Nutriceutical Formulation


Nutriceutical Formulation

Processing and isolation of bioactive food components, emulsions, and powders

Equipment for isolation of bioactive food components, production of delivery systems such as emulsions and powders and several food processing operations including concentration by reverse osmosis, ultrahigh and HTST pasteurization, spray drying. Instruments are available to characterize liquid and dried delivery systems and test their biological efficacy. Space is also available for standard food production operations.

Bioactives Isolation/Concentration:

  • Supercritical CO2 Extraction
  • Preparative HPLC with Mass Spectroscopy
  • Reverse Osmosis/Ultrafiltration Unit

Delivery System Production:

  • Ultrahigh/High Temperature, Short Time Pasteurization Unit
  • Agitating Retort
  • Freeze Dryer
  • Nano-crystallization unit (CR5 PureNano Microfluidizers)
  • Pilot Plant Spray Dryer and Agglomeration System

Delivery Systems Characterization:

  • Powder Laser Diffraction Unit
  • Gas sorption surface area analysis
  • Polymer characterization HPLC
  • Colonic fermenter

Equipment

Pilot Plant Agglomeration System

Pilot Plant Agglomeration System

This GEA system allows for spray drying and agglomeration to produce powders from food and bioactive delivery systems.

UHT/HTST Pasteurization Unit

UHT/HTST Pasteurization Unit

The Microthermics system allows for both High Temperature Short Time and UltraHigh Temperature pasteurization and aseptic filling.

Preparative HPLC with Mass Spectroscopy

Preparative HPLC with Mass Spectroscopy

The Shimadzu system can be used for preparative scale isolation and identification of bioactive using standard HPLC techniques.

Freeze Drying System

Freeze Drying System

A small scale lyophilization system for food grade components.

Laser Diffraction Particle Size Analyzer

Laser Diffraction Particle Size Analyzer

Conducts analysis of physical characteristics of powders.

Size Exclusion Chromatography

Size Exclusion Chromatography

HPLC technique to characterize biopolymers.

Nano Crystallization Units

Nano Crystallization Units

Homogenization technique that can be used to produce nanocrystals for food and pharma applications.

Colonic Fermenter

Colonic Fermenter

A model colonic microbial model system that can be used to test the metabolic fates of nutrients and pharmaceuticals.

Supercritical Fluid System

Supercritical Fluid System

A carbon dioxide method for the clean isolation of bioactive compounds from biological materials.

Gas Absorption Analyzer

Gas Absorption Analyzer

Fully automated, high vacuum, manometric gas sorption analyzer capable of analyzing surface area, pore size distribution, pore volume and isothermal heats of adsorption using a variety of coolants and adsorbates for a wide variety of sample types.

Reverse Osmosis Pilot Plant Ultrafiltration Unit

Reverse Osmosis Pilot Plant Ultrafiltration Unit

A technique for the removal of water and small molecular weight compounds from aqueous systems.

Agitating retort

Agitating retort

A pilot scale retort for sterilization of flexible pouches.

Constant Systems CF Range Cell Disruptor

Constant Systems CF Range Cell Disruptor

The CF cell disruptor in the core is a “French press” type system to lyse cells and extract expressed proteins. Once a sample is drawn into our high pressure cylinder, pressure is built until it reaches the value set by the user. Then a piston forces the sample through a fixed orifice at high velocity before it impacts on a cooled heat exchange surface, and then flows through an outlet for collection.

ÄKTA Flux 6

ÄKTA Flux 6

ÄKTA flux is a versatile cross flow filtration system for sample concentration and diafiltration as well as cell harvest and clarification.

  • Low working and hold-up volumes to support a wide range of concentration factors
  • Automated end-point control and data logging
  • Flexible handling of both hollow fiber cartridges and cassettes
  • Versatile design enables use in both ultra- and microfiltration applications
  • Easy-to-use operator interface

The ÄKTA flux system allows effortless filtrations using cassettes and hollow fiber filter cartridges. It is available in two versions: ÄKTA flux s for research and filter screenings, and ÄKTA flux 6 for process development and scale-up experiments.

The ÄKTA flux filtration system is well-suited for use in protein purification workflows as a complement to the ÄKTA chromatography systems.

Location

127 Chenoweth Laboratory
University of Massachusetts Amherst
100 Holdsworth Way
Amherst, MA 01003