The University of Massachusetts Amherst

Models to Medicine Center

The Models to Medicine Center (M2M) aims to translate fundamental science into new targets, leads, and disease models. Faculty within the center leverage mechanistic insights into molecular pathways implicated in cell health and in disease pathology to identify novel drug targets and therapeutic candidates.

This facility conducts research using equipment capable of fluorescence and luminescence imaging independent of or concurrent with CT imaging.

Provides transgenic, gene targeting, and other services to the research community

Discovery-Based Research and Assay Development for Translational Applications

State-of-the-art facilities for fermentation and separation/purification of biomolecules.

Two cell culture facilities for both biological and bio-engineering approaches. Biosafety cabinets, incubators and general wet lab supplies.

Cell Culture

Provides consultative and collaborative service in computational and molecular modeling.

Transmission (TEM) and Scanning (SEM) Electron Microscopes as well as related sample preparation equipment.

Enables researchers to image structures ranging from single molecules to whole model organisms and performs microscope-based high-throughput screens.

Flow Cytometry

Provides solutions for Next-Generation Sequencing (NGS) and advances instrumentation for DNA, RNA analysis. Facility is equipped with instruments including Illumina NextSeq 500 and MiSeq.

Nine different Nikon microscopes available that enable a full range of light microscopy methods and applications. Expert support offered for acquisition and analysis of data.

Expertise measuring molecular weights of small molecules, biological and synthetic macromolecules, qualitative and quantitative proteomics, protein dynamics.

Mass Spectrometry
Solid and Liquid State NMR

Elucidates structure, conformation, dynamics and interactions between the molecules