ir, ms)
  6. Ohmoto, T. et al., Chem. Pharm. Bull., 1976, 24, 1532- 1536; 1981, 29, 390 - 395 (isol, uv,ir, pmr, ms, synth, oxide) [https://doi.org/10.1248/cpb.24.1532]
  7. Campos, O. et al., Heterocycles, 1980, 14, 975- 984 (synth)
  8. Forgacs, P. et al., Planta Med., 1982, 46, 187- 189 (isol) [https://doi.org/10.1055/s-2007-971212]
  9. Anderson, L.A. et al., J. Nat. Prod., 1983, 46, 374- 378 (isol, biochem) [https://doi.org/10.1021/np50027a014]
  10. Cain, M. et al., JACS, 1983, 105, 907- 913 (synth) [https://doi.org/10.1021/ja00342a045]
  11. Aragozzini, F. et al., Plant Cell Rep., 1988, 7, 213- 215 (biosynth) [https://doi.org/10.1007/BF00269327]
  12. Ohmoto, T. et al., Alkaloids (Academic Press), 1989, 36, 135- 170 (rev)
  13. He, W. et al., Meded. Fac. Landbouwwet., Rijksuniv. Gent, 1998, 64, 565- 569 (activity)
  14. Rossler, U. et al., Tet. Lett., 1999, 40, 7075- 7078 (synth) [https://doi.org/10.1016/S0040-4039(99)01472-0]
  15. Czerwinski, K.M. et al., Synth. Commun., 2003, 33, 1225- 1231 (synth, pmr, cmr)
  16. Bröckelmann, M.G. et al., Eur. J. Org. Chem., 2004, 4856- 4863 (isol, pmr, cmr, ms)
  17. Soriano-Agatón, F. et al., J. Nat. Prod., 2005, 68, 1581- 1587 (synth, pmr, cmr) [https://doi.org/10.1021/np050250z]
  18. Suzuki, H. et al., Synthesis, 2005, 28- 31 (synth, ir, pmr, cmr)
  19. Gollner, A. et al., Org. Lett., 2010, 12, 1352- 1355 (synth, ir, pmr, cmr, ms) [https://doi.org/10.1021/ol100300s]
  20. Dai, J. et al., Molecules, 2016, 21, 493:1- 13 (Canthin-6-ones, rev, synth, biosynth, activity)
[top⬆]
Trypanocidal Citations
  1. Umar IA, Maryoms NG, Daikwo E, Gidado A, Buratai LB, Igbokwe IO, Ibrahim MA. The effect of aqueous extracts of Hibiscus sabdariffa (Sorrel) calyces on heamatological profile and organ pathological changes in Trypanasoma congolense - infected rats.Afr J Tradit Complement Altern Med. 2009 Jul 3;6(4):585-91. PubMed PMID: 20606781; PubMed Central PMCID: PMC2816476.
[top⬆]
Insecticidal Citations
  1. Rahuman AA, Bagavan A, Kamaraj C, Saravanan E, Zahir AA, Elango G. Efficacy of larvicidal botanical extracts against Culex quinquefasciatus Say (Diptera: Culicidae). Parasitol Res. 2009 Jun;104(6):1365-72. [https://doi.org/10.1007/s00436-009-1337-9.] Epub 2009 Feb 7. PubMed PMID: 19198882.
[top⬆]
Anticancer Citations
  1. Yoshihara, T. et al., Agric. Biol. Chem., 1981, 45, 2593 (Grossamide, synth)
  2. Yoshihara, T. et al., Agric. Biol. Chem., 1983, 47, 217- 220 (Grossamide, config)
  3. Sakakibara, I. et al., Phytochemistry, 1991, 30, 3013- 3016 (Cannabis sativa constit) [https://doi.org/10.1016/S0031-9422(00)98242-6]
  4. Lajide, L. et al., Phytochemistry, 1995, 40, 1105- 1112 (Demethylgrossamide) [https://doi.org/10.1016/0031-9422(95)92653-P]
  5. Wang, M.F. et al., Chin. Chem. Lett., 1997, 8, 35- 36 (Tataramide B)
  6. Li, J.-X. et al., Planta Med., 1998, 64, 628- 631 (Tribulusamides A,B, activity)
  7. Seca, A.M.L. et al., Phytochemistry, 2001, 58, 1219- 1223 (Hibiscus cannabinus constit) [https://doi.org/10.1016/S0031-9422(01)00311-9]
  8. King, R.R. et al., Phytochemistry, 2005, 66, 2468- 2473 (E,Z-Grossamides, potato scab constit) [https://doi.org/10.1016/j.phytochem.2005.07.014]
  9. Ge, F. et al., Helv. Chim. Acta, 2008, 91, 1023- 1030 (Thoreliamide A)
  10. King, R.R. et al., Phytochemistry, 2010, 71, 2187- 2189 (Grossamide, potato constit) [https://doi.org/10.1016/j.phytochem.2010.09.020]
  11. Karim, A. et al., Helv. Chim. Acta, 2011, 94, 528- 533 (Dimorphamide A)
  12. Zhang, W.-N. et al., J. Agric. Food Chem., 2012, 60, 1682- 1687 (E,Z-Grossamides, activity) [https://doi.org/10.1021/jf2046784]
  13. Bolleddula, J. et al., Rapid Commun. Mass Spectrom., 2012, 26, 1277- 1290 (Withania somnifera constit)
  14. Sun, J. et al., Fitoterapia, 2014, 98, 110- 116 (Melongenamide B, activity) [https://doi.org/10.1016/j.fitote.2014.07.012]
[top⬆]