The University of Massachusetts Amherst

The Plant Cell Culture Library

Carissa haematocarpa
Cell Line ID CH-03910
Media Type B88
Lowest Tolerable USDA Zone 9b
Drought Tolerance Tolerant
Availability Low
Order Gentianales
Family Apocynaceae
Genus Carissa
Antiviral Genus Level ➡ 1 citations
Anticancer Genus Level ➡ 46 citations
Plant Habit Shrub/Tree Evergreen
Plant Habitat SubTrop/Trop
Culture Start Material Seed
Plant Supplier Comm/Silverhill Seeds , South Africa
Antiviral Citations
  1. Tolo FM, Rukunga GM, Muli FW, Njagi EN, Njue W, Kumon K, Mungai GM, Muthaura CN, Muli JM, Keter LK, Oishi E, Kofi-Tsekpo MW. Anti-viral activity of the extracts of a Kenyan medicinal plant Carissa edulis against herpes simplex virus. J Ethnopharmacol. 2006 Mar 8;104(1-2):92-9. Epub 2005 Sep 29. PubMed PMID: 16198524.
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Anticancer Citations
  1. Pal, R. et al., Phytochemistry, 1975, 14, 2302- 2303 (Carinol) [https://doi.org/10.1016/S0031-9422(00)91126-9]
  2. Achenbach, H. et al., Phytochemistry, 1983, 22, 749- 754 (Carissa edulis constit) [https://doi.org/10.1016/S0031-9422(00)86976-9]
  3. Khamlach, K. et al., Heterocycles, 1990, 31, 2195- 2199 (Carinol, synth)
  4. Kraus, R. et al., Phytochemistry, 1990, 29, 1653- 1659 (Urtica dioica constit, ms) [https://doi.org/10.1016/0031-9422(90)80140-C]
  5. Sefkow, M., JOC, 2001, 66, 2343- 2349 (Carinol, synth) [https://doi.org/10.1021/jo001547z]
  6. Rodriguez-Guzman, R. et al., Planta Med., 2011, 77, 1542- 1544 (Zanthoxylum monophyllum constit) [https://doi.org/10.1055/s-0030-1270782]
  7. He, W-J. et al., Phytochemistry, 2012, 83, 63- 69 (Cathaya argyrophylla constit)
  8. Wangteeraprasert, R. et al., Phytother. Res., 2012, 26, 1496- 1499 (Carissa spinarum constit, activity)
  9. Ao, W. et al., Zhongcaoyao, 2013, 44, 790- 793 (Syripinnalignans C,D,E)
  10. Burden, R.S. et al., Chem. Comm., 1969, 693- 701 (Helianthoidin)
  11. Nishibe, S. et al., Phytochemistry, 1971, 10, 2231- 2232 ((-)-Nortrachelogenin) [https://doi.org/10.1016/S0031-9422(00)97230-3]
  12. Nishibe, S. et al., Chem. Pharm. Bull., 1973, 21, 1108- 1113 (Tracheloside, Trachelogenin,Nortrachelogenin) [https://doi.org/10.1248/cpb.21.1108]
  13. Nishibe, S. et al., Chem. Pharm. Bull., 1973, 21, 1114- 1117 (Nortrachelogenin 4,4'-diglucoside) [https://doi.org/10.1248/cpb.21.1114]
  14. Tandon, S. et al., Phytochemistry, 1976, 15, 1789- 1791 ((+)-Wikstromol, synth) [https://doi.org/10.1016/S0031-9422(00)97493-4]
  15. Carnmalm, B. et al., Acta Chem. Scand., Ser. B, 1977, 31, 433 ((-)-Pinopalustrin, struct)
  16. Kato, A. et al., J. Nat. Prod., 1979, 42, 159- 162 ((+)-Nortrachelogenin) [https://doi.org/10.1021/np50002a004]
  17. Torrance, S.J. et al., J. Pharm. Sci., 1979, 68, 664- 666 (Wikstromol) [https://doi.org/10.1002/jps.2600680545]
  18. Lee, K.-H. et al., J. Nat. Prod., 1981, 44, 530- 535 ((+)-Nortrachelogenin, activity) [https://doi.org/10.1021/np50017a003]
  19. Achenbach, H. et al., Phytochemistry, 1983, 22, 749- 753 ((-)-Nortrachelogenin, Carissanol) [https://doi.org/10.1016/S0031-9422(00)86976-9]
  20. Abe, F. et al., Chem. Pharm. Bull., 1986, 34, 4340- 4345 (Trachelogenin 4-gentiobioside) [https://doi.org/10.1248/cpb.34.4340]
  21. Belletire, J.L. et al., JOC, 1988, 53, 4724- 4729 ((+)-Wikstromol, synth) [https://doi.org/10.1021/jo00255a012]
  22. Amaro-Luis, J.M. et al., Phytochemistry, 1988, 27, 3933- 3935 (Meridinol) [https://doi.org/10.1016/0031-9422(88)83048-6]
  23. Khamlach, K. et al., Heterocycles, 1990, 31, 2195- 2199 (Carissanol, synth)
  24. Belletire, J.L., J. Nat. Prod., 1990, 53, 1587- 1592 ((+)-Wikstromol, synth, cryst struct, bibl) [https://doi.org/10.1021/np50072a034]
  25. González, A.G. et al., Phytochemistry, 1990, 29, 1981- 1983 (Bupleurum salicifolium constits) [https://doi.org/10.1016/0031-9422(90)85051-G]
  26. Schröder, H.C., Z. Naturforsch., C, 1990, 45, 1215- 1221 (HIV activity)
  27. John, L.M.D. et al., J. Nat. Prod., 1992, 55, 1313- 1314 (Trachelogenin, cmr) [https://doi.org/10.1021/np50087a022]
  28. Khamlach, K. et al., Tetrahedron, 1992, 48, 10115- 10126 (Trachelogenin, (-)-Nortrachelogenin, (+)-Wikstromol, synth) [https://doi.org/10.1016/S0040-4020(01)89041-4]
  29. Estevez-Reyes, R. et al., J. Nat. Prod., 1993, 56, 1177- 1181 (Benchequiol) [https://doi.org/10.1021/np50097a026]
  30. Appendino, G. et al., J. Nat. Prod., 1994, 57, 607- 613 (Epinortrachelogenin) [https://doi.org/10.1021/np50107a007]
  31. Esterez-Braun, A. et al., Tetrahedron, 1994, 50, 5203- 5210 (Epinortrachelogenin) [https://doi.org/10.1016/S0040-4020(01)90430-2]
  32. Kuo, Y.H. et al., J. Nat. Prod., 1996, 59, 622- 624 (Saussurenoside) [https://doi.org/10.1021/np9603941]
  33. Moritani, Y. et al., JOC, 1996, 61, 6922- 6930 (Trachelogenin, Guayadequiol, synth) [https://doi.org/10.1021/jo9601932]
  34. Takano, D. et al., J. Het. Chem., 1999, 36, 221- 224 (Meridinol, synth, abs config)
  35. Barrero, A.F. et al., J. Nat. Prod., 1999, 62, 946- 948 (tetra-Me 8-Ac) [https://doi.org/10.1021/np980445p]
  36. Hu, K. et al., Planta Med., 2000, 66, 564- 567 ((+)-Nortrachelogenin, isol, activity) [https://doi.org/10.1055/s-2000-8601]
  37. Rastrelli, L. et al., J. Nat. Prod., 2001, 64, 79- 81 (Phenax angustifolius constits) [https://doi.org/10.1021/np000290x]
  38. Sefkow, M., JOC, 2001, 66, 2343- 2349 (synth) [https://doi.org/10.1021/jo001547z]
  39. Tan, X.-Q. et al., Planta Med., 2005, 71, 93- 95 (Trachelospermum 8-glucoside) [https://doi.org/10.1055/s-2005-837761]
  40. Sinkkonen, J. et al., Magn. Reson. Chem., 2006, 44, 633- 636 (Pinus sylvestris constit, pmr,cmr)
  41. Schmidt, T.J. et al., Nat. Prod. Res., 2006, 20, 443- 453 (Nortracheloside)
  42. Wangteeraprasert, R. et al., Helv. Chim. Acta, 2009, 92, 1217- 1223 (Carissa carandas constit)
  43. Chinese Pat., 2010, 101 787 004 (Daphnelignan A)
  44. Cuong, T.D. et al., Planta Med., 2011, 77, 66- 69 (Pulsatilla 8-glucoside) [https://doi.org/10.1055/s-0030-1250122]
  45. Wangteeraprasert, R. et al., Phytother. Res., 2012, 26, 1496- 1499 (Carissanol, activity)
  46. Lee, S. et al., Bioorg. Med. Chem. Lett., 2014, 24, 44- 48 (Pulsatilla koreana constit) [https://doi.org/10.1016/j.bmcl.2013.12.006]
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