The University of Massachusetts Amherst

The Plant Cell Culture Library

Arctium lappa
Cell Line ID AL-01796-L1
Media Type M62
Lowest Tolerable USDA Zone 2a
Drought Tolerance Average
Availability medium
Order Asterales
Family Compositae
Genus Arctium
Antiviral Species Level ➡ 1 citations
Antibacterial Species Level ➡ 3 citations
Antifungal Species Level ➡ 1 citations
Insecticidal Species Level
Anticancer Species Level ➡ 79 citations
Culture Start Material Suspension Callus
Antiviral Citations
  1. Dias MM, Zuza O, Riani LR, de Faria Pinto P, Pinto PLS, Silva MP, de Moraes J, Ataíde ACZ, de Oliveira Silva F, Cecílio AB, Da Silva Filho AA. In vitro schistosomicidal and antiviral activities of Arctium lappa L. (Asteraceae) against Schistosoma mansoni and Herpes simplex virus-1. Biomed Pharmacother. 2017 Oct;94:489-498. [https://doi.org/10.1016/j.biopha.2017.07.116.] Epub 2017 Aug 3. PubMed PMID: 28780467.
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Antibacterial Citations
  1. Lou Z, Li C, Kou X, Yu F, Wang H, Smith GM, Zhu S. Antibacterial, Antibiofilm Effect of Burdock (Arctium lappa L.) Leaf Fraction and Its Efficiency in Meat Preservation. J Food Prot. 2016 Aug;79(8):1404-9. [https://doi.org/10.4315/0362-028X.JFP-15-576.] PubMed PMID: 27497128.
  2. Gentil M, Pereira JV, Sousa YT, Pietro R, Neto MD, Vansan LP, de Castro França S. In vitro evaluation of the antibacterial activity of Arctium lappa as a phytotherapeutic agent used in intracanal dressings. Phytother Res. 2006 Mar;20(3):184-6. PubMed PMID: 16521107.
  3. Pereira JV, Bergamo DC, Pereira JO, França Sde C, Pietro RC, Silva-Sousa YT. Antimicrobial activity of Arctium lappa constituents against microorganisms commonly found in endodontic infections. Braz Dent J. 2005;16(3):192-6. Epub 2006 Jan 12. PubMed PMID: 16429183.
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Antifungal Citations
  1. Fierascu RC, Georgiev MI, Fierascu I, Ungureanu C, Avramescu SM, Ortan A, Georgescu MI, Sutan AN, Zanfirescu A, Dinu-Pirvu CE, Velescu BS, Anuta V. Mitodepressive, antioxidant, antifungal and anti-inflammatory effects of wild-growing Romanian native Arctium lappa L. (Asteraceae) and Veronica persica Poiret (Plantaginaceae). Food Chem Toxicol. 2018 Jan;111:44-52. [https://doi.org/10.1016/j.fct.2017.11.008.] Epub 2017 Nov 7. PubMed PMID: 29126799.
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Anticancer Citations
  1. Suchý, M. et al., Tet. Lett., 1964, 3907- 3911 (Arctiopicrin) [https://doi.org/10.1016/S0040-4039(01)93314-3]
  2. Droźdź, B. et al., Coll. Czech. Chem. Comm., 1968, 33, 1730- 1737; 1972, 37, 1546 - 1554 (Onopordopicrin, Eupatoriopicrin)
  3. Samek, Z. et al., Tet. Lett., 1969, 10, 2931- 2934 (Cnicin) [https://doi.org/10.1016/S0040-4039(01)88311-8]
  4. Yoshioka, H. et al., Chem. Comm., 1970, 148- 149 (Salonitenolide) [https://doi.org/10.1039/C29700000148]
  5. Tori, K. et al., JCS(B), 1971, 1084- 1088 (Cnicin, config)
  6. Geissman, T.A., Phytochemistry, 1971, 10, 1075- 1077 (Eupatoriopicrin, occur) [https://doi.org/10.1016/S0031-9422(00)89941-0]
  7. Vanhaelen-Fastré, R. et al., Planta Med., 1974, 26, 375- 379; 1976, 29, 179 - 189 (Salonitenolide, isol, activity) [https://doi.org/10.1055/s-0028-1099402]
  8. Zakirov, S.Kh. et al., Chem. Nat. Compd. (Engl. Transl.), 1975, 11, 690 (Salonitenolide, isol,pmr, ir)
  9. Herz, W. et al., Phytochemistry, 1975, 14, 1561- 1567 (Eleagnin, Liscundin: Liscunditrin) [https://doi.org/10.1016/0031-9422(75)85351-9]
  10. Herz, W. et al., JOC, 1976, 41, 1015- 1020 (Eupassopin, Eupassofilin) [https://doi.org/10.1021/jo00868a022]
  11. Lee, K.H. et al., Tet. Lett., 1976, 17, 1051- 1054 (Eupassopin, cryst struct) [https://doi.org/10.1016/S0040-4039(00)93748-1]
  12. Guerrero, C. et al., Rev. Cubana Quim., 1977, 8, 123- 127 (Euparhombin, struct, activity)
  13. Hall, I.H. et al., J. Pharm. Sci., 1978, 67, 1235- 1235 (Euopahyssopin, activity) [https://doi.org/10.1002/jps.2600670912]
  14. Ito, K. et al., Chem. Lett., 1979, 8, 1503- 1506 (Eupatoriopicrin, cmr) [https://doi.org/10.1246/cl.1979.1503]
  15. Herz, W. et al., JOC, 1979, 44, 2784- 2788 (Euserotin, isol, struct) [https://doi.org/10.1021/jo01329a039]
  16. Bohlmann, F. et al., Phytochemistry, 1979, 18, 95- 98; 1982, 21, 647 - 651 (Amarin, isol) [https://doi.org/10.1016/S0031-9422(00)90921-X]
  17. González, A.G. et al., An. Quim., 1980, 76, 296- 297 (Amarin, isol)
  18. Herz, W. et al., Phytochemistry, 1983, 22, 513- 521 (Liatris mucronata constit) [https://doi.org/10.1016/0031-9422(83)83036-2]
  19. Bohlmann, F. et al., Annalen, 1984, 240- 249 (Cronquistianthus chachapoyensis constits)
  20. El-Masry, S. et al., Phytochemistry, 1985, 24, 999- 1001 (Centaurea glomerata constits,pmr) [https://doi.org/10.1016/S0031-9422(00)83170-2]
  21. Huneck, S. et al., Planta Med., 1986, 52, 398- 399 (Centaurea stoebe constits) [https://doi.org/10.1055/s-2007-969196]
  22. Jakupovic, J. et al., Planta Med., 1986, 52, 399- 401 (Acetylcnicin, struct) [https://doi.org/10.1055/s-2007-969197]
  23. Barrero, A.F. et al., An. Quim., Ser. C, 1988, 84, 344- 347 (Acetylcnicin, isol)
  24. Miski, M. et al., Phytochemistry, 1988, 27, 1417- 1420 (Arctiopicrin, isol, pmr) [https://doi.org/10.1016/0031-9422(88)80207-3]
  25. Maurizio, B. et al., Phytochemistry, 1988, 27, 1873- 1875 (Acetylcnicin, isol, struct)
  26. Turdybekov, K.M. et al., Chem. Nat. Compd. (Engl. Transl.), 1989, 25, 662- 665 (Salonitenolide, isol, cryst struct)
  27. Martinez-Vázquez, M. et al., J. Nat. Prod., 1991, 54, 1642- 1644 (Euparhombin, struct) [https://doi.org/10.1021/np50078a024]
  28. Lonergan, G. et al., J. Nat. Prod., 1992, 55, 225- 228 (Onopordopicrin, struct, activity) [https://doi.org/10.1021/np50080a012]
  29. Cardona, L. et al., Nat. Prod. Lett., 1994, 5, 47- 54 (Centaurea paui constits, struct)
  30. Bruno, M. et al., Phytochemistry, 1994, 35, 1371- 1377 (Centaurea sphaerocephala constits) [https://doi.org/10.1016/S0031-9422(06)80129-9]
  31. Lu, T. et al., Phytochemistry, 1994, 37, 1295- 1299 (Ohlingerin, Liscunditrin, cryst struct)
  32. Maldonado, E. et al., Phytochemistry, 1995, 38, 1265- 1267 (15-Acetoxy-8α-hydroxycostunolide, struct) [https://doi.org/10.1016/0031-9422(94)00752-F]
  33. Robles, M. et al., Planta Med., 1995, 61, 199- 203 (Eupatoriopicrin, rev, activity) [https://doi.org/10.1055/s-2006-958055]
  34. García, B. et al., Phytochemistry, 1996, 41, 1113- 1117 (hydroxymethylbutenoyl, struct) [https://doi.org/10.1016/0031-9422(95)00776-8]
  35. Cardona, L. et al., Annalen, 1997, 527- 532 (Centaurea paui constit)
  36. Cardona, L. et al., Liebigs Ann./Recl., 1997, 527- 532 (Centaurea paui constits, struct)
  37. Lazari, D. et al., Phytochemistry, 1998, 47, 415- 422 (Onopordon laconicum constit,Onopordon sibthorpianum constit) [https://doi.org/10.1016/S0031-9422(97)00587-6]
  38. Neves, M. et al., Phytochemistry, 1999, 50, 967- 972 (8-Acetylsalonitenolide,Diacetylsalonitenolide) [https://doi.org/10.1016/S0031-9422(98)00648-7]
  39. Skaltsa, H. et al., Phytochemistry, 2000, 55, 903- 908 (Centaurea constits, activity) [https://doi.org/10.1016/S0031-9422(00)00254-5]
  40. Skaltsa, H. et al., Z. Naturforsch., C, 2000, 55, 534- 539 (Centaurea achaia constit) [https://doi.org/10.1515/znc-2000-7-810]
  41. Fortuna, A.M. et al., Biochem. Syst. Ecol., 2001, 29, 967- 971 (Centaurea tweediei ester) [https://doi.org/10.1016/S0305-1978(01)00042-4]
  42. Zidorn, C. et al., Z. Naturforsch., C, 2001, 56, 904- 908 (Leontodon cichoraceus constit)
  43. Saroglou, V. et al., J. Nat. Prod., 2005, 68, 1404- 1407 (Centaurea spinosa constits, activity) [https://doi.org/10.1021/np058042u]
  44. Marco, J.A. et al., Phytochemistry, 2005, 66, 1644- 1650 (Centaurea aspera constit) [https://doi.org/10.1016/j.phytochem.2005.06.004]
  45. Bach, S.M. et al., Nat. Prod. Commun., 2011, 6, 163- 166 (Cnicin, Onopordopicrin, activity)
  46. Ozawa, T., Yakugaku Zasshi, 1952, 72, 551- 553 (Arctigenin, synth, abs config) [https://doi.org/10.1248/yakushi1947.72.4_551]
  47. Hänsel, R. et al., Z. Naturforsch., B, 1964, 19, 727- 734 (Arctiin, occur) [https://doi.org/10.1515/znb-1964-0810]
  48. Nishibe, S. et al., Chem. Pharm. Bull., 1972, 20, 2710- 2719 (Arctiin, Arctigenin gentiobioside) [https://doi.org/10.1248/cpb.20.2075]
  49. Ingaki, I. et al., Chem. Pharm. Bull., 1973, 21, 2778- 2779 (Arctigenin gentiobioside, synth)
  50. Nishibe, S. et al., Experientia, 1973, 29, 17- 18 (Arctigenin gentiobioside)
  51. Omar, A.A., Lloydia, 1978, 41, 638- 639 (Arctiin)
  52. Suzuki, H. et al., Phytochemistry, 1982, 21, 1824- 1825 ((+)-Arctigenin) [https://doi.org/10.1016/S0031-9422(82)85082-6]
  53. Brown, E. et al., Tetrahedron, 1989, 45, 141- 154 (synth) [https://doi.org/10.1016/0040-4020(89)80041-9]
  54. Rahman, M.M.A. et al., Phytochemistry, 1990, 29, 1971- 1980 (Arctigenin, Arctiin) [https://doi.org/10.1016/0031-9422(90)85050-P]
  55. Eich, E. et al., Planta Med., 1990, 56, 506 (activity) [https://doi.org/10.1055/s-2006-961045]
  56. Imehara, K. et al., Chem. Pharm. Bull., 1993, 41, 1774- 1779 (Arctigenin, activity) [https://doi.org/10.1248/cpb.41.1774]
  57. Ozawa, S. et al., Phytochemistry, 1993, 32, 643- 652 (biosynth) [https://doi.org/10.1016/S0031-9422(00)95149-5]
  58. Mitra, J. et al., Indian J. Chem., Sect. B, 1994, 33, 953- 956 (synth)
  59. Hirano, T. et al., Life Sci., 1994, 55, 1061- 1069 (activity) [https://doi.org/10.1016/0024-3205(94)00641-5]
  60. Youssef, D. et al., Planta Med., 1995, 61, 570- 573 (pmr, cmr) [https://doi.org/10.1055/s-2006-959378]
  61. Eich, E. et al., J. Med. Chem., 1996, 39, 86- 89 (anti-HIV activity) [https://doi.org/10.1021/jm950387u]
  62. Sibi, M.P. et al., JOC, 2002, 67, 1738- 1745 (synth) [https://doi.org/10.1021/jo015501x]
  63. Fischer, J. et al., Org. Lett., 2004, 6, 1345- 1348 (synth) [https://doi.org/10.1021/ol049878b]
  64. Shoeb, M. et al., Phytochemistry, 2006, 67, 2370- 2375 (Americanin) [https://doi.org/10.1016/j.phytochem.2006.08.012]
  65. Gao, H. et al., Acta Cryst. E, 2008, 64, o1538 (cryst struct)
  66. Matsuzaki, Y. et al., Oncol. Rep., 2008, 19, 721- 727 (Arctiin, activity)
  67. Liu, Y.-D. et al., J. Asian Nat. Prod. Res., 2010, 12, 828- 833 (Acetylarctiins)
  68. Sun, C. et al., Chem. Nat. Compd. (Engl. Transl.), 2012, 48, 493- 497 (Wikstroemia indica constit)
  69. Chen, G-R. et al., Nat. Prod. Res., 2012, 26, 177- 181 (activity)
  70. Ifantis, T.M. et al., Phytochemistry, 2013, 94, 159- 170 (Centaurea pannonica constit) [https://doi.org/10.1016/j.phytochem.2013.05.014]
  71. Liu, F. et al., J. Sep. Sci., 2014, 37, 376- 381 (Arctigenin, isol, purifn)
  72. Yang, Y.-N. et al., J. Agric. Food Chem., 2015, 63, 7958- 7966 (Arctium lappa diglycosides) [https://doi.org/10.1021/acs.jafc.5b02838]
  73. Guan, Y.-X. et al., Zhongcaoyao, 2015, 46, 1620- 1624 (Arctigenin, prodn)
  74. Lü, H. et al., J. Chromatogr. Sci., 2016, 54, 472- 478 (Arctigenin, isol, purfn)
  75. Ping, W. et al., Youji Huaxue, 2016, 36, 1111- 1117 (Arctigenin, synth)
  76. Ichihara, A. et al., Tet. Lett., 1978, 19, 3035- 3038 (Lappaol F) [https://doi.org/10.1016/S0040-4039(01)94932-9]
  77. Ichihara, A. et al., Tet. Lett., 1979, 20, 3735- 3736 (Lappaol F, abs config) [https://doi.org/10.1016/S0040-4039(01)95511-X]
  78. Park, S.Y. et al., Chem. Pharm. Bull., 2007, 55, 150- 152 (Lappaol F, activity) [https://doi.org/10.1248/cpb.55.150]
  79. Sun, Q. et al., Mol. Cancer Ther., 2014, 13, 49- 59 (Lappaol F, activity) [https://doi.org/10.1158/1535-7163.MCT-13-0552]
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