Matthew D. Moore

Food microbiology; food and environmental virology; eukaryotic virus-bacteria interactions; portable detection and sequencing platforms; viral inactivation strategies and therapeutics; viral concentration techniques.

My research primarily focuses on food safety microbiology; especially with a focus on foodborne viruses. Foodborne viruses are the leading cause of foodborne illnesses, especially human noroviruses. These viruses impose a severe public health and economic burden globally every year. Human noroviruses are responsible for over 200,000 deaths globally every year—many of which are children under the age of 5—and impose an economic burden in the billions of dollars. Our lab’s research can be divided into a few broad categories:

1. Eukaryotic Virus-Bacteria Interactions. A number of reports have suggested there is a relationship between viruses that infect eukaryotic cells and the native bacterial flora present on/around the tissues that the viruses infect. This is especially true for the human gut. There is some suggestion that some native enteric bacteria may play a role in assisting infection of some enteric viruses—including human noroviruses. Additionally, there are some reports that binding to bacterial cellular membrane components may stabilize enteric viruses, and make them harder to inactivate. Conversely, there is some evidence that other bacteria may have an antiviral effect. Our lab is conducting research to explain this discrepancy and further understand the nature of eukaryotic virus-bacteria interactions in the gut.

2. Novel Viral Concentration Methods from Food and Environmental Samples. Food- and waterborne viruses are present in contaminated samples at low levels and not evenly dispersed throughout the samples. Unlike bacteria, an enrichment step for routine food and environmental testing is not feasible for viruses; thus a small amount of viruses must be concentrated from large, complex samples. Our lab is doing research on cheap, efficient ways of concentrating viruses from foods for detection.

3. Rapid, Portable Point-of-Service/In-Field Testing Methods for Foodborne Viruses. Humans are the recognized reservoir for human noroviruses; thus a lot of transmission is attributable to person-to-person spread, especially in confined settings. The majority of cases of foodborne human norovirus illness occur in complex, prepared foods, and most outbreaks are traced to restaurant or similar service settings. In both instances, the current methods for detection of viruses are either not portable or not sensitive enough for realistic use in these settings. Our lab will be doing work on developing methods that allow for sensitive “lab-in-a-suitcase” methods for detection of human noroviruses and other foodborne viruses that allow for rapid detection of virus from sample in less than 30 minutes without the need for an electrical grid. These methods would also have value in low resource settings, where detection and control of viral outbreaks is essential for reducing severe health outcomes. Additionally, our lab will focus on portable sequencing platforms for these viruses, as following evolutionary trends can provide valuable data for control and prediction of emerging viral strains of concern.

4. Novel Viral Inactivation Strategies and Therapeutics. Human noroviruses have been found to be fairly resistant to many disinfectants. Bleach at fairly high levels has been shown to be effective, but is often not used because of its effects on certain materials. Our lab will investigate application of novel disinfectants on human noroviruses and understand the effect of soil load on the efficacy of those disinfectants. Our lab will also be involved in developing therapeutics to a human norovirus protein necessary for replication; the ultimate goal of this area of research would be to develop an inexpensive, edible therapeutic that has little residual effects on the host. 

FOOD-SCI 567: Food Microbiology Lecture, 3 Credits

FOOD-SCI 790S: Advanced Topics in Food Safety

FOOD-SCI 797V: Biosensors and Pathogen Detection, 1 Credit (Journal Club)

Honors and Awards Since 2018

2024-2030      Eric A. Decker Scholar, Department of Food Science, University of Massachusetts, Amherst

2024                Institute of Food Technologists (IFT) Outstanding Young Scientist Award in honor of Samuel Cate Prescott

2018                International Union of Food Science and Technology Young Scientist Award (one of seven winners from field of international candidates)

2018                International Academy of Food Science and Technology, Early Career Scientist Inductee

2018                IFT Emerging Leaders Network

2018-2021      American Society for Microbiology Young Ambassador from Massachusetts

Publications in Scientific Journals

 (*Listed as Corresponding or Co-Corresponding Author; #UMass Affiliation Listed; Graduate Student Advisee; Undergraduate Student Advisee):

*62.   Abedi‑Firouzjah R, Tavassoli  M, Khezerlou A, Mazaheri Y, Alizadeh‑Sani M, Ehsani A, Moore MD. 2024. Recent advances in applications of aptasensors/nanomaterials platform for food and biomedical: A review. Food Analytical Methods. https://doi.org/10.1007/s12161-024-02693-8.

*61.   Kaur S, Singla P, Dann A, McClements J, Sullivan M, Kim M, Stoufer S, Dawson J, Crapnell R, Banks C, Turner N, Moore MD#*, Kaur I, Peeters M. 2024. Sensitive Electrochemical and Thermal Detection of Human Noroviruses Using Molecularly Imprinted Polymer Nanoparticles Generated against a Viral Target. ACS Applied Materials & Interfaces. (In Press).

60.     Safavizadeh V, Ali S, Fernandes de Oliveira CA, Moore MD#, Naderi-Manesh H, Nemati M, Rostami M. 17 Aug 2024.The occurrence of tenuazonic acid in food products: a systematic review. Toxin Reviews. DOI: 10.1080/15569543.2024.2392118. IF (2023) = 3.3.

59.     Lin T-C, Daddi L, Tang Y, Zhou Y, Moore MD#, Liu Z. Antrodia camphorata supplementation during early life alters gut microbiota and inhibits young-onset intestinal tumorigenesis in APC^163N mice later in life. Nutrients 16(15):2408.

*58.   Allingham C, Tanaguchi M, Kinchla A, Moore MD#*. The influence of simulated organic matter on the inactivation of viruses: A review. Viruses 16(7):1026. IF (2022) = 3.8.

*57.   Guan B, Hong H, Kim M, Lu J, Moore MD#*. Evaluating the potential of ozone microbubbles for inactivation of Tulane virus, a human norovirus surrogate. ACS Omega 9(22):23184-23192. IF (2022) = 4.1.

56.     Abdel-Moneim AS, Murovska M, Söderlund-Venermo M, Vakharia VN, Wilson WC, Gladue DP, Moore MD, Alonso C, Abdelwahab SF, Venter M, Malik YS, Saxena SK, Shi Z, Varma A, Kuhn RJ. 2024. WSV2023 - The Second Meeting of the World Society for Virology: One Health - One World - One Virology. Virology 594:110049. IF (2022) = 2.8.

55.     Rafieepoor M, Hosseini SM, Tanhaei M, Niasar MS, Kazemian S, Moore MD, Zali MR. 2024. Detection of human enteric viruses in fresh produce of markets, farms and surface water used for irrigation in the Tehran, Iran. Science of the Total Environment 912:169575. IF (2022) = 8.2.

54.     Lin T-C, Guan Y, Tang Y, Soorneedi A, Moore MD#, Liu Z. 2023. Turicibacter fermentation enhances the inhibitory effects of Antrodia camphorata supplementation on tumorigenic serotonin and Wnt pathways and promotes ROS-mediated apoptosis of Caco-2 cells. Frontiers in Pharmacology 14:1203087. IF (2022): 5.6.

*53.   Stoufer S, Soorneedi A, Kim M, Moore MD#*. 2024. Sample concentration and processing methods for viruses from foods and the environment prior to detection. Annual Reviews in Food Science and Technology 15(1):455-472. IF (2022): 14.7.

52.     Gensler C, Harper K, Stoufer S, Moore MD#, Kinchla A. 2023. Exploring washing procedures for produce brush washers Journal of Food Protection. 86(9): 100126. IF (2022): 2.8.

*51.   Kim M, Foster J, Moore MD#*, Chen M. 2023. Improving Single-Molecule Antibody Detection Selectivity through Optimization of Peptide Epitope Presentation in OmpG Nanopore. ACS Sensors 8(7): 2673–2680. IF (2021): 9.62.

50.     Dilpreet S’, Soorneedi A’, Vaze N, Domitrovic R, Sharp F, Lindsey D, Rohr A, Moore MD#, Koutrakis P, Nardell E, Demokritou P. 2023. Assessment of SARS-CoV-2 surrogate inactivation on surfaces and in air using UV and blue light-based intervention technologies. Journal of the Air & Waste Management Association 73(3):200-211. ‘Equal Contribution. IF (2021) = 3.36.

*49.   Stoufer S, Demokritou M, Buckley D, Teska P, Moore MD#*. 2023. Evaluation of Commercial Disinfectants’ Ability to Degrade Free Nucleic Acids Commonly Targeted using Molecular Diagnostics. Journal of Hospital Infection 133:28-37. IF (2021) = 8.94.

48.     Foster JC, Pham B, Pham R, Kim M, Moore MD#, Chen M. 2023. An engineered OmpG nanopore with displayed peptide motifs for single-molecule multiplex protein detection. Angewandte Chemie 62(7): e202214566. IF (2021) = 16.82.

47.     Safavizadeh V, Moggadam MRA, Farajzadeh MA, Mojkar M, Moore MD#, Nokhodchi A, Naebi M, Nemati M. 2023. Descriptions in toxicology, interactions, extraction, and analytical methods of Aflatoxins; a 10-year study performed in Iranian foodstuffs. International Journal of Environmental Analytical Chemistry 103(3):701-711. IF (2021) = 2.73.

*46.   Soorneedi A, Moore MD#*. 2022. Recent developments in noroviruses interactions with bacteria. Current Opinion in Food Science 48:100926. IF (2021) = 9.8.

*45.   Suther C, Devon L, Daddi L, Matson A, Panier H, Yuan H, Saar K, Bokoliya S, Dorsett Y, Sela DA, Beigelman A, Moore MD#*, Zhou Y*. 2022. Dietary Indian frankincense (Boswellia serrata) ameliorates murine allergic asthma through modulation of the gut microbiome. Journal of Functional Foods 97:105249. IF (2021) = 5.22.

44.     Rafieepoor M, Mohebbi SR, Hosseini SM, Tanhaei M, Niasar MS, Kazemian SK, Aghdaei HA, Moore MD#, Zali MR. 2022. Detection of SARS-CoV-2 RNA in farms, markets, and fresh leafy green vegetables from Tehran, Iran. 2022. Frontiers in Public Health 10:823061. IF (2021) = 6.46.

*43.   Alavia M*, Kamarasu P, McClements DJ, Moore MD#*. 2022. Metal and metal oxide-based antiviral nanoparticles: Properties, mechanisms of action, and applications. Advances in Colloid and Interface Science 306: 102726. IF (2021) = 15.19.

42.     Vaze N’, Soorneedi A’, Moore MD#, Demokritou P. 2022. Inactivating SARS-CoV-2 surrogates on surfaces using Engineered Water Nanostructures incorporated with nature derived antimicrobials. Nanomaterials 12(10):1735. ‘Equal Contribution. IF (2021) = 5.72.

*41.   Schoen C, Morgan E, Muilenberg M, Rogers C, Soorneedi A, Suther C, Leftwich H, Moore MD#*. 2022. Failure to Detect SARS-CoV-2 RNA in the Air During Active Labor in Mothers Who Recently Tested Positive. Frontiers in Public Health 10: 881613. IF (2021) = 6.46.

*40.   Mertens BS, Moore MD#*, Jaykus L-A, Velev OD. 2022. Efficacy and mechanisms of copper ion-catalyzed inactivation of human norovirus. American Chemical Society Infectious Diseases 8(4):855-864. IF (2021) = 5.58.

*39.   Suther C, Daddi L, Bokoliya S, Panier H, Liu Z, Qingqi L, Han Y, Chen K, Moore MD#*, Zhou Y. 2022. Dietary Boswellia serrata acid alters gut microbiome and blood metabolites. Nutrients 14(4):814. IF (2021) = 6.71.

*38.   Suther C, Stoufer S, Zhou Y, Moore MD#*. 2022. Recent Developments in Isothermal Amplification Methods for the Detection of Foodborne Viruses. “Rising Stars in Virology: 2022” Special Issue, Frontiers in Microbiology 13:841875. IF (2021) = 6.06.

37.     Söderlund-Venermo M; Varma A; Guo D; Gladue DP; Poole E; Pujol FH; Pappu H; Romalde J; Kramer L; Baz M; Venter V; Moore MD#; Nevels MM; Ezzikouri S; Vakharia VN; Wilson WC; Malik Y; Shi Z; Abdel-Moneim A. 2022. World Society for Virology First International Conference: Tackling Global Virus Epidemics. Virology. 566:114-121. IF (2021) = 3.51.

*36.   Safavizadeh V, Fernandes de Oliveira CA, Nekoukar Z, Mohammadi MA, Tognon G, Moore MD#*. 2022. Occurrence of aflatoxin B1 in imported cinnamon consumed in the Yazd province of Iran. Food Additives and Contaminants – Part B. 15(1):52-55. IF (2021) = 3.96.

35.     Martinez-Ramos P, Goulette T, Stoufer S, Moore MD#, Corradini M, Autio W, Kinchla A. 2022. Preparation methods to produce a postharvest wash water model: Assessment and validation for use in food safety studies. ACS Food Science and Technology 2(1):57-65. IF = TBD.

34.     Shi L, Xia H, Moore MD#, Deng C, Li N, Ren H, Chen Y, Liu J, Du F, Zheng G, Li J, Liu H, Wang Y, Yang J, Liu Q, Zhao Y, Chen T. 2021. Metagenomic Next-Generation Sequencing in the Diagnosis of HHV-1 Reactivation in a Critically Ill COVID-19 Patient: A Case Report. Frontiers in Medicine 8:715519. IF (2021) = 5.06.

*33.   Moore MD#*, Faircloth J, Stoufer S, Kim M, Jaykus L-A. 2021. Generation of ssDNA aptamer candidates against a novel calicivirus protein target. Viruses 13: 1716. IF (2021) = 5.82.

*32.   Manuel C, Suther C, Moore MD#*, Jaykus L-A. 2021. Comparison of a one-step real-time RT-PCR and a nested real-time RT-PCR for a genogroup II norovirus reveals differences in sensitivity depending upon assay design and visualization. PLoS One 16(4): e0248581. IF (2021) = 3.75.

*31.   Delshadi R, Bahrami A, McClements DJ, Moore MD#*, Williams L. 2021. Development of nanoparticle-delivery systems for antiviral agents: A review. Journal of Controlled Release 331:30-44. IF (2021) = 11.47.

30.     Huang R, Vaze N, Soorneedi A, Moore MD#, Luo Y, Poverenov E, Rodov V, Demokritou P. 2021. A Novel Antimicrobial Technology to Enhance Food Safety and Quality of Leafy Vegetables using Engineered Water Nanostructures. Environmental Science: Nano 8:514-526. IF (2021) = 9.47.

*29.   Moore MD#*, Suther C, Zhou Y. 2021. Microbiota, viral infection, and the relationship to human diseases and treatment. Infectious Microbes & Diseases 3(1):1-3. IF = TBD.

28.     Suther C, Moore MD#, Beigelman A, Zhou Y. 2020. The gut microbiome and the big eight. Nutrients 12(12):3728. IF (2021) = 6.71.

27.     Aasi A, Aghaei SM, Moore MD#, Panchapakesan B. 2020. Pt-, Rh-, Ru-, and Cu-single-wall carbon nanotubes are exceptional candidates for design of anti-viral surfaces: A theoretical study. International Journal of Molecular Sciences 21(15):5211-5233. IF (2021) = 6.21.

26.     Hosein HI, Moore MD#, Abdel-Moneim AS. 2020. Known SARS-CoV-2 infections: The tip of an important iceberg. International Journal of Health Planning and Management 35(5):1270-1273. IF (2021) = 2.30.

*25.   Liu L, Moore MD#*. 2020. A survey of analytical techniques for noroviruses. Foods 9(3):E318. IF (2021) = 5.56.

24.     Abdel-Moneim A, Moore MD#, Naguib M, Romalde JL, Soderlund-Venermo M. 2020. WSV 2019: The 1^st Committee Meeting of the World Society for Virology. Virologica Sinica 35: 248–252. IF (2021) = 6.95.

23.     Huang R, Vaze N, Soorneedi A, Moore MD#, Xue Y, Bello D, Demokritou P. 2019. Inactivation of hand hygiene related pathogens using engineered water nanostructures. American Chemical Society Sustainable Chemistry and Engineering 7(24):19761-19769. IF (2021) = 9.22.

22.     Almand E, Moore MD#, Jaykus L-A. 2019. Determination and characterization of human norovirus binding to gut-associated bacteria and identification of candidate ligands involved. BMC Research Notes 12:607. IF (2021) = 2.15.

*21.   Suther C, Moore MD#*. 2019. Quantification and discovery of PCR inhibitors found in food matrices commonly associated with foodborne viruses. Food Science and Human Wellness 8(4):351-355. IF (2021) = 8.02.

20.     Brown P, RELISH Consortium#, Zhou Y. 2019. Large expert-curated database for benchmarking document similarity detection in biomedical literature search. Database 2019:baz085. IF (2021) = 4.46.

*19.   Kamarasu P, Hsu H, Moore MD#*. 2018. Research Progress in Viral Inactivation Utilizing Human Norovirus Surrogates. Frontiers in Sustainable Food Systems 2:89. IF (2021) = 5.01.

*18.   Manuel C, Moore MD#*, Jaykus L-A. 2018. Predicting Human Norovirus Infectivity: Recent Advances and Continued Challenges. Food Microbiology 76:337-345. IF (2021) = 5.91.

*17.   Moore MD#*, Jaykus L-A. 2018. Virus-Bacteria Interactions: Implications and Potential for the Applied and Agricultural Sciences. Viruses, Special Issue, “Virus-Bacteria Interactions in the Gut,” 10(2): 61. IF (2021) = 5.82.

Publications Prior to Joining UMass

16.     Tagg KA, Watkins LF, Moore MD, Bennett C, Chen JC, Folster JP. 2018. Novel Trimethoprim Resistance Gene dfrA34 identified in Salmonella Heidelberg in the USA. Journal of Antimicrobial Chemotherapy, dky373. IF (2021) = 5.76.

15.     Suh SH, Choi SJ, Dwivedi HP, Moore MD, Escudero-Abarca BI, Jaykus L-A. 2018. Use of a DNA Aptamer for Sandwich Type Detection of Listeria monocytogenes. Analytical Biochemistry 557:27-33. IF (2021) = 3.19.

14.     Abdel-Moneim A, Varma A, Pujol F, Lewis G, Paweska J, Romalde J, Moore MD#, Söderlund-Venermo M, Nevels M, Vakharia V, Joshi V, Malik Y, Shi Z-L, Memish Z. 2018. Launching a Global Network of Virologists: The World Society for Virology (WSV). Intervirology 62511:1-2. IF (2021) = 2.29.

*13.   Almand E, Moore MD#*, Jaykus L-A. 2017. Norovirus Binding to Ligands Beyond Histo-Blood Group Antigen Ligands. Frontiers in Microbiology 8: 2549. IF (2021) = 6.06.

*12.   Moore MD*, Mertens BS, Jaykus L-A. 2017. Alternative In Vitro Methods for the Determination of Viral Capsid Structural Integrity. Journal of Visual Experimentation e56444.     IF (2021) = 1.36.

*11.   Moore MD*, Jaykus L-A. 2017. Recombinase Polymerase Amplification: A Promising Point-of-Care Detection Method for Enteric Viruses. Future Virology 12(8): 421-429. IF (2021) = 3.02.

*10.   Moore MD*, Jaykus L-A. 2017. A Plate-Based Histo-Blood Group Antigen Binding Assay for Evaluation of Human Norovirus Receptor Binding Affinity. Analytical Biochemistry 533: 56-59. IF (2021) = 3.19.

*9.     Almand EA, Moore MD*, Jaykus L-A. 2017. Virus-Bacteria Interactions: An Emerging Topic in Human Infection. Viruses 9(3): 58-68. IF (2021) = 5.82.

8.       Almand EA, Moore MD*, Outlaw J, Jaykus L-A. 2017. Human Norovirus Binding to Select Bacteria Representative of the Human Gut Microbiota. PLoS One. 12(3): e01724. IF (2021) = 3.75.

*7.     Moore MD*, Jaykus L-A. 2017. Development of a Recombinase Polymerase Amplification Assay for Detection of Epidemic Human Noroviruses. Scientific Reports 7:40244. IF (2021) = 5.00.

6.       Manuel C, Moore MD, Jaykus L-A. 2017. Inactivation of GI.6 and GII.4 Human Norovirus by Silver Dihydrogen Citrate. Journal of Applied Microbiology 122(1):78-86. IF (2021) = 4.06.

*5.     Moore MD*, Bobay BG, Mertens B, Jaykus L-A. 2016. Human Norovirus Aptamer Exhibits High Degree of Target Conformation-Dependent Binding Similar to that of Receptors and Discriminates Particle Functionality. mSphere 1(6): e00289-16. IF (2021) = 4.17.

4.       Manuel C, Moore MD, Jaykus L-A. 2015. Rapid Destruction of Human Norovirus Capsid and Genome Occurs during Exposure to Copper-containing Surfaces. Applied and Environmental Microbiology 81(15): 4940-4946. IF (2021) = 5.01.

*3.     Moore MD*, Escudero-Abarca BI, Suh S, Jaykus L-A. 2015. Generation and Characterization of Nucleic Acid Aptamers Targeting the Capsid P Domain of a Human Norovirus GII.4 Strain. Journal of Biotechnology 209:41-49. IF (2021) = 3.60.

2.       Moore MD, Goulter RM, Jaykus L-A. 2015. Human Norovirus as a Foodborne Pathogen: Challenges and Developments. Annual Review of Food Science and Technology 6(1): 411-413. IF (2021) = 14.71.

1.       Escudero-Abarca BI, Suh SH, Moore MD, Dwivedi HP, Jaykus L-A. 2014. Selection, Characterization and Application of Nucleic Acid Aptamers for the Capture and Detection of Human Norovirus. PloS One 9(9):e106805. IF (2021) = 3.75.

Other Publications

(*Listed as Corresponding or Co-Corresponding Author; #UMass Affiliation Listed; Graduate Student Advisee):

7.       Dann A, Kaur S, Stoufer S, Kim M, Kaur I, Moore MD#, Peeters M, McClements J. 2023. Imprinted Polymers for Detection of Chemical and Microbial Contaminants in Foods. Textbook Chapter. Encyclopedia of Food Safety, 2^nd Edition, Ed. Byron Brehm-Stecher.

6.       Moore MD#, Anderson J, Bisha B, Brehm-Stecher B. 2023. Sample Preparation for Detection of Microbiological and Chemical Analytes. Textbook Chapter. Encyclopedia of Food Safety, 2^nd Edition, Ed. Byron Brehm-Stecher.

*5.     Moore MD#*, Stoufer S, Soorneedi A. Dangerous Needles in Tasty Haystacks: The Importance of Sample Concentration Prior to Rapid Detection. Global Food Safety Resource. Published Online, January 2022.

*4.     Jones MK, Almand EA, Soorneedi A, Moore MD#*. 2022. Chapter 10: Eukaryotic virus interactions with bacteria: Implications for pathogenesis and control. Textbook Chapter. The Biological Role of a Virus. Advances in Environmental Microbiology Series, Vol. 9. Springer. Ed. C. Hurst; 343-367.

*3.     Moore MD#*. 2019. Human noroviruses and gut bacteria: Friends, frenemies, or both? Microbiology Today, May 2019.

*2.     Moore MD*, Jaykus L-A. 2017. Use of an Enzyme-Linked Aptamer Sorbent Assay to Evaluate Aptamer Binding. Textbook Chapter. Synthetic Antibodies (Methods in Molecular Biology Series), Ed. Thomas Tiller, Vol. 1575: 291-302.

*1.     Moore MD#*, Jaykus L-A. Editor. Foodborne Viruses: Properties, Detection, and Control. Textbook, Royal Society of Chemistry. (In Preparation).

Patents

(#UMass Affiliation Listed; Graduate Student Advisee):

3.       Chen M, Foster J, Kim M, Moore MD#. June 22, 2022. Nanopore biosensors and uses thereof. US Provisional Patent Application, Serial No. 63/366,786.

2.       Jaykus L-A, Rawsthorne H, Escudero-Abarca BI, Moore MD. 1/5/2021 – 6/12/2035. Aptamers with Binding Affinity to Norovirus. US Patent, US10883149B2.

1.       Anderson J, Clark KD, Hice S, Stoufer S, Moore MD#, Brehm-Stecher B. Magnetic Ionic Liquids for Capture, Concentration and Molecular Detection of Microbes. (Patent in Preparation, Currently Working on Invention Disclosure).