Lili He | Department of Food Science

Professor, Graduate Program Director

Field of Study:

Analytical chemistry, Raman spectroscopy, SERS, Nanofabrication, Infrared spectroscopy, X-ray fluorescent spectroscopy, Rapid detection, Characterization, Chemical Imaging

Office:

344 Chenoweth Laboratory

Telephone:

(413) 545-5847

Email:

lilihe@foodsci.umass.edu

Group Site:

http://people.umass.edu/lilihe/

Lili He is a Professor of Food Science at the University of Massachusetts, Amherst. She earned her Bachelor's and Master's degrees from Zhejiang University in China and obtained her PhD from the University of Missouri-Columbia in the United States in 2009. After completing her postdoctoral training at the University of Minnesota, she joined the Food Science Department at the University of Massachusetts, Amherst as an Assistant Professor in 2012. In 2018, Dr. He was promoted to Associate Professor, and in 2022, she was promoted to Full Professor. In 2020, Dr. He established the Raman, IR, and XRF Core Facility at the University of Massachusetts, providing analytical services to both the university and external clients.

Details

Research

Dr. Lili He's research focuses on the development and application of cutting-edge analytical techniques in the field of environmental, agricultural, and food sciences. A particular emphasis of her research is surface-enhanced Raman spectroscopy (SERS), an innovative and versatile molecular spectroscopy with ultra-sensitivity. In addition, she has also been working with surface-enhanced infrared absorption spectroscopy (SEIRAS) and X-ray fluorescent spectroscopy (XRF) to further advance her research. Dr. He has developed advanced methods for analyzing chemical, biological, and physical agents in complex systems, filling important gaps in our understanding of the prevalence, behavior, and biological fate of these analytes in environmental, agricultural, and food systems.

Teaching

FOOD-SCI 542 Food Chemistry II (2014-, every fall)

This food chemistry II course focuses on the fundamental chemistry of minor components, food additives (preservatives, colorants, flavors, emulsifiers, thickening and gelling agents, flour treatment agents), food processing aids, chemical toxins, and adulterants. The industrial applications of food additives and the governmental regulations on the chemical toxins and adulterants are also discussed. The learning objectives of this course are:

Develop an understanding of the fundamental chemistry of food minor components (e.g. minerals, vitamins, nutraceuticals), direct food additives (e.g. colors, flavors, preservatives, texture modifiers & stabilizers), incidental food additives (e.g. processing aids, chemical toxins), intentional adulterants, allergens, etc.
Develop an understanding of how key functional attributes of minor food components and direct and incidental food additives contribute to the overall quality attributes such as nutrition, flavor, texture, stability, and appearance and safety attributes.
Be able to utilize knowledge of food chemistry to improve the quality, diversity, convenience, safety, and healthfulness of the food supply.

FS781- Advanced food analysis (2022-,every other spring)

This course includes lectures of fundamental and application of Raman, Infrared and X-ray Fluorescence Spectroscopy (XRF) in food, agricultural and environmental analysis. It also offers hands-on training of these techniques, supported by the Raman, IR and XRF core facility. Industrial case studies of applications of these techniques to solve the real-world problems will be introduced. The learning objectives of this course are:

To develop a deep understanding of the fundamentals of Raman, Infrared and XRF Spectroscopy, and their applications in food, agricultural and environmental analysis.
To develop hand-on skills to operate the Raman, Infrared and XRF instruments to conduct basic analysis.
To be able to utilize knowledge and skills of Raman, Infrared and XRF techniques to advance the students’ own thesis and dissertation research project.

Awards

2022 UMass Family Research Scholar Award
2021 UMass Distinguished Graduate Mentor Award
2019 Top 5% highly cited author in Royal Society of Chemistry’s analytical portfolio of journals
2018-2019 Top downloaded paper in Journal of Raman Spectroscopy
Most-cited paper of 2016 Journal of Food Science (Toxicology and chemical food safety section)
Most-cited paper of 2014 Journal of Food Science (Toxicology and chemical food safety section)
2017 UMass Faculty Convocation Award
2016 Talented 12 by C&EN, the official magazine of American Chemical Society
2016 Samuel Cate Prescott Award by Institute of Food Technologists
2016 Young Investigator Award by Eastern Analytical Symposium
2015 Young Scientist Award by American Chemical Society-Agricultural and Food Chemistry Division
2015 UMass Faculty Exceptional Merit Award
2012 Young Scientist Award by International Union of Food Science and Technology
Top ten articles in Analyst July 2011
Most-cited paper of 2008 Journal of Food Science (Toxicology and chemical food safety section)

Publications

Wang, D., Du, X., & He, L. (2022). Investigation of the Impact of a Pesticide Adjuvant on Dimethoate Persistence, Penetration, and Stability on Apples Using Surface-Enhanced Raman Spectroscopy. ACS Agricultural Science & Technology. https://doi.org/10.1021/acsagscitech.2c00092
Gukowsky, J. C., & He, L. (2022). Development of a portable SERS method for testing the antibiotic sensitivity of foodborne bacteria. Journal of Microbiological Methods, 106496.
Guo, X., Lin, H., Xu, S., & He, L. (2022). Recent Advances in Spectroscopic Techniques for the Analysis of Microplastics in Food. Journal of Agricultural and Food Chemistry, 70(5), 1410-1422.
Wang, D., Yang, J., Pandya, J., Clark, J. M., Harrington, L. C., Murdock, C. C., & He, L. (2022). Quantitative age grading of mosquitoes using surface‐enhanced Raman spectroscopy. Analytical Science Advances, 3(1-2), 47-53.
Gukowsky, J. C., Yang, T., & He, L. (2022). Assessment of three SERS approaches for studying E. Coli O157: H7 susceptibility to ampicillin. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 264, 120239.
Shen, Y., Borgatta, J., Ma, C., Singh, G., Tamez, C., Schultes, N.P., Zhang, Z., Dhankher, O.P., Elmer, W.H., He, L. and Hamers, R.J., (2022). Role of Foliar Biointerface Properties and Nanomaterial Chemistry in Controlling Cu Transfer into Wild-Type and Mutant Arabidopsis thaliana Leaf Tissue. Journal of Agricultural and Food Chemistry, 70(14), 4267-4278.
Zhou, H.; Zheng, B.; Zhang, Z.; Zhang, R.; He, L.; McClements, D. J., Fortification of Plant-Based Milk with Calcium May Reduce Vitamin D Bioaccessibility: An In Vitro Digestion Study. Journal of agricultural and food chemistry 2021. 69, 4223.
Zhang, Z.; Lin, H.; Ma, C.; Zhang, L.; Zelevinsky, J.; Xia, M.; Xu, Y.; White, J. C.; Tyson, J.; He, L., Integrating the Gutzeit method with X-Ray fluorescence spectroscopy for rapid quantification of inorganic arsenic in selected beverages. Food Control 2021, 121, 107588.
Zhang, Z., Shang, H., Xing, B., & He, L. (2021). In-situ and Real Time Investigation of Foliarly Applied Silver Nanoparticles on and in Spinach Leaves by Surface Enhanced Raman Spectroscopic Mapping. Analytical Methods, https://doi.org/10.1039/D1AY00346A.
Wang, P.; Sun, Y.; Li, X.; Wang, L.; Xu, Y.; He, L.; Li, G., Recent Advances in Dual Recognition Based Surface Enhanced Raman Scattering for Pathogenic Bacteria Detection: A Review. Analytica Chimica Acta 2021, 338279.
Rojas, L. M.; Qu, Y.; He, L., A facile solvent extraction method facilitating surface-enhanced Raman spectroscopic detection of ochratoxin A in wine and wheat. Talanta 2021, 224, 121792.
Pandya, J. K.; Dai, H.; He, L., An innovative filtration based Raman mapping technique for the size characterization of anatase titanium dioxide nanoparticles. Talanta 2021, 224, 121836.
Pandya, J.K., Zhang, Z. and He, L., 2021. Surface‐Enhanced Raman Spectroscopic Analysis of Anatase Titanium Dioxide Nanoparticles: Investigation of the Key Factors. ChemistrySelect, 6(24), pp.5987-5993.
Chuesiang, P., Ryu, V., Siripatrawan, U., He, L. and McLandsborough, L., 2021. Aptamer-based surface enhanced Raman spectroscopy (SERS) for the rapid detection of Salmonella Enteritidis contaminated in ground beef. LWT, p.111937.
Chuesiang, P., Ryu, V., Siripatrawan, U., McLandsborough, L. and He, L., 2021. Investigation of factors that impact the label-free surface-enhanced Raman scattering (SERS) for the detection and discrimination of Salmonella Enteritidis. LWT, p.111962.
Lin, Z.; Gao, S.; Yang, J. S.; Qu, Y.; Zhang, Z.; He, L., A filtration-assisted approach to enhance optical detection of analytes and its application in food matrices. Food chemistry 2021, 338, 127814.
Li, Y.; Zhao, C.; Lu, C.; Zhou, S.; Tian, G.; He, L.; Bao, Y.; Fauconnier, M.-L.; Xiao, H.; Zheng, J., Simultaneous determination of 14 bioactive citrus flavonoids using thin-layer chromatography combined with surface enhanced Raman spectroscopy. Food chemistry 2021, 338, 128115.
Hickey, M. E.; He, L., SERS imaging analyses of bacteria cells among plant tissues. Talanta 2021, 225, 122008.
Guo, H.; Han, F.; Shang, H.; Xiong, S.; Huynh, M.; Thistle, L.; Meng, L.; He, L.; Xing, B., New insight into naturally formed nanosilver particles: role of plant root exudates. Environmental Science: Nano 2021. https://doi.org/10.1039/D0EN01188F
Du, X.; Chen, H.; Zhang, Z.; Qu, Y.; He, L., Headspace analysis of shelf life of postharvest arugula leaves using a SERS-active fiber. Postharvest Biology and Technology 2021, 175, 111410.
Zhao, B.; Yang, T.; Qu, Y.; Mills, A. J.; Zhang, G.; He, L., Rapid capture and SERS detection of triclosan using a silver nanoparticle core–protein satellite substrate. Science of The Total Environment 2020, 716, 137097.
Zhang, Z.; Xia, M.; Ma, C.; Guo, H.; Wu, W.; White, J. C.; Xing, B.; He, L., Rapid organic solvent extraction coupled with surface enhanced Raman spectroscopic mapping for ultrasensitive quantification of foliarly applied silver nanoparticles in plant leaves. Environmental Science: Nano 2020, 7, (4), 1061-1067.
Zhang, Y.; Gao, W.; Cui, C.; Zhang, Z.; He, L.; Zheng, J.; Hou, R., Development of a method to evaluate the tenderness of fresh tea leaves based on rapid, in-situ Raman spectroscopy scanning for carotenoids. Food chemistry 2020, 308, 125648.
Zhang, Q.; Guo, W.; He, L.; He, L.; Chen, Y.; Shen, X.; Wu, D., A new SERS substrate of self-assembled monolayer film of gold nanoparticles on silicon wafer for the rapid detection of polycyclic aromatic hydrocarbons. Materials Chemistry and Physics 2020, 250, 122994.
Wang, P.; Wang, X.; Sun, Y.; Gong, G.; Fan, M.; He, L., Rapid identification and quantification of the antibiotic susceptibility of lactic acid bacteria using surface enhanced Raman spectroscopy. Analytical Methods 2020, 12, (3), 376-382.
Vu, T. P.; He, L.; McClements, D. J.; Decker, E. A., Effects of water activity, sugars, and proteins on lipid oxidative stability of low moisture model crackers. Food Research International 2020, 130, 108844.
Tu, Q.; Lin, Z.; Liu, J.; Dai, H.; Yang, T.; Wang, J.; Decker, E.; McClements, D. J.; He, L., Multi-phase detection of antioxidants using surface-enhanced Raman spectroscopy with a gold nanoparticle-coated fiber. Talanta 2020, 206, 120197.
Qu, Y.; Wang, M.; Huang, S.; Decker, E. A.; McClements, D. J.; He, L., Headspace Characterization and Quantification of Aromatic Organosulfur Compounds in Garlic Extracts Using Surface-Enhanced Raman Scattering with a Mirror-in-a-Cap Substrate. Journal of AOAC International 2020, 103, (5), 1201-1207.
Qu, Y.; Tian, Y.; Chen, Y.; He, L., Chemical profiling of red wines using surface-enhanced Raman spectroscopy (SERS). Analytical Methods 2020, 12, (10), 1324-1332.
Qu, Y.; He, L., Development of a facile rolling method to amplify an analyte's weak SERS activity and its application for chlordane detection. Analytical Methods 2020, 12, (4), 433-439.
Ozel, B.; Zhang, Z.; He, L.; McClements, D. J., Digestion of animal-and plant-based proteins encapsulated in κ-carrageenan/protein beads under simulated gastrointestinal conditions. Food Research International 2020, 137, 109662.
Martinez, L.; He, L., Detection of Mycotoxins in Food Using Surface-Enhanced Raman Spectroscopy: A Review. ACS Applied Bio Materials 2020.
Hickey, M. E.; He, L., Understanding and Advancing the 3-mercaptophenylboronic Acid Chemical Label for Optimal Surface-enhanced Raman Spectroscopic Analysis of Bacteria Populations. ACS Applied Bio Materials 2020, 3, (12), 8768-8775.
Hickey, M. E.; Gao, S.; He, L., Comparison of label‐free and label‐based approaches for surface‐enhanced Raman microscopic imaging of bacteria cells. Analytical Science Advances 2020.
Gao, W.; Guo, J.; Xie, L.; Peng, C.; He, L.; Wan, X.; Hou, R., Washing fresh tea leaves before picking decreases pesticide residues in tea. Journal of the Science of Food and Agriculture 2020, 100, (13), 4921-4929.
Dai, H.; Gao, Q.; He, L., Rapid Determination of Saffron Grade and Adulteration by Thin-Layer Chromatography Coupled with Raman Spectroscopy. Food Analytical Methods 2020, 13, (11), 2128-2137.
Zhou, H.; Pandya, J. K.; Tan, Y.; Liu, J.; Peng, S.; Muriel Mundo, J. L.; He, L.; Xiao, H.; McClements, D. J., Role of mucin in behavior of food-grade TiO2 nanoparticles under simulated oral conditions. Journal of agricultural and food chemistry 2019, 67, (20), 5882-5890.
Zhang, Z.; Guo, H.; Ma, C.; Xia, M.; White, J. C.; Xing, B.; He, L., Rapid and efficient removal of silver nanoparticles from plant surfaces using sodium hypochlorite and ammonium hydroxide solution. Food Control 2019, 98, 68-73.
Yang, T.; Qu, Y.; Hickey, M.; Wang, W.; Zhao, B.; Bi, S.; Zhang, G.; He, L., Mapping of pesticide transmission on biological tissues by surface enhanced Raman microscopy with a gold nanoparticle mirror. ACS applied materials & interfaces 2019, 11, (47), 44894-44904.
Yang, T.; Doherty, J.; Guo, H.; Zhao, B.; Clark, J. M.; Xing, B.; Hou, R.; He, L., Real-time monitoring of pesticide translocation in tomato plants by surface-enhanced Raman spectroscopy. Analytical chemistry 2019, 91, (3), 2093-2099.
Wang, C.; Zhang, Z.; He, L., Development of a headspace solid‐phase microextraction–surface‐enhanced Raman scattering approach to detect volatile pesticides. Journal of Raman Spectroscopy 2019, 50, (1), 6-14.
Tu, Q.; Yang, T.; Qu, Y.; Gao, S.; Zhang, Z.; Zhang, Q.; Wang, Y.; Wang, J.; He, L., In situ colorimetric detection of glyphosate on plant tissues using cysteamine-modified gold nanoparticles. The Analyst 2019, 144, (6), 2017-2025.
Tu, Q.; Hickey, M. E.; Yang, T.; Gao, S.; Zhang, Q.; Qu, Y.; Du, X.; Wang, J.; He, L., A simple and rapid method for detecting the pesticide fipronil on egg shells and in liquid eggs by Raman microscopy. Food Control 2019, 96, 16-21.
Lin, Z.; He, L., Recent advance in SERS techniques for food safety and quality analysis: a brief review. Current Opinion in Food Science 2019, 28, 82-87.
Guo, J.; Tong, M.; Tang, J.; Bian, H.; Wan, X.; He, L.; Hou, R., Analysis of multiple pesticide residues in polyphenol-rich agricultural products by UPLC-MS/MS using a modified QuEChERS extraction and dilution method. Food chemistry 2019, 274, 452-459.
Guo, H.; Ma, C.; Thistle, L.; Huynh, M.; Yu, C.; Clasby, D.; Chefetz, B.; Polubesova, T.; White, J. C.; He, L., Transformation of Ag ions into Ag nanoparticle-loaded AgCl microcubes in the plant root zone. Environmental Science: Nano 2019, 6, (4), 1099-1110.
Guo, H.; Hamlet, L. C.; He, L.; Xing, B., A field-deployable surface-enhanced Raman scattering (SERS) method for sensitive analysis of silver nanoparticles in environmental waters. Science of The Total Environment 2019, 653, 1034-1041.
Gao, S.; He, L., Development of a filtration-based SERS mapping platform for specific screening of Salmonella enterica serovar Enteritidis. Analytical and bioanalytical chemistry 2019, 411, (29), 7899-7906.
Cao, X.; Han, Y.; Li, F.; Li, Z.; McClements, D. J.; He, L.; Decker, E. A.; Xing, B.; Xiao, H., Impact of protein-nanoparticle interactions on gastrointestinal fate of ingested nanoparticles: Not just simple protein corona effects. NanoImpact 2019, 13, 37-43.
Zhao, B.; Yang, T.; Zhang, Z.; Hickey, M. E.; He, L., A triple functional approach to simultaneously determine the type, concentration, and size of titanium dioxide particles. Environmental science & technology 2018, 52, (5), 2863-2869.
Zhang, Y.; Zhao, C.; Tian, G.; Lu, C.; Li, Y.; He, L.; Xiao, H.; Zheng, J., Simultaneous characterization of chemical structures and bioactivities of citrus-derived components using SERS barcodes. Food chemistry 2018, 240, 743-750.
Pearson, B.; Mills, A.; Tucker, M.; Gao, S.; McLandsborough, L.; He, L., Rationalizing and advancing the 3-MPBA SERS sandwich assay for rapid detection of bacteria in environmental and food matrices. Food microbiology 2018, 72, 89-97.
Liu, F.; Ma, D.; Luo, X.; Zhang, Z.; He, L.; Gao, Y.; McClements, D. J., Fabrication and characterization of protein-phenolic conjugate nanoparticles for co-delivery of curcumin and resveratrol. Food Hydrocolloids 2018, 79, 450-461.
Jiao, W.; Hu, Y.; Ge, G.; Li, J.; Xiao, Y.; Cai, H.; He, L.; Hua, R.; Sun, J.; Hou, R., Comparison of the metabolic behaviors of six systemic insecticides in a newly established cell suspension culture derived from tea (Camellia sinensis L.) leaves. Journal of agricultural and food chemistry 2018, 66, (32), 8593-8601.
Gukowsky, J. C.; Xie, T.; Gao, S.; Qu, Y.; He, L., Rapid identification of artificial and natural food colorants with surface enhanced Raman spectroscopy. Food Control 2018, 92, 267-275.
Gukowsky, J. C.; Tan, C.; Han, Z.; He, L., Cysteamine‐Modified Gold Nanoparticles as a Colorimetric Sensor for the Rapid Detection of Gentamicin. Journal of food science 2018, 83, (6), 1631-1638.
Gao, S.; Pearson, B.; He, L., Mapping bacteria on filter membranes, an innovative SERS approach. Journal of microbiological methods 2018, 147, 69-75.
Chen, H.; Wang, C.; Zhang, Z.; He, L., Combining Headspace Solid-Phase Microextraction and Surface-Enhanced Raman Spectroscopy To Detect the Pesticide Fonofos in Apple Juice. Journal of food protection 2018, 81, (7), 1087-1092.
Zheng, J.; Zhao, C.; Tian, G.; He, L., Rapid screening for ricin toxin on letter papers using surface enhanced Raman spectroscopy. Talanta 2017, 162, 552-557.
Zhao, B.; Cao, X.; De La Torre-Roche, R.; Tan, C.; Yang, T.; White, J.; Xiao, H.; Xing, B.; He, L., A green, facile, and rapid method for microextraction and Raman detection of titanium dioxide nanoparticles from milk powder. RSC advances 2017, 7, (35), 21380-21388.
Zhang, Y.; Zhao, S.; Zheng, J.; He, L., Surface-enhanced Raman spectroscopy (SERS) combined techniques for high-performance detection and characterization. TrAC Trends in Analytical Chemistry 2017, 90, 1-13.
Zhang, R.; Wu, W.; Zhang, Z.; Park, Y.; He, L.; Xing, B.; McClements, D. J., Effect of the composition and structure of excipient emulsion on the bioaccessibility of pesticide residue in agricultural products. Journal of agricultural and food chemistry 2017, 65, (41), 9128-9138.
Yang, Y.; Wang, X.; Zhao, C.; Tian, G.; Zhang, H.; Xiao, H.; He, L.; Zheng, J., Chemical mapping of essential oils, flavonoids and carotenoids in citrus peels by Raman microscopy. Journal of food science 2017, 82, (12), 2840-2846.
Yang, T.; Zhao, B.; Kinchla, A. J.; Clark, J. M.; He, L., Investigation of pesticide penetration and persistence on harvested and live basil leaves using surface-enhanced Raman scattering mapping. Journal of agricultural and food chemistry 2017, 65, (17), 3541-3550.
Yang, T.; Doherty, J.; Zhao, B.; Kinchla, A. J.; Clark, J. M.; He, L., Effectiveness of commercial and homemade washing agents in removing pesticide residues on and in apples. Journal of agricultural and food chemistry 2017, 65, (44), 9744-9752.
Wang, P.; Pang, S.; Pearson, B.; Chujo, Y.; McLandsborough, L.; Fan, M.; He, L., Rapid concentration detection and differentiation of bacteria in skimmed milk using surface enhanced Raman scattering mapping on 4-mercaptophenylboronic acid functionalized silver dendrites. Analytical and bioanalytical chemistry 2017, 409, (8), 2229-2238.
Tong, M.; Gao, W.; Jiao, W.; Zhou, J.; Li, Y.; He, L.; Hou, R., Uptake, translocation, metabolism, and distribution of glyphosate in nontarget tea plant (Camellia sinensis L.). Journal of agricultural and food chemistry 2017, 65, (35), 7638-7646.
Tan, C.; Zhao, B.; Zhang, Z.; He, L., Rapid detection of TiO2 (E171) in table sugar using Raman spectroscopy. Food Additives & Contaminants: Part A 2017, 34, (2), 183-191.
Tan, C.; Zhang, Z.; Qu, Y.; He, L., Ag2O/TiO2 nanocomposite heterostructure as a dual functional semiconducting substrate for SERS/SEIRAS application. Langmuir 2017, 33, (22), 5345-5352.
Qu, Y.; Tan, C.; Zhang, Z.; He, L., A facile solvent mediated self-assembly silver nanoparticle mirror substrate for quantitatively improved surface enhanced Raman scattering. The Analyst 2017, 142, (21), 4075-4082.
Pearson, B.; Wang, P.; Mills, A.; Pang, S.; McLandsborough, L.; He, L., Innovative sandwich assay with dual optical and SERS sensing mechanisms for bacterial detection. Analytical Methods 2017, 9, (32), 4732-4739.
Li, J.; Sang, H.; Guo, H.; Popko, J. T.; He, L.; White, J. C.; Dhankher, O. P.; Jung, G.; Xing, B., Antifungal mechanisms of ZnO and Ag nanoparticles to Sclerotinia homoeocarpa. Nanotechnology 2017, 28, (15), 155101.
Hou, R.; Tong, M.; Gao, W.; Wang, L.; Yang, T.; He, L., Investigation of degradation and penetration behaviors of dimethoate on and in spinach leaves using in situ SERS and LC-MS. Food chemistry 2017, 237, 305-311.
Guo, H.; He, L.; Xing, B., Applications of surface-enhanced Raman spectroscopy in the analysis of nanoparticles in the environment. Environmental Science: Nano 2017, 4, (11), 2093-2107.
Boushell, V.; Pang, S.; He, L., Aptamer‐Based SERS Detection of Lysozyme on a Food‐Handling Surface. Journal of food science 2017, 82, (1), 225-231.
Zhang, Z.; Guo, H.; Deng, Y.; Xing, B.; He, L., Mapping gold nanoparticles on and in edible leaves in situ using surface enhanced Raman spectroscopy. RSC advances 2016, 6, (65), 60152-60159.
Zhang, Z.; Guo, H.; Carlisle, T.; Mukherjee, A.; Kinchla, A.; White, J. C.; Xing, B.; He, L., Evaluation of postharvest washing on removal of silver nanoparticles (AgNPs) from spinach leaves. Journal of agricultural and food chemistry 2016, 64, (37), 6916-6922.
Zhang, H.; Zheng, J.; Liu, A.; Xiao, H.; He, L., Label-free imaging and characterization of cancer cell responses to polymethoxyflavones using raman microscopy. Journal of agricultural and food chemistry 2016, 64, (51), 9708-9713.
Yang, T.; Zhao, B.; Hou, R.; Zhang, Z.; Kinchla, A. J.; Clark, J. M.; He, L., Evaluation of the penetration of multiple classes of pesticides in fresh produce using surface‐enhanced Raman scattering mapping. Journal of food science 2016, 81, (11), T2891-T2901.
Yang, T.; Zhang, Z.; Zhao, B.; Hou, R.; Kinchla, A.; Clark, J. M.; He, L., Real-time and in situ monitoring of pesticide penetration in edible leaves by surface-enhanced Raman scattering mapping. Analytical chemistry 2016, 88, (10), 5243-5250.
Wang, P.; Pang, S.; Zhang, H.; Fan, M.; He, L., Characterization of Lactococcus lactis response to ampicillin and ciprofloxacin using surface-enhanced Raman spectroscopy. Analytical and bioanalytical chemistry 2016, 408, (3), 933-941.
Wang, P.; Pang, S.; Chen, J.; McLandsborough, L.; Nugen, S. R.; Fan, M.; He, L., Label-free mapping of single bacterial cells using surface-enhanced Raman spectroscopy. The Analyst 2016, 141, (4), 1356-1362.
Sanidad, K. Z.; Sukamtoh, E.; Wang, W.; Du, Z.; Florio, E.; He, L.; Xiao, H.; Decker, E. A.; Zhang, G., Oxidative conversion mediates antiproliferative effects of tert-butylhydroquinone: structure and activity relationship study. Journal of agricultural and food chemistry 2016, 64, (19), 3743-3748.
Pang, S.; Yang, T.; He, L., Review of surface enhanced Raman spectroscopic (SERS) detection of synthetic chemical pesticides. TrAC Trends in Analytical Chemistry 2016, 85, 73-82.
Pang, S.; He, L., Understanding the competitive interactions in aptamer–gold nanoparticle based colorimetric assays using surface enhanced Raman spectroscopy (SERS). Analytical Methods 2016, 8, (7), 1602-1608.
Ma, C.; Xiao, H.; He, L., Surface‐enhanced Raman scattering characterization of monohydroxylated polymethoxyflavones. Journal of Raman Spectroscopy 2016, 47, (8), 901-907.
Ling, C.; Li, X.; Zhang, Z.; Liu, F.; Deng, Y.; Zhang, X.; Li, A.; He, L.; Xing, B., High adsorption of sulfamethoxazole by an amine-modified polystyrene–divinylbenzene resin and its mechanistic insight. Environmental science & technology 2016, 50, (18), 10015-10023.
Hou, R.; Zhang, Z.; Pang, S.; Yang, T.; Clark, J. M.; He, L., Alteration of the nonsystemic behavior of the pesticide ferbam on tea leaves by engineered gold nanoparticles. Environmental science & technology 2016, 50, (12), 6216-6223.
Guo, H.; Xing, B.; White, J. C.; Mukherjee, A.; He, L., Ultra-sensitive determination of silver nanoparticles by surface-enhanced Raman spectroscopy (SERS) after hydrophobization-mediated extraction. The Analyst 2016, 141, (18), 5261-5264.
Guo, H.; Xing, B.; He, L., Development of a filter-based method for detecting silver nanoparticles and their heteroaggregation in aqueous environments by surface-enhanced Raman spectroscopy. Environmental pollution 2016, 211, 198-205.
Guo, H.; Xing, B.; Hamlet, L. C.; Chica, A.; He, L., Surface-enhanced Raman scattering detection of silver nanoparticles in environmental and biological samples. Science of The Total Environment 2016, 554, 246-252.
Gao, S.; Zhang, Z.; He, L., Filter-based surface-enhanced Raman spectroscopy for rapid and sensitive detection of the fungicide ferbam in water. International Journal of Environmental Analytical Chemistry 2016, 96, (15), 1495-1506.
Gao, S.; Glasser, J.; He, L., A filter-based surface enhanced Raman spectroscopic assay for rapid detection of chemical contaminants. Journal of visualized experiments: JoVE 2016, (108).
Dornath, P.; Ruzycky, S.; Pang, S.; He, L.; Dauenhauer, P.; Fan, W., Adsorption-enhanced hydrolysis of glucan oligomers into glucose over sulfonated three-dimensionally ordered mesoporous carbon catalysts. Green Chemistry 2016, 18, (24), 6637-6647.
Chen, J.; Pang, S.; He, L.; Nugen, S. R., Highly sensitive and selective detection of nitrite ions using Fe3O4@ SiO2/Au magnetic nanoparticles by surface-enhanced Raman spectroscopy. Biosensors and Bioelectronics 2016, 85, 726-733.
Cao, X.; Ma, C.; Gao, Z.; Zheng, J.; He, L.; McClements, D. J.; Xiao, H., Characterization of the interactions between titanium dioxide nanoparticles and polymethoxyflavones using surface-enhanced Raman spectroscopy. Journal of agricultural and food chemistry 2016, 64, (49), 9436-9441.
Yao, M.; He, L.; McClements, D. J.; Xiao, H., Uptake of gold nanoparticles by intestinal epithelial cells: impact of particle size on their absorption, accumulation, and toxicity. Journal of agricultural and food chemistry 2015, 63, (36), 8044-8049.
Pang, S.; Ma, C.; Zhang, N.; He, L., Investigation of the solubility enhancement mechanism of rebaudioside D using a solid dispersion technique with potassium sorbate as a carrier. Food chemistry 2015, 174, 564-570.
Lang, T.; Pang, S.; He, L., Integration of colorimetric and SERS detection for rapid screening and validation of melamine in milk. Analytical Methods 2015, 7, (15), 6426-6431.
Hou, R.; Pang, S.; He, L., In situ SERS detection of multi-class insecticides on plant surfaces. Analytical Methods 2015, 7, (15), 6325-6330.
Guo, H.; Zhang, Z.; Xing, B.; Mukherjee, A.; Musante, C.; White, J. C.; He, L., Analysis of silver nanoparticles in antimicrobial products using surface-enhanced Raman spectroscopy (SERS). Environmental science & technology 2015, 49, (7), 4317-4324.
Chen, J.; Song, M.; Wu, X.; Zheng, J.; He, L.; McClements, D. J.; Decker, E.; Xiao, H., Direct fluorescent detection of a polymethoxyflavone in cell culture and mouse tissue. Journal of agricultural and food chemistry 2015, 63, (49), 10620-10627.
Chen, J.; Li, Y.; Huang, K.; Wang, P.; He, L.; Carter, K. R.; Nugen, S. R., Nanoimprinted patterned pillar substrates for surface-enhanced Raman scattering applications. ACS applied materials & interfaces 2015, 7, (39), 22106-22113.
Zheng, J.; Pang, S.; Labuza, T. P.; He, L., Evaluation of surface-enhanced Raman scattering detection using a handheld and a bench-top Raman spectrometer: A comparative study. Talanta 2014, 129, 79-85.
Zheng, J.; He, L., Surface‐enhanced Raman spectroscopy for the chemical analysis of food. Comprehensive reviews in food science and food safety 2014, 13, (3), 317-328.
Winuprasith, T.; Suphantharika, M.; McClements, D. J.; He, L., Spectroscopic studies of conformational changes of β-lactoglobulin adsorbed on gold nanoparticle surfaces. Journal of colloid and interface science 2014, 416, 184-189.
Winuprasith, T.; Chantarak, S.; Suphantharika, M.; He, L.; McClements, D. J., Alterations in nanoparticle protein corona by biological surfactants: Impact of bile salts on β-lactoglobulin-coated gold nanoparticles. Journal of colloid and interface science 2014, 426, 333-340.
Wijaya, W.; Pang, S.; Labuza, T. P.; He, L., Rapid detection of acetamiprid in foods using Surface‐Enhanced Raman Spectroscopy (SERS). Journal of food science 2014, 79, (4), T743-T747.
Pang, S.; Labuza, T. P.; He, L., Development of a single aptamer-based surface enhanced Raman scattering method for rapid detection of multiple pesticides. The Analyst 2014, 139, (8), 1895-1901.
Li, Y.; Driver, M.; Winuprasith, T.; Zheng, J.; McClements, D. J.; He, L., In situ SERS detection of emulsifiers at lipid interfaces using label-free amphiphilic gold nanoparticles. The Analyst 2014, 139, (20), 5075-5078.
Li, Y.; Driver, M.; Decker, E.; He, L., Lipid and lipid oxidation analysis using surface enhanced Raman spectroscopy (SERS) coupled with silver dendrites. Food research international 2014, 58, 1-6.
He, L.; Chen, T.; Labuza, T. P., Recovery and quantitative detection of thiabendazole on apples using a surface swab capture method followed by surface-enhanced Raman spectroscopy. Food chemistry 2014, 148, 42-46.
Zheng, J.; Pang, S.; Labuza, T. P.; He, L., Semi-quantification of surface-enhanced Raman scattering using a handheld Raman spectrometer: a feasibility study. The Analyst 2013, 138, (23), 7075-7078.
Zheng, J.; Fang, X.; Xiao, H.; He, L., Rapid quantification of nobiletin and tangeretin in citrus peel extractions by raman spectroscopy. J Food Process & Beverages 2013, 1, 4.
Zheng, J.; Fang, X.; Cao, Y.; Xiao, H.; He, L., Monitoring the chemical production of citrus-derived bioactive 5-demethylnobiletin using surface-enhanced Raman spectroscopy. Journal of agricultural and food chemistry 2013, 61, (34), 8079-8083.
Wang, Q.; He, L.; Labuza, T. P.; Ismail, B., Structural characterisation of partially glycosylated whey protein as influenced by pH and heat using surface-enhanced Raman spectroscopy. Food chemistry 2013, 139, (1-4), 313-319.
He, L.; Zheng, J.; Labuza, T. P.; Xiao, H., A surface enhanced Raman spectroscopic study of interactions between casein and polymethoxyflavones. Journal of Raman Spectroscopy 2013, 44, (4), 531-535.
He, L.; Deen, B. D.; Pagel, A. H.; Diez-Gonzalez, F.; Labuza, T. P., Concentration, detection and discrimination of Bacillus anthracis spores in orange juice using aptamer based surface enhanced Raman spectroscopy. The Analyst 2013, 138, (6), 1657-1659.
Lamont, E. A.; He, L.; Warriner, K.; Labuza, T. P.; Sreevatsan, S., A single DNA aptamer functions as a biosensor for ricin. The Analyst 2011, 136, (19), 3884-3895.
He, L.; Shi, J.; Sun, X.; Lin, M.; Yu, P.; Li, H., Gold coated zinc oxide nanonecklaces as a SERS substrate. Journal of nanoscience and nanotechnology 2011, 11, (4), 3509-3515.
He, L.; Rodda, T.; Haynes, C. L.; Deschaines, T.; Strother, T.; Diez-Gonzalez, F.; Labuza, T. P., Detection of a foreign protein in milk using surface-enhanced Raman spectroscopy coupled with antibody-modified silver dendrites. Analytical chemistry 2011, 83, (5), 1510-1513.
He, L.; Liu, Y.; Mustapha, A.; Lin, M., Antifungal activity of zinc oxide nanoparticles against Botrytis cinerea and Penicillium expansum. Microbiological research 2011, 166, (3), 207-215.
He, L.; Lamont, E.; Veeregowda, B.; Sreevatsan, S.; Haynes, C. L.; Diez-Gonzalez, F.; Labuza, T. P., Aptamer-based surface-enhanced Raman scattering detection of ricin in liquid foods. Chemical Science 2011, 2, (8), 1579-1582.
He, L.; Haynes, C. L.; Diez‐Gonzalez, F.; Labuza, T. P., Rapid detection of a foreign protein in milk using IMS–SERS. Journal of Raman Spectroscopy 2011, 42, (6), 1428-1434.
He, L.; Deen, B.; Rodda, T.; Ronningen, I.; Blasius, T.; Haynes, C.; Diez‐Gonzalez, F.; Labuza, T. P., Rapid detection of ricin in milk using immunomagnetic separation combined with surface‐enhanced Raman spectroscopy. Journal of food science 2011, 76, (5), N49-N53.
He, L.; Lin, M.; Li, H.; Kim, N. J., Surface‐enhanced Raman spectroscopy coupled with dendritic silver nanosubstrate for detection of restricted antibiotics. Journal of Raman Spectroscopy 2010, 41, (7), 739-744.
Liu, Y.-j.; He, L.-l.; Mustapha, A.; Li, H.; Hu, Z.; Lin, M.-s., Antibacterial activities of zinc oxide nanoparticles against Escherichia coli O157: H7. Journal of applied microbiology 2009, 107, (4), 1193-1201.
Lin, M.; He, L.; Awika, J.; Yang, L.; Ledoux, D.; Li, H. a.; Mustapha, A., Detection of melamine in gluten, chicken feed, and processed foods using surface enhanced Raman spectroscopy and HPLC. Journal of food science 2008, 73, (8), T129-T134.
He, L.; Liu, Y.; Lin, M.; Mustapha, A.; Wang, Y., Detecting single Bacillus spores by surface enhanced Raman spectroscopy. Sensing and Instrumentation for Food Quality and Safety 2008, 2, (4), 247-253.
He, L.; Liu, Y.; Lin, M.; Awika, J.; Ledoux, D. R.; Li, H.; Mustapha, A., A new approach to measure melamine, cyanuric acid, and melamine cyanurate using surface enhanced Raman spectroscopy coupled with gold nanosubstrates. Sensing and Instrumentation for Food Quality and Safety 2008, 2, (1), 66-71.
He, L.; Kim, N.-J.; Li, H.; Hu, Z.; Lin, M., Use of a fractal-like gold nanostructure in surface-enhanced Raman spectroscopy for detection of selected food contaminants. Journal of agricultural and food chemistry 2008, 56, (21), 9843-9847.

Full CV

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