Guodong Zhang
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Research:
Our research focuses on prevention of colonic inflammation (inflammatory bowel disease) and colon cancer. To achieve this, we address two major issues: (1) identification and characterization of novel environmental risk factors of IBD and colon cancer. We study how environmental and dietary compounds alter gut microbiome and deregulate mucosa immune system to exaggerate colonic inflammation and colon tumorigenesis; and (2) discovery of novel therapeutic targets and biomarkers of IBD and colon cancer. We use LC-MS/MS-based lipidomics and transgenic animal models to study the roles of eicosanoid signaling in colonic inflammation and colon cancer, in order to identify novel therapeutic targets and biomarkers of these diseases.
Teaching:
FS 797R: Research Methods
FS 581: Food Analysis
FS 583: Food Analysis Laboratory
Publications:
1. Wang W., Yang J., Edin M.L., Wang Y., Luo Y., Wan D., Yang H., Sanidad K.Z., Song M., Bisbee A.H., Bradbury J.A., Nan G., Zhang J., Shih B., Lee K., Minter L.M., Kim D., Xiao H., Liu J., Hammock B.D., Zeldin D.C., and Zhang G. (2019) Targeted metabolomics identifies cytochrome P450 monooxygenase eicosanoid pathway as novel therapeutic target of colon tumorigenesis. Cancer Research, in press.
2. Wang Y., Wang W., Yang H., Shao D., Zhao X., and Zhang G. (2019) Intraperitoneal injection of 4-hydroxynonenal (4-HNE), a lipid peroxidation product, exacerbates colonic inflammation through activation of Toll-like receptor 4 signaling. Free Radical Biology & Medicine, 131:237-242.
3. Yang H., Wang W., Romano K.A., Gu M., Sanidad K., Kim D., Yang J., Schmidt B., Panigrahy D., Pei R., Martin D.A., Ozay E.I., Wang Y., Song M., Bolling B.W., Xiao H., Minter L.M., Yang G., Liu Z., Rey F.E., and Zhang G. (2018) A common antimicrobial additive increases colonic inflammation and colon tumorigenesis in mice. Science Translational Medicine 10:eaan4116. Doi: 10.1126/scitranslmed.aan4116.
4. Wang W., Yang J., Zhang J., Wang Y., Hwang S., Qi W., Wan D., Kim D., Sun J., Sanidad K.Z., Yang H., Park Y., Liu J., Liu Z., Hammock B.D. and Zhang G. (2018) Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation. Proceedings of the National Academy of Sciences 115:5283-5288.
5. Sanidad K., Yang H., Wang W., Ozay E., Yang J., Gu M., Karner M., Zhang J., Kim D., Minter L., Xiao H., and Zhang G. (2018) Effects of consumer antimicrobials benzalkonium chloride, benzethonium chloride, and chloroxylenol on colonic inflammation and colitis-associated colon tumorigenesis in mice. Toxicological Sciences 163:490–499.
6. Wang W., Yang J., Nimiya Y., Lee K., Sanidad K., Qi W., Sukamtoh E., Park Y., Liu, Z., and Zhang G. (2017) ω-3 polyunsaturated fatty acids and their cytochrome P450-derived metabolites suppress colorectal tumor development in mice. Journal of Nutritional Biochemistry 48:29-35.
7. Wang W., Yang J., Qi W., Yang H., Wang C., Tan B., Hammock B.D., Park Y., Kim D., and Zhang G. (2017) Lipidomic profiling of high-fat diet-induced obesity in mice: importance of cytochrome P450-derived fatty acid epoxides. Obesity, 25, 132-140.
8. Wang W., Yang H., Johnson D., Gensler C., Decker E., and Zhang G. (2017) Chemistry and biology of ω-3 PUFA peroxidation-derived compounds. Prostaglandins & Other Lipid Mediators 132: 84-91.
9. Wang W., Yang J., Yang H., Sanidad K., Hammock B.D., Kim D., and Zhang G. (2016) Effects of high-fat diet on plasma profiles of eicosanoid metabolites in mice. Prostaglandins & Other Lipid Mediators 127:9-13.
10. Nimiya Y., Wang W., Du Z., Sukamtoh E., Zhu J., Decker E. and Zhang G. (2016) Redox modulation of curcumin stability: redox active antioxidants increase chemical stability of curcumin. Molecular Nutrition & Food Research 60:487-94.
11. Wang W., Du Z., Nimiya Y., Sukamtoh E., Kim D. and Zhang G. (2015) Allicin inhibits lymphangiogenesis through suppressing activation of vascular endothelial growth factor (VEGF) receptor. Journal of Nutritional Biochemistry 29:83-9.
12. Wang W., Sukamtoh E., Xiao H. and Zhang G. (2015) Curcumin inhibits lymphangiogenesis in vitro and in vivo. Molecular Nutrition & Food Research 59:2345-54.
13. Zhang G., Panigrahy D., HwangS., YangJ., MahakianL., WetterstenH., Liu J., Wang Y., InghamE., Tam S., Kieran M., WeissR.H., Ferrara K.W. and Hammock B.D. (2014) Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis. Proceedings of the National Academy of Sciences 111: 11127–11132.
14. Zhang G., Panigrahy D., MahakianL., YangJ., LiuJ., LeeK., WetterstenH., Ulu A., HuX., TamS., HwangS., InghamE., Kieran M., Weiss R.H., FerraraK.W. and Hammock B.D. (2013) Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth and metastasis. Proceedings of the National Academy of Sciences 110: 6530-5.