hMRC Publications


2025

  1. Erol ME, Bannon ST, Matias AA, Siokas T, Nagarajan R, Fur YL, Park SY, Layec G. Mitochondrial efficiency in resting skeletal muscle in vivo: a novel non-invasive approach using multinuclear magnetic resonance spectroscopy in humans. J Physiol. 2025 Feb 17. doi: 10.1113/JP287412. Online ahead of print.(Link: https://pubmed.ncbi.nlm.nih.gov/39960635/)
  2. Nagarajan R and Sheehan MC. Comparative Study of PRESS, STEAM, sLASER, and LASER Techniques in Soleus Muscle Long Echo Time MRS at 3T. Abstract presented at the International Society for Magnetic Resonance in Medicine (Hawaii), Abstract, 4508, 2025. (Link: https://submissions.mirasmart.com/ISMRM2025/Itinerary/?Refresh=1&ses=D-133)
  3. Smith ZH, Fitzgerald LF, Nagarajan R, Hayes KL, Meyerspeer M, Lopez Kolkovsky AL, Kent JA. Does Lower Oxidative Capacity Influence the Relative Contributions of ATP-Producing Pathways During Muscular Work in Aging?. The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences. 2025 Jul 2:glaf142. (Link: https://pubmed.ncbi.nlm.nih.gov/40600907/) 
  4. Hayden CMT, Busa MA, Smith ZH, Nagarajan R, Arieta LR, Kent JA.Skeletal muscle energetics during submaximal contractions are linked to metabolic performance during ambulatory exercise: A pilot study in male adults. Physiol Rep. 2025 Aug;13(16):e70528. doi: 10.14814/phy2.70528.(Link: https://pubmed.ncbi.nlm.nih.gov/40859664/)

2024

  1. Matias AA, Serviente CF, Decker ST, Erol ME, Giuriato G, Le Fur Y, Nagarajan R, Bendahan D, Layec G. Repeatability of alkaline inorganic phosphate quantification in the skeletal muscle using 31P-magnetic resonance spectroscopy at 3T. NMR Biomed. 2024 Sep 3:e5255. 
    (Link: https://pubmed.ncbi.nlm.nih.gov/39225116/)
  2. Nikoumanesh N, Chase CJ, Nagarajan R, Potter K, Martini DN. Frontal cortex neurometabolites and mobility in older adults: a preliminary study. Experimental Brain Research. 2024 Jun 29:1-0.
    (Link: https://pubmed.ncbi.nlm.nih.gov/38949687/)
  3. Hayden CMT, Nagarajan R, Smith ZH, Gilmore S, Kent JA. Postcontraction [acetylcarnitine] reflects interindividual variation in skeletal muscle ATP production patterns in vivo. Am J Physiol Regul Integr Comp Physiol. 2024 Jan 1;326(1):R66-R78.
    (Link: https://pubmed.ncbi.nlm.nih.gov/37955131/)
  4. Bartlett MF, Fitzgerald LF, Nagarajan R, Kent JA. Measurements of in vivo skeletal muscle oxidative capacity are lower following sustained isometric compared with dynamic contractions. Appl Physiol Nutr Metab. 2024 Feb 1;49(2):250-264.
    (Link: https://pubmed.ncbi.nlm.nih.gov/37906958/)
  5. Sadil P, Cowell RA, Huber DE. The push–pull of serial dependence effects: Attraction to the prior response and repulsion from the prior stimulus. Psychonomic Bulletin & Review. 2024 Feb;31(1):259-73. (Link: https://pubmed.ncbi.nlm.nih.gov/37566217/)
  6. Erol ME, Bannon ST, Matias AA, Siokas T, Nagarajan R, Fur YL, Park SY, Layec G. Quantifying in vivo Mitochondrial Efficiency at Rest and during Exercise in Human Skeletal Muscle. Abstract P0771, American Physiology Summit  2024 (California, USA).
    (Link: https://events.rdmobile.com/Sessions/Details/2207981)
  7. Arieta LR, SMith ZH, Hayes KL, Nagarajan R, Lopez Kolkovsky AL, Meyerspeer M, Kent JA. Intramyocellular Oxygen Availability Does Not Limit Oxidative Capacity In Vivo In Young Or Older Adults.  Abstract 1363, American College of Sports Medicine 2024 (Boston, USA).
    (Link:  https://www.abstractsonline.com/pp8/#!/20101/presentation/4996)

2023

  1. Fitzgerald LF, Bartlett MF, Kent JA. Muscle fatigue, bioenergetic responses and metabolic economy during load‐and velocity‐based maximal dynamic contractions in young and older adults. Physiological Reports. 2023 Nov;11(22):e15876. (Link: https://pubmed.ncbi.nlm.nih.gov/37996974/)
  2. Nagarajan R, Saucedo A, Thomas MA. In vivo investigation of a Healthy Liver Lipid composition by 2D L-COSY Using 3T. Abstract presented at the International Society for Magnetic Resonance in Medicine (Toronto), Abstract, 2047, 2023.
    (Link: https://submissions.mirasmart.com/ISMRM2023/Itinerary/ConferenceMatrixEventDetail.aspx?ses=D-45)
  3. Nagarajan R, Kent JA, Layec G. Two Dimensional MRSI of Human Calf Muscle at 3T: Decoupling and NOE effects on PDE and total NAD. Abstract presented at the International Society for Magnetic Resonance in Medicine (Toronto), Abstract, 3951, 2023.
    (Link: https://submissions.mirasmart.com/ISMRM2023/Itinerary/ConferenceMatrixEventDetail.aspx?ses=D-22)
  4. Arieta LR, Smith ZH, Hayes KL, Nagarajan R, Meyerspeer M, Kent JA. Intracellular Oxygen Availability Does Not Limit Muscle Oxidative Capacity in Vivo in Untrained Young Adults. Abstract presented at the New England Chapter of the American College of Sports Medicine (NEACSM), Massachusetts, 2023.
    (Link: https://www.neacsm.org/fall2023)
  5. Ross DA, Shinde AB, Lerud KD, Schlaug G. Multielectrode Network Stimulation (ME-NETS) demonstrated by concurrent tDCS and fMRI. bioRxiv. 2023 Jun 14:2023-06.(Link: https://pubmed.ncbi.nlm.nih.gov/37398497/)
  6. Shinde A, Nagarajan R, Gunduz ME, Visintainer P, Schlaug G. Assessing the Dose-Dependent Effects of tDCS on Neurometabolites using Magnetic Resonance Spectroscopy. bioRxiv. 2023 Jun 14;. doi: 10.1101/2023.06.13.544864. PubMed PMID: 37398447.
    (Link: https://pubmed.ncbi.nlm.nih.gov/37398447/)
  7. Shinde A, Mohapatra S, Schlaug G. Identifying the engagement of a brain network during a targeted tDCS-fMRI experiment using a machine learning approach. PLOS Computational Biology. 2023 Apr 12;19(4):e1011012. (Link: https://pubmed.ncbi.nlm.nih.gov/37043484/)

2022

  1. Nagarajan R, Shinde A, Gunduz ME, Schlaug G. A concurrent tDCS-MEGA PRESS MRS study to investigate polarity dependent effects on neurometabolites. Abstract presented at the International Society for Magnetic Resonance in Medicine (London), Abstract, 2015, 2022 (Link: https://submissions.mirasmart.com/ISMRM2022/Itinerary/ConferenceMatrixEventDetail.aspx?ses=D-142)
  2. Nagarajan R, Hayden C, Gilmore S, Kent JA. Contraction-Induced Changes in Acetylcarnitine in the Human Vastus Lateralis Muscle Detected by 1HMRS at 3T. Abstract presented at the International Society for Magnetic Resonance in Medicine (London), Abstract, 1019,  2022 (Link: https://submissions.mirasmart.com/ISMRM2022/Itinerary/ConferenceMatrixEventDetail.aspx?id=133)
  3. Nagarajan R, Layec G, Kent JA. Intra-Subject Variability of Skeletal Muscle Glycogen Using C/H MRS at 3T Using a Novel Standardization Method. Abstract presented at the International Society for Magnetic Resonance in Medicine (London), Abstract, 1147,  2022 (Link: https://submissions.mirasmart.com/ISMRM2022/Itinerary/ConferenceMatrixEventDetail.aspx?id=504)
  4. Matias A, Decker S, Serviente CF, Erol ME, Giuriato G, Fur YL, Nagarajan R, Layec G. Reproducibility of Alkaline Inorganic Phosphate Quantification using 31P-Magnetic Resonance Spectroscopy at 3T . Abstract presented at the International Society for Magnetic Resonance in Medicine (London), Abstract, 3391,  2022 (Link: https://submissions.mirasmart.com/ISMRM2022/Itinerary/ConferenceMatrixEventDetail.aspx?ses=G-154)
  5. Gordon III JA, Remillard NM, Arieta A, Nagarajan R, Damon BM, Kent JA. Muscle Fat & Architecture Assessment by Diffusion Tensor Imaging on in vivo Muscle Function. Abstract presented at the International Society for Magnetic Resonance in Medicine (London), Abstract, 1130, 2022 (Link: https://submissions.mirasmart.com/ISMRM2022/Itinerary/ConferenceMatrixEventDetail.aspx?id=134)
  6. Joy A, Nagarajan R, Saucedo A, Iqbal Z, Sarma MK, Wilson NE, Felker E, Reiter RE, Raman SS and Thomas MA. Accelerated Echo Planar J-Resolved Spectroscopic Imaging in Prostate Cancer And A Hybrid Dictionary Learning-Total Variation Compressed Sensing Reconstruction. Abstract presented at the International Society for Magnetic Resonance in Medicine (London), Abstract, 3485, 2022 (Link: https://submissions.mirasmart.com/ISMRM2022/Itinerary/ConferenceMatrixEventDetail.aspx?ses=G-155)
  7. Hayes KL, Smith ZH, Hayden CMT, Nagarajan R, Alvarado F, Kent JA. Intracellular PO2 Does Not Limit Skeletal Muscle Bioenergetics During Fatiguing Contractions In Vivo. FASEB J,  13 May 2022. (Link: https://faseb.onlinelibrary.wiley.com/doi/10.1096/fasebj.2022.36.S1.0R778)
  8. Hayden C, Smith Z, Nagarajan R, Gilmore SI, Kent JA. Accumulation of Intramyocellular Acetylcarnitine is Associated with Glycolytic ATP Production In Vivo During Incremental Contractions in Human Skeletal Muscle. FASEB J,  13 May 2022. (Link: https://faseb.onlinelibrary.wiley.com/doi/10.1096/fasebj.2022.36.S1.R3922)
  9. Gordon III JA, Remillard NM, Woods PC, Arieta LR, Momb BA, Chipkin SR, Nagarajan R, Damon BM, Miller MS, Kent JA. Molecular Basis for Greater in Vivo Skeletal Muscle Specific Torque in Males Compared to Females. Abstract 2096, ACSM 2022 (California). (Link: https://www.abstractsonline.com/pp8/#!/10504/presentation/1964)
  10. Hayden CM, Gilmore S, Copeland J, Smith ZH, Nagarajan R, Busa M, Kent JA. In vivo Muscle Bioenergetics Predict Whole-Body Metabolic Responses During a 30-Minute Treadmill Walk. Abstract 1599, ACSM 2022 (California). (Link: https://www.abstractsonline.com/pp8/#!/10504/presentation/1978)
  11. Hayes KL, Smith ZH, Hayden CM, Nagarajan R, Alvarado F, Kent JA. Recovery of Glucose-6-Phosphate but not ATP Following Fatiguing Skeletal Muscle Contractions in Humans. Abstract 1626, ACSM 2022 (California).  (Link: https://www.abstractsonline.com/pp8/#!/10504/presentation/2038)
  12. Joy A, Nagarajan R, Saucedo A, et al. Dictionary learning compressed sensing reconstruction: pilot validation of accelerated echo planar J-resolved spectroscopic imaging in prostate cancer. MAGMA. 2022 Jul 23:1-16. doi: 10.1007/s10334-022-01029-z. Link: https://pubmed.ncbi.nlm.nih.gov/35869359/
  13. Joy A, Nagarajan R, Daar ES, et al. Alterations of gray and white matter volumes and cortical thickness in treated HIV-positive patients. Magn Reson Imaging. 2022 Oct 17:S0730-725X(22)00176-X. doi: 10.1016/j.mri.2022.10.006.(Link: https://pubmed.ncbi.nlm.nih.gov/36265696/)

2021

  1. Zaleznik E, Park J. The neural basis of counting sequences. Neuroimage. 2021 Aug 15;237:118146. (link: https://pubmed.ncbi.nlm.nih.gov/33965527/)
  2. Bartlett MF, Fitzgerald LF, Kent JA. Rates of oxidative ATP synthesis are not augmented beyond the pH threshold in human vastus lateralis muscles during a stepwise contraction protocol. The Journal of physiology. 2021 Apr;599(7):1997-2013. (Link: https://pubmed.ncbi.nlm.nih.gov/33576028/)
  3. Fitzroy AB, Kainec KA, Spencer RM. Ageing‐related changes in nap neuroscillatory activity are mediated and moderated by grey matter volume. European Journal of Neuroscience. 2021 Nov;54(9):7332-54. (Link: https://pubmed.ncbi.nlm.nih.gov/34541728/)
  4. Fitzroy AB, Jones BJ, Kainec KA, Seo J, Spencer RM. Aging-related changes in cortical sources of sleep oscillatory neural activity following motor learning reflect contributions of cortical thickness and pre-sleep functional activity. Frontiers in Aging Neuroscience. 2022 Jan 11;13:787654. (Link: https://pubmed.ncbi.nlm.nih.gov/35087393/)
  5. Fitzroy AB, Kainec KA, Seo J, Spencer RM. Encoding and consolidation of motor sequence learning in young and older adults. Neurobiology of Learning and Memory. 2021 Nov 1;185:107508. (Link: https://pubmed.ncbi.nlm.nih.gov/34450244/)
  6. Fitzgerald LF, Bartlett MF, Nagarajan R, Francisco EJ, Iv FC, Kent JA. Effects of Old age and contraction mode on knee extensor muscle ATP flux and metabolic economy in vivo. J Physiol. 2021 Apr 19. doi: 10.1113/JP281117.  [  Link: https://pubmed.ncbi.nlm.nih.gov/33876434/ ]
  7. Nagarajan R, Shinde A, Gunduz ME, Schlaug G. Polarity Dependent Modulation of the Motor Region Using tDCS: A Proton MR Spectroscopy Study. Abstract accepted at the International Society for Magnetic Resonance in Medicine, Abstract, 2234, 2021. (Online)  [  Link: https://www.ismrm.org/21/program-files/D-130.htm ]
  8. Nagarajan R, Layec G. Feasibility Study of 31P Multivoxel Spectroscopy for the detection of Alkaline Inorganic Phosphate in multiple compartments of the lower leg at 3T. Abstract accepted at the International Society for Magnetic Resonance in Medicine, Abstract, 3179, 2021. (Online)  [  Link: https://www.ismrm.org/21/program-files/D-50.htm ]
  9. Han S, Currier T, Edraki M, Liu B, Lynch ME, Modarres-Sadeghi Y. Flow inside a bone scaffold: Visualization using 3D phase contrast MRI and comparison with numerical simulations. Journal of Biomechanics. 2021 Sep 20;126:110625. (Link: https://pubmed.ncbi.nlm.nih.gov/34293601/)

2020

  1. Fitzgerald LF, Martin A, Nagarajan R, Kent JA. Torque and Velocity Dependence of Muscle Fatigue in Aging. Innov Aging. 2020; 4(Suppl 1): 491–492. Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743394/
  2. Gordon JA. III, Remillard NM, Straight CR, Nagarajan R, Damon BM, Chipkin SR, Miller MS, Kent, JA. Age-Related Changes in Molecular and Whole Muscle Function: Role of Fat Content?. Innov Aging. 2020; 4(Suppl 1): 141. Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7740761/
  3. Iqbal Z, Nagarajan R, Sarma M, et al. Evaluating Apparent T2* values of Metabolites in Healthy Adults and Youths using TIDEL-COSY. Abstract presented at the International Society for Magnetic Resonance in Medicine, Abstract, 6738, 2020. Link: https://www.ismrm.org/20/program_files/DP06-01.htm
  4. Fitzgerald LF, Bartlett MF, Martin AR, Francisco E, Sup F, Nagarajan R, Kent JA. Effects Of Old Age And Contraction Mode On Knee Extensor Muscle Metabolic Economy In Vivo. Medicine & Science in Sports & Exercise 52 (7).
  5. Jaber Y, Jimenez Francisco E, Bartlett MF, Fitzgerald LF, Kent JA, Sup IV FC. Magnetic resonance compatible knee extension ergometer. Journal of Biomechanical Engineering. 2020 Sep 1;142(9):095001.(Link: https://pubmed.ncbi.nlm.nih.gov/32140702/)
  6. Bartlett MF, Fitzgerald LF, Nagarajan R, Kent JA. Validity and accuracy of calculating oxidative ATP synthesis in vivo during high-intensity skeletal muscle contractions. NMR Biomed. 2020 Aug 16;e4381. Link: https://pubmed.ncbi.nlm.nih.gov/32803787/ GSAAnnual
  7. Smithline H, Bartlett, Kent JA, Yadava N, Nagarajan R. Pilot Investigation of Effects of Nicotinamide Riboside Supplementation on Nicotinamide Adenine Dinucleotide Concentration in Human Skeletal Muscle Using 31P MR Spectroscopy. Abstract presented at the Experimental NMR Conference (Baltimore, USA) Abstract, 192, 2020.
  8. Nagarajan R, Ramadan S, Decker S, Layec G. Optimization of Proton MRS of Deoxymyoglobin in Human Skeletal Muscle at 3T: a tool for measuring Intracellular O2 availability. Abstract presented at the Experimental NMR Conference (Baltimore, USA) Abstract, 267, 2020.
  9. Nagarajan R, Saucedo A, Sarma MK, Andrews P, Kent JA, Thomas MA. Detection of Residual Dipolar Coupling in Vastus Lateralis by Two-dimensional Localized Correlated Spectroscopy. Abstract presented at the Experimental NMR Conference (Baltimore, USA) Abstract, 201, 2020.
  10. Bartlett MF, Fitzgerald LF, Nagarajan R, Hiroi Y, Kent JA. Oxidative ATP Synthesis in Human Quadriceps Declines During 4 Minutes of Maximal Contractions. J Physiol. 2020 Feb 11. doi: 10.1113/JP279339.
  11. Iqbal Z, Nagarajan R, Saucedo A, Sarma MK, Thomas MA. Measuring T2 * values of Metabolites In Vivo utilizing T2 *- Weighted Deconvolution Localized Correlated Spectroscopy (TIDEL-COSY). Abstract presented at the Experimental NMR Conference (Baltimore, USA) Abstract, 80, 2020.

2019

  1. Gholizadeh N, Pundavela J, Nagarajan R, Dona A, Quadrelli S, Biswas T, Greer PB, Ramadan S. Nuclear magnetic resonance spectroscopy of human body fluids and in vivo magnetic resonance spectroscopy: Potential role in the diagnosis and management of prostate cancer. Urol Oncol. 2020 Jan 11. pii: S1078-1439(19)30443-0. doi: 10.1016/j.urolonc.2019.10.019. [Epub ahead of print]
  2. Saucedo A, Sarma M, Darwin C, Kumar S, Umachandran K, Nagarajan R, Thomas MA. Accelerated Five-Dimensional Echo-Planar Correlated Spectroscopic Imaging to assess Lipids and Metabolite differences between Type-2 Diabetic and Healthy Calf Muscle. Abstract presented at the International Society for Magnetic Resonance in Medicine (Montreal, Canada) Abstract, 2539, 2019. Link: Read the PDF.
  3. Gordon III JA, Nagarajan, R, Miller MS, Damon B, Kent JA. Amount of Variability of Adipose Tissue Content in Human Quadriceps Muscles of Older Adults. Abstract presented at ACSM meeting (Florida, USA), Abstract, 302, 2019.

2018

  1. Bartlett MF, Fitzgerald LF, Nagarajan R, Kent JA . Limitations to Oxidative ATP Synthesis During High-Intensity Contractions: A Hyperoxic Mitochondrial Uncoupling Hypothesis. Abstract presented at the ACSM Integrative Physiology of Exercise Conference ( San Diego, California, USA) Abstract 168, 2018.
  2. Fitzgerald LF, Bartlett MF, Nagarajan R, Kent JA. In Vivo Muscle Oxidative Capacity Differs with Contraction Mode and Energetic Demand. Abstract presented at the ACSM Integrative Physiology of Exercise Conference ( San Diego, California, USA) Abstract 237, 2018.
  3. Gordon III JA, Nagarajan R, Arieta LR, Bartlett MF, Fitzgerald LF, Damon BM, Kent JA. Variability of Fat Deposition in Human Quadriceps Muscle in Vivo. Abstract presented at the ACSM Integrative Physiology of Exercise Conference ( San Diego, California, USA) Abstract 273, 2018.
  4. Rajakumar Nagarajan, Miles Bartlett, Kwan-Jin Jung, Jane A. Kent, and Nagendra Yadava. Human Magnetic Resonance Center, Institute for Applied Life Sciences, University of Massachusetts, Amherst, MA, United States; Department of Kinesiology, UMass, Amherst, MA, United States, Department of Biology, UMass, Amherst, MA; Pioneer Valley Life Sciences Institute (PVLSI), Springfield, MA; Department of Medicine, University of Massachusetts Medical School (UMMS)-Baystate Regional Campus, Springfield, MA. Non-invasive Detection of NADH+NAD+ in Human Muscle Using 31P MR Spectroscopy at 3T. Abstract presented at the International Society for Magnetic Resonance in Medicine (Paris, France) Abstract 5129, 2018.
  5. Kwan-Jin Jung and Jacquie Kurland, Human Magnetic Resonance Center, University of Massachusetts Amherst, Amherst, MA, United States; Department of Communication Disorders, University of Massachusetts Amherst. Diaschisis of The Language Network in Resting State fMRI Functional Connectivity of Post-Stroke Chronic Aphasia. Abstract presented at the International Society for Magnetic Resonance in Medicine (Paris, France), 2018.
  6. Kwan-Jin Jung and Hae-Min Jung, Human Magnetic Resonance Center, Institute of Applied Life Sciences, University of Massachusetts Amherst, Amherst, MA, Austen Riggs Center, Stockbridge, MA. A Weighted Square Averaging Method of Combining Primary and Temporal Derivative Parameter Estimates In General Linear Model Analysis of Functional MRI. Abstract presented at the International Society for Magnetic Resonance in Medicine (Paris, France), 2018.
  7. Kwan-Jin Jung, Youssef Jaber, and Frank C Sup IV, Human Magnetic Resonance Center, Institute of Applied Life Sciences; Department of Mechanical and Industrial Engineering, University of Massachusetts Amherst. A Validation of MR Flow Velocity Mapping with Automated Phase Offset Correction Using a Gel Flow Phantom Controlled by a Motorized Piston in MR Phase Contrast Cine Flow Measurement. Abstract presented at the International Society for Magnetic Resonance in Medicine (Paris, France) 2018.

2017

  1. Bartlett M, Nagarajan R, Fitzgerald L, Chow E, Kent J. Calculating Muscle Oxidative ATP Synthesis in Vivo during High Intensity Contractions Using 31-Phosphorous Magnetic Resonance Spectroscopy: Adjusting for Changes in Vmax. Abstract presented at the Physiological Bioenergetics: Mitochondria from Bench to Bedside (APS Conference) (California, USA) Abstract, 9.1, 2017.
  2. Bartlett M, Nagarajan R, Fitzgerald L, Jaber Y, Chow E, Miehm J, Kent J. In Vivo Skeletal Muscle Energetics and Fatigue Are Not Different in Men and Women during Incremental Dynamic Knee Extension Work. Abstract presented at the Physiological Bioenergetics: Mitochondria from Bench to Bedside (APS Conference) (California, USA) Abstract, 9.16, 2017.
  3. Nagarajan R, Jaber Y, Barlette M, Fitzgerald L, Miehm J, Sup FC 4th, Kent JA. Development of an MR-Compatible Ergometer for Use in Quantifying Human Skeletal Muscle Bioenergetics During Supine Dynamic Contractions of the Knee Extensors. Abstract presented at the International Society for Magnetic Resonance in Medicine (Hawaii, USA) Abstract, 5001, 2017. Link: https://archive.ismrm.org/2017/5001.html