Hang Xiao

Professor, Graduate Program Director

Faculty
Hang Xiao
Contact
Email
Email
Phone
Location
Room 338, Chenoweth Laboratory

Field of Study

Food-based strategy for health & wellness, the interplay between food components and gut microbiome, the health impact of a plant-based diet, bioavailability and metabolism of food components, enhancement of health benefits of food components by food processing, and toxicology of food components.

Research

My research is focused on identifying and characterizing food components that can modify human health positively or negatively, elucidating their molecular mechanisms, investigating possible interactions among these food components, and modifying biological activities and bioavailability of food components by food processing and nanotechnology with the long-term goal of developing food-based strategies for better health & wellness. A key focus of current research is on the interactions among food components, human body and gut microbiome in the context of health impacts. The role of a plant-based diet in human health is another focus of my research, and we are using novel food technology to enhance the health function of plant-based food and food components. I am also working on the toxicology of food components, such as certain food additives. The major approach of my research is the combination of chemistry, biochemistry, molecular biology, and nanotechnology in cell cultures, animal models, and human trials. 

Teaching

FS101 Food & Health 

FS265 Survey of Food Science 

FS266 Survey of Food Science Lab 

FS391A Food Science Undergraduate Research Experience

FS745 Advanced Food Biochemistry 

Awards

• Elected Fellow, Institute of Food Technologies (IFT), 2020

• Babcock-Hart Award, Institute of Food Technologies (IFT), 2019

• Elected Fellow, Agricultural and Food Chemistry Division, American Chemical Society (ACS), 2017

• Fergus M. Clydesdale Scholar of Food Science (2017-2022)

• Samuel Cote Prescott Research Award, Institute of Food Technologies (IFT), 2014

• Outstanding Service Award, Food Chemistry Division, Institute of Food Technologies (IFT), 2014

• Armstrong Fund of Science Award, UMass Amherst, 2014

• Mary Swartz Rose Young Investigator Award, American Society for Nutrition (ASN), 2013.

• Future Leader Research Award, International Life Sciences Institute (ILSI) North America. 2012.

• Outstanding Volunteer Award, Food Chemistry Division, Institute of Food Technologies (IFT), 2011 and 2012

• Louis and Elsa Thomsen Wisconsin Distinguished Fellowship Award, 2003-2004

• First place winner of Graduate Research Competition, Institute of Food Technologies (IFT), 2003.

 

Publications

Peer-reviewed Journal Publications (total of more than 240)

2019

  • Han, Y; Song, M; Gu, M; Ren, D; Zhu, X; Cao, X; Li, F; Wang, W; Cai, X; Yuan, B; Goulette, T; Zhang, G; Xiao, H., Dietary Intake of Whole Strawberry Inhibited Colonic Inflammation in Dextran-Sulfate-Sodium-Treated Mice via Restoring Immune Homeostasis and Alleviating Gut Microbiota Dysbiosis. Journal of agricultural and food chemistry. (Accepted)
  • Duan, S; Zhou, X; Xiao, H; Miao, J; Zhao, L., Characterization of Bacterial Microbiota in Tilapia Fillets Under Different Storage Temperatures. Journal of food science. (Accepted)
  • Sun, J; Qi, C; Zhu, H; Zhou, Q; Xiao, H; Le, G; Chen, D; Yu, R., lgA-Targeted Lactobacillus jensenii Modulated Gut Barrier and Microbiota in High-Fat Diet-Fed Mice. Frontiers in Microbiology. 2019, 10 (Accepted)
  • Zhou, H; Pandya, JK; Tan, Y; Liu, J; Peng, S; Muriel, Mundo JL; He, L; Xiao, H; McClements, DJ., Role of Mucin in Behavior of Food-Grade TiO2 Nanoparticles under Simulated Oral Conditions. Journal of agricultural and food chemistry. 2019, 67:5882-90.
  • Zhao, L; Wang, K; Li, W; Soteyome, T; Xiao, H; Hu, Z., Protective effects of polyphenolic extracts from longan seeds promote healing of deep second-degree burn in mice. Food & function. 2019, 10:1433-1443.
  • Zhang, Z; Xiao, H; Zhou, P., Allergenicity suppression of tropomyosin from Exopalaemon modestus by glycation with saccharides of different molecular sizes. Food chemistry. 2019, 288:268-275.
  • lmran, A; Butt, MS; Xiao, H; lmran, M; Rauf, A; Mubarak, MS; Ramadan, MF., Inhibitory effect of black tea (Camellia sinensis) theaflavins and thearubigins against HCT 116 colon cancer cells and HT 460 lung cancer cells. Journal of Food Biochemistry. 2019, 43:e12822.
  • Han, J; Gu, L; Zhang, R; Shang, W; Yan, J; McClements, D; Wu, H; Zhu, B; Xiao, H., Bioaccessibility and cellular uptake of r,-carotene in emulsion-based delivery systems using scallop (Patinopecten yessoensis) gonad protein isolates: effects of carrier oil. Food & Function. 2019, 10:49-60.
  • Zhang, Z.; Zhang, R.; Xiao, H.; Bhattacharya, K.; Bitounis, D.; Demokritou, P.; McClements, D. J., Development of a standardized food model for studying the impact of food matrix effects on the gastrointestinal fate and toxicity of ingested nanomaterials. Nanolmpact 2019, 13: 13-25.
  • Li, J.; Frederick, A-L. M.; Jin, Y.; Guo, C.; Xiao, H.; Wood, R. J., The prevention of a high dose of vitamin D or its combination with sulforaphane on intestinal inflammation and tumorigenesis in Apc1638N mice fed a high-fat diet. Mo/. Nutr. Food Res. (Accepted)
  • Cao, X.; Han, Y.; Li, F.; Li, Z.; McClements, D.J.; He, L.; Decker, E. A.; Xing, B.; Xiao, H., Impact of protein-nanoparticle interactions on gastrointestinal fate of ingested nanoparticles: Not just simple protein corona effects. Nanolmpact 2019, 13:37-43.
  • Yuan, X.; Xiao, J.; Liu, X.; McClements, D.J.; Cao, Y.; Xiao, H., The gastrointestinal behavior of emulsifiers used to formulate excipient emulsions impact the bioavailability of f3-carotene from spinach. Food Chem. 2019, 278:811-819.
  • Li, R.; Liu, F.; Yang, X.; Chen, L-q.; Wang, F.; Zhang, G-1.; Zhang, Q.; Zhang, L.; He, Y-x.; Li, Y-f.; Lai, P.; Chen, X-g.; Ye, M.; Xiao, H-t.; Xiao, H.*, Analysis of bisabolocurcumin ether (a terpene-conjugated curcuminoid) and three curcuminoids in Curcuma species from different regions by UPLC-ESI MS/MS and their in vitro anti-inflammatory activities. J. Funct. Foods 2019, 52: 186-95.
  • Zhang, Z.; Xiao, H.; Zhang, X.; Zhou, P., Conformation, allergenicity and human cell allergy sensitization of tropomyosin from Exopalaemon modestus:Effects of deglycosylation and Maillard reaction. Food Chem. 2019, 276: 520-527

2018

  • Ding, YP; Gao, ZL; Chen, BC; Rakariyatham, K; Suo, HY; Tong, HR; Xiao, H., The Effect of Different Treatments of (-)-Epigallocatechin-3-Gallate on Colorectal Carcinoma Cell Lines. Nutrition and cancer. 2018, 70:1126-36.
  • Wu, X.; Song, M.; Cai, X.;Neto, C.; Tata, A.; Han, Y.; Wang, Q.; Tang, Z.; Xiao, H.*, Chemopreventive Effects of Whole Cranberry (Vaccinium macrocarpon) on Colitis-Associated Colon Tumorigenesis. Mo/. Nutr. Food Res. 2018 e1800942
  • Ward, D.M.; Patras, A.; Kilonzo-Nthenge, A.; Yannam, S.K.; Pan, C.; Xiao, H.; Sasges, M., UV-C treatment on the safety of skim milk: effect on microbial inactivation and cytotoxicity evaluation. J. Food Process Eng. 2018 (DOI) - 10.1111/jfpe.12944
  • Sanidad, K. Z.; Xiao, H.; Zhang, G., Triclosan, a common antimicrobial ingredient, on gut microbiota and gut health. Gut Microbes 2018, DOI: 10.1080/19490976.2018.1546521
  • Sun, S.; Liu, F.; Liu, G.; Miao, J.; Xiao, H. ;Xiao, J.; Qiu, Z.; Luo, Z.; Tang, J.; Cao, Y., Effects of casein phosphopeptides on calcium absorption and metabolism bioactivity in vitro and in vivo. Food & Funct. 2018, 9(10):5220-5229
  • Yuan, X.; Liu, X.; McClements, D,J.; Cao, Y.; Xiao, H., Enhancement of phytochemical bioaccessibility from plant-based foods using excipient emulsions: impact of lipid type on carotenoid solubilization from spinach. Food & Funct. 2018, 9(8):4352-4365
  • Yang, H.; Wang, W.; Romano, K.A.; Gu, M.; Sanidad, K.Z.; Kim, D.; Yang, J.; Schmidt, B.; Panigrahy, D.; Pei, R.; Martin, D.A.; Ozay, E.I.; Wang, Y.;Song, M.; Bolling, B.W.; Xiao, H.; Minter, L.M.; Yang, G.Y.; Liu, Z.; Rey, F. E.; Zhang, G., A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice. Sci. Transl. Med. 2018,10(443) pii: eaan4116
  • Yang, Y.; Zhao, C.; Tian, G.; Lu, C.; Li, C.; Bao, Y.; Tang, Z.; McClements, D.J.; Xiao, H.; Zheng, J., Characterization of physical properties and electronic sensory analyses of citrus oil-based nanoemulsions. Food Res. Int. 2018, 109:149-158
  • Yang, X.; Dai, J.; Zhao, S.; Li, R.; Goulette, T.; Chen, X.; Xiao, H., Identification and characterization of a novel carboxylesterase from Phaseolus vulgaris for detection of organophosphate and carbamates pesticides. J. Sci. Food Agric. 2018, 98(13):5095-5104
  • Yang, X.; Dai, J.; Yang, L.; Ma, M.; Zhao, S.; Chen, X.; Xiao, H., Oxidation pretreatment by calcium hypochlorite to improve the sensitivity of enzyme inhibition-based detection of organophosphorus pesticides. J. Sci. Food Agric. 2018, 98(7):2624-2631
  • Sanidad, K.; Yang, H.; Wang, W.; Ozay, E.; Yang, J.; Gu, M.; Karner, M.; Zhang, J.; Kim, D.; Minter, L.; Xiao, H.; Zhang, G., Effects of consumer antimicrobials benzalkonium chloride, benzethonium chloride, and chloroxylenol on colonic inflammation and colitis-associated colon tumorigenesis in mice. Toxicol. Sci. 2018, 163(2):490-499
  • Vergne, M.J.; Patras, A.; Bhullar, M.S.; Shade, L. M.; Sasges, M.; Rakariyatham, K.; Pan, C.; Xiao, H., UV-C Irradiation on the Quality of Green Tea: Effect on Catechins, Antioxidant Activity, and Cytotoxicity. J. Food Sci. 2018, 83(5):1258-1264
  • Guo, S.; Wu, X.; Zheng, J.; Charoensinphon, N.; Dong, P.; Qiu, P.; Song, M.; Tang, Z.; Xiao, H., Anti-inflammatory effect of xanthomicrol, a major colonic metabolite of 5-demethyltangeretin. Food & Funct. 2018, 9(6):3104-3113
  • Yao, M.; Li, B.; Ye, H.; Huang, W.; Luo, Q.; Xiao, H.; McClements, D.J.; Li, L., Enhanced viability of probiotics (Pediococcus pentosaceus Li05) by encapsulation in microgels doped with inorganic nanoparticles. Food Hydrocolloids 2018, 83:246-252
  • Rakariyatham, K.; Wu, X.; Tang, Z.; Han, Y.; Want, Q.; Xiao, H., Synergism between Luteolin and Sulforaphane in Anti-inflammation. Food & Funct. 2018,9:5115-5123
  • Zhao, S.; Tian, G.; Zhao, C.; Li, C.; Bao, Y.; DiMarco-Crook, C.; Tang, Z.; Li, C.; McClements, D. J.; Xiao, H*.; Zheng, J., The stability of three different citrus oil-in-water emulsions abricated by spontaneous emulsification. Food Chem. 2018, 269:577-587
  • Hu, Q.; Yuan, B.; Xiao, H.*; Zhao, L.; Wu, X.; Rakarivatham, K.; Zhong, L.; Han, Y.; Muinde Kimatu, B.; Yang, W., Polyphenols-rich extract from Pleurotus eryngii with growth inhibitory of HCT116 colon cancer cells and anti-inflammatory function in RAW264.7 cells. Food & Funct. 2018, 1 :9(3):1601-11
  • Singh, M.; Patras, A.; Kilanzo-Nthenge, A.; Yannam, S.K.; Rakariyatham, K.; Pan, C.; Xiao, H.; Sasges, M., Microbial inactivation and cytotoxicity evaluation of UV irradiated coconut water in a novel continuous flow reactor. Food Res. Int. 2018 103:59-67
  • Zhang, Y.; Zhao, C.; Tian, G.; Lu, C.; Li, Y.; He, L.; Xiao, H.; Zheng, J., Simultaneous characterization of chemical structures and bioactivities of citrus-derived components using SERS barcodes. Food Chem. 2018, 240, 743-50.
  • Wu, X.; Song, M.; Qiu, P.; Li, F.; Wang, M.; Zheng, J.; Wang, Q.; Xu, F.; Xiao, H.*, A metabolite of nobiletin, 4'-demethylnobiletin and atorvastatin synergistically inhibits human colon cancer cell growth by inducing G0/G1 cell cycle arrest and apoptosis. Food & Funct. 2018, 9, 87-95

2017

  • DeLoid, G.M.; Wang, Y.; Kapronezai, K.; Lorente, L.R.; Zhang, R.; Pyrgiotakis, G.; Konduru, N. V.; Ericsson, M.; White, J.; Torre-Roche, R.D.; Xiao, H.; McClements, D. J.; Demokritou, P., An integrated methodology for assessing the impact of food matrix and gastrointestinal effects on the biokinetics and cellular toxicity of ingested engineered nanomaterials. Part. Fibre Toxicol. 2017, 14:40
  • Xu, M.; Tian, G.; Zhao, C.; Ahmad, A.; Zhang, H.; Bi, J.; Xiao, H.; Zheng, J., Infrared drying as a quick preparation method for dried tangerine peel. Int. J. Anal. Chem. 2017, 2017:6254793
  • Qi, C.; Li, Y.; Yu, R.Q.; Zhou, S.L.; Wang, X.G.; Le, G.W.; Jin, Q.Z.; Xiao, H.; Sun, J., Composition and immuno-stimulatory properties of extracellular DNA from mouse gut flora. World J. Gastroenterol. 2017, 23(44):7830-7839
  • Yang, Y.; Wang, X.; Zhao, C.; Tian, G.; Zhang, H.; Xiao, H.; He, L.; Zheng, J., Chemical mapping of essential oils, flavonoids and carotenoids in citrus peels by Raman microscopy. J. Food Sci. 2017, 82(12), 2840-46
  • You, X.; Einson, JE.; Lopez-Pena, CL.; Song, M.; Xiao, H.; McClements, D.J.; Sela, D.A., Food-grade cationic antimicrobial E-polylysine transiently alters the gut microbial community and predicted metagenome function in CD-1 mice. NPJ Science of Food 2017, 1 :8
  • Li, Q.; Liu, C.M.; DeLoid, G.M.; Pyrgiotakis, G.; Demokritou, P.; Zhang, R.; Xiao, H.; McClements, D.J., Potential impact of inorganic nanoparticles on macronutrient digestion: Titanium dioxide nanoparticles slightly reduce lipid digestion under simulated gastrointestinal conditions. Nanotoxicology2017, 11(9-10):1087-1101
  • McClements, D. J.; Xiao, H., Is nano safe in foods? Establishing the factors impacting the gastrointestinal fate and toxicity of organic and inorganic food- grade nanoparticles. NPJ Science of Food 2017, (2017): 1-6
  • Ding, Y.; Chen, B.; Gao, Z.; Suo, H.; Xiao, H.*, Pre-treated theaflavin-3,3'-digallate has a higher inhibitory effect on the HCT116 cell line. Food Nutr. Res. 2017, 61: 1, 1400340
  • McClements, D. J.; Xiao, H., Designing Food Structure and Composition to Enhance Nutraceutical Bioactivity to Support Cancer Inhibition. Semin. Cancer Biol. 2017, 46, 215-26
  • Ren, D.; Qi, J.; Xie, A.; Jia, M.; Yang, X.; Xiao, H.*, Encapsulation in lysozyme/A. sphaerocephala krasch polysaccharide nanoparticles increases stability and bioefficacy of curcumin. J. Functional Foods 2017, 38(A), 100-9
  • Yuan, B.; Ma, N.; Zhao, L.; Zhao, E.; Gao, Z.; Wang, W.; Song, M.; Zhang, G.; Hu, Q.; Xiao, H.*, In vitro and in vivo inhibitory effects of a Pleurotus eryngii protein on colon cancer cells. Food Funct. 2017, 8(10):3553-62
  • Cao, Y.; Miao, J.; Liu, G.; Luo, Z.; Xia, Z.; Liu, F.; Yao, M.; Cao, X.; Sun, S.; Lin, Y.; Lan, Y.; Xiao, H.*, Bioactive Peptides Isolated from Casein Phosphopeptides Enhance Calcium and Magnesium Uptake in Caco-2 Cell Monolayers. J. Agri. Food Chem. 2017, 65, 2307-14
  • Yang, Y.; Zhao C.; Tian, G.; Lu. C.; Zhao, S.; Bao, Y.; McClements, D.J.; Xiao, H.*; Zheng, J., Effects of preheating and storage temperatures on aroma profile and physical properties of citrus-oil emulsions. J. Agric. Food Chem. 2017, 65(35), 7781-89
  • Yao, M.; Wu, J.; Li, B.; Xiao, H.; McClements, D.; Li, L., Microencapsulation of Lactobacil/us salivarious Li01 for enhanced storage viability and targeted delivery to gut microbiota. Food Hydrocolloids 2017, 72, 228-36
  • McClements, D.J.; Xiao, H.; Demokritou, P., Physicochemical and colloidal aspects of food matrix effects on gastrointestinal fate of ingested inorganic nanoparticles. Adv. Colloid Interface Sci. 2017, 246, 165-80
  • Yang, H.; Du, Z.; Wang, W.; Song, M.; Sanidad, K.; Sukamtoh, E.; Zheng, J.; Tian, L.; Xiao, H.; Liu, Z.; Zhang , G., Structure and activity relationship of curcumin: role of methoxy group in anti-inflammatory and anti-colitis effects of curcumin. J. Agric. Food Chem. 2017, 65, (22), 4509-15
  • Yang, Y.; Xiao, H.; McClements, D. J., Impact of Lipid Phase on Bioavailability of Vitamin E in Emulsion-based Delivery Systems: Relative Importance of Bioaccessibility, Absorption, and Transformation. J. Agric. Food Chem. 2017, 65, (19), 3946-55
  • Yuan, B.; Zhao, L.; Rakariyatham, K.; Han, Y.; Gao, Z.; Muinde, B.; Hu, Q.; Xiao, H.*, Isolation of a novel bioactive protein from an edible mushroom Pleurotus eryngii and its anti­inflammatory potential. Food Funct. 2017, 8, 2175-83
  • Zhao, B.; Cao, X.; De La Torre-Roche, R.; Tan, C.; Yang, T.; White, J. C.; Xiao, H.; He, L., A green, facile, and rapid method for microextraction and Raman detection of titanium dioxide nanoparticles from milk powder. RSC Adv. 2017, 7, 21380-88
  • Song, M.; Lopez-Pena, C. L.; McClements, D. J.; Decker, E. A.; Xiao, H.*, Safety evaluation and lipid-lowering effects of food-grade biopolymer complexes (£-polylysine-pectin) in mice fed a high-fat diet. Food Funct. 2017, 8, 1822 -29
  • Hao, X.; Xiao, H.*; Ju, J.; Lee, M.-J.; Lambert, J.D.; Yang, C.S., Green tea polyphenols inhibit colorectal tumorigenesis in azoxymethane-treated F344 rats. Nutr. Cancer 2017, 69:4, 623-631 (* co-first author)
  • Rafiq, S.; Huma, N.; Pasha, l.;Shahid, M.; Xiao, H., Angiotensin-converting enzyme-inhibitory and antithrombotic activities of soluble peptide extracts from buffalo and cow milk Cheddar cheeses. Int. J. Dairy Technol. 2017, 70, (3), 380-8.
  • Wu, X.; Song, M.; Qiu, P.; Rakaruyatham, K.; Li, F.; Gao, Z.; Wang, M.; Xu, F.; Zheng, J.; Xiao, H.*, Synergistic chemopreventive effects of nobiletin and atorvastatin on colon carcinogenesis. Carcinogenesis 2017, 38, (4), 455-64.
  • Song, M.; Wu, X.; Charoensinphon, N.; Wang, M.; Zheng, J.; Gao, Z.;Xu, F.; Li, F.; Zhou J.; Xiao, H.*, Dietary 5-Demethylnobiletin Inhibits Cigarette Carcinogen-Induced Lung Tumorigenesis in Mice. Food Funct. 2017, 8, 954-63.
  • Chen, X.; Wu, X.; Ouyang, W.; Gu, M.; Gao, Z.; Song, M.; Chen, Y.; Lin, Y.; Cao, Y.; Xiao, H.*, Novel ent-kaurane diterpenoid from Rubus corchorifolius L.f inhibits human colon cancer cell growth via inducing cell cycle arrest and apoptosis. J. Agric. Food Chem. 2017, 65, (8), 1566-73
  • Yang, Y.; Zhao, C.; Chen, J.; Tian, G.; McClements, D.; Xiao, H.*; Zheng, J., Encapsulation of Polymethoxyflavones in Citrus Oil Emulsion-Based Delivery Systems. J. Agri. Food Chem. 2017, 65, 1732-39
  • Qiu, P.; Cui, Y.; Xiao, H.; Han, Z.; Ma, H.; Tang, Y.; Xu, H.; Zhang, L., 5-Hydroxy polymethoxyflavones inhibit glycosaminoglycan biosynthesis in lung and colon cancer cells. J. Fune. Foods,2017,30,39-47
  • Han, K.; Yao, Y.; Dong, S.; Sun, J.; Xiao, H.; Wu, H.; Zeng, M., Chemical characterization of the glycated myofibrillar proteins from grass carp (Ctenopharyngodon idella) and its impacts on the human gut microbiota in vitro fermentation. Food Funct. 2017, 8,(3), 1184-94
  • Chen, X.; Gao, Z.; Song, M.; Ouyang, W.; Wu, X.; Chen, Y.; Zhou, L.; Dixon, W.; Cai X.; Zjou S.; Tang, Z.; Xiao, H.*, Identification of terpenoids from Rubus corchorifolius L.f. leaves and their anti-proliferative effects on human cancer cells. Food Funct. 2017, 8, (3), 1052-60
  • Chen, J.; Li, F.; Li, Z.; McClements, D.; Xiao, H.*, Encapsulation of carotenoids in emulsion­based delivery systems: Enhancement of B-carotene water-dispersibility and chemical stability. Food Hydrocolloids 2017, 69, 49-55
  • Wu, X.; Song, M.; Gao, Z.; Sun, Y.; Wang, M.; Li, F.; Zheng, J.; Xiao, H.*, Nobiletin and its colonic metabolites suppress colitis-associated colon carcinogenesis by down-regulating iNOS, inducing antioxidative enzymes and arresting cell cycle progression. J. Nutr. Biochem. 2017, 42, 17-25
  • Yao, M.; McClements, D.J.; Zhao, F.; Craig, R.; Xiao, H.*, Controlling the gastrointestinal fate of nutraceutical and pharmaceutical-enriched lipid nanoparticles: From mixed micelles to chylomicrons. Nanolmpact 2017, 5, 13-21
  • Xia, Z.; McClements, D.J.; Xiao, H.,* Influence of Lipid Content in a Corn Oil Preparation on the Bioaccessibility of B-Carotene: A Comparison of Low-Fat and High-Fat Samples. Food Chem. 2017, 82,373-79

2016

  • Sun, Y.; Wu, X.; Cai, X.; Song, M.; Zheng, J.; Pan, C.; Qiu, P.; Zhang, L.; Zhou, S.; Tang, Z.; Xiao, H.*, Identification of pinostilbene as a major colonic metabolite of pterostilbene and its inhibitory effects on colon cancer cells. Mo/. Nutr. Food Res. 2016, 60(9), 1924-32.
  • Cao, X.; Ma, C.; Gao, Z.; Zheng, J.; He, L.; McClements, D.; Xiao, H.*, Characterization of the interactions between titanium dioxide nanoparticles and polymethoxyflavones using surface-enhanced Raman spectroscopy. J. Agric. Food Chem. 2016, 64, (49), 9436-41.
  • Liu, X.; Song, M.; Gao, Z.; Cai, X.; Dixon, W.; Chen, X.; Cao, Y.; Xiao, H.*, Stereoisomers of astaxanthin inhibit human colon cancer cell growth by inducing G2/M cell cycle arrest and apoptosis. J. Agric. Food Chem. 2016, 64, (41 ), 7750-59.
  • Liu, X.; Luo, Q.; Cao, Y.; Goulette, T.; Liu, X.; Xiao, H.*, Mechanism of different stereoisomeric astaxanthin in resistance to oxidative stress in Caenorhabditis elegans. J. Food Sci. 2016, 81(9), H2280-87.
  • Hao, X.; Xiao, H.; Ju, J.; Hewitt, S.M.; Morse, H.C., Decreased expression of retinoid X receptors during human and azoxymethane-induced colorectal carcinogenesis in the rat. Anticancer Research 2016, 36, 2659-64.
  • Huang, X.; Dai, Y.; Cai, J.; Zhong, N.; Xiao, H.; McClements, D. J., Resveratrol encapsulation in core-shell biopolymer nanoparticles: Impact on antioxidant and anticancer activities. Food Hydrocolloids 2016, 64, 157-65.
  • Maio, J.; Liu, G.; Ke, C.; Fan, W.; Li, C.; Chen, Y.; Dixon, W.; Song, M.; Cao, Y.; Xiao, H.*, Inhibitory effects of a novel antimicrobial peptide from kefir against Escherichia coli. Food Control, 2016, 65, 63-72.
  • Islam, M.S.; Patras A.; Pokharel, 8.; Vergne, M.J.; Sasges, M.; Begum, A.; Rakariyatham, K.; Pan, C.; Xiao, H., Effect of UV irradiation on nutritional quality and cytotoxicity of apple juice. J. Agric. Food Chem. 2016, 64, (41), 7812-22.
  • Zou, L.; Zhang, Z.; Zhang, R.; Liu, W.; Liu, C.; Xiao, H.; McClements, D. J., Encapsulation of protein nanoparticles within alginate microparticles: Impact of pH and ionic strength on functional performance. J. Food Eng. 2016, 178, 81-89.Zhang, H.; Zheng, J.; Liu, A.; Xiao, H.*; He, L., Label-free imaging and characterization of cancer cell responses to polymethoxyflavones using Raman microscopy. J. Agric. Food Chem., 2016, 64 (51), 9708-13.
  • Zhang, R.; Zhang, Z.; Zou, L.; Xiao, H.; Zhang, G.; Decker, E. A.; McClements, D. J., Impact of lipid content on the ability of excipient emulsions to increase carotenoid bioaccessibility from natural sources (raw and cooked carrots). Food Biophys. 2016, 11, (1), 71-80.
  • Zhang, R.; Zhang, Z.; Zou, L.; Xiao, H.; Zhang, G.; Decker, E. A.; McClements, D. J., Enhancement of carotenoid bioaccessibility from carrots using excipient emulsions: influence of particle size of digestible lipid droplets. Food Funct. 2016, 7, (1), 93-103.
  • Zou, L.; Zheng, B.; Zhang, R.; Zhang, Z.; Liu, W.; Liu, C.; Xiao, H.; McClements, D. J., Food­grade nanoparticles for encapsulation, protection and delivery of curcumin: comparison of lipid, protein, and phospholipid nanoparticles under simulated gastrointestinal conditions. RSC Adv 2016, 6, 3126-36.
  • Wang, P.; Li, Y.; Xiao, H.; Shi, Y.; Le, G. W.; Sun, J., Isolation of Lactobacillus reuteri from Payer's patches and their effects on slgA production and gut microbiota diversity. Mo/. Nutr. Food Res. 2016, 60, 2020-30.
  • Sun, J.; Qiao, Y.; Qi, C.; Jiang, W.; Xiao, H.; Shi, Y.; Le, G. W., High-fat-diet-induced obesity is associated with decreased antiinflammatory Lactobacillus reuteri sensitive to oxidative stress in mouse Payer's patches. Nutrition 2016, 32, (2), 265-72.
  • Song, M.; Charoensinphon, N.; Wu, X.; Zheng, J.; Gao, Z.; Xu, F.; Wang, M.; Xiao, H.*, Inhibitory effects of metabolites of 5-demethylnobiletin on human nonsmall cell lung cancer cells. J. Agric. Food Chem. 2016, 64, (24 ), 4943-49.
  • Zou, L.; Zheng, B.; Zhang, R.; Zhang, Z.; Liu, W.; Liu, C.; Zhang, G.; Xiao, H.; McClements, D. J., Influence of lipid phase composition of excipient emulsions on curcumin solubility, stability, and bioaccessibility. Food Biophys. 2016, 11, (3), 213-25.
  • Sanidad, K. Z.; Sukamtoh, E.; Wang, W.; Du, Z.; Florio, E.; He, L.; Xiao, H.; Decker, E. A.; Zhang, G., Oxidative conversion mediates antiproliferative effects of tert-butylhydroquinone: structure and activity relationship study. J. Agric. Food Chem. 2016, 64, (19), 3743-8.
  • Miao, J.; Zhou, J.; Liu, G.; Chen, F.; Chen, Y.; Gao, X.; Dixon, W.; Song, M.; Xiao, H.*; Cao, Y., Membrane disruption and DNA binding of Staphylococcus aureus cell induced by a novel antimicrobial peptide produced by Lactobacillus paracasei subsp. tolerans FX-6. Food Contro/2016, 59, 609-13.
  • McClements, D. J.; Saliva-Trujillo, L.; Zhang, R.; Zhang, Z.; Zou, L.; Yao, M.; Xiao, H., Boosting the bioavailability of hydrophobic nutrients, vitamins, and nutraceuticals in natural products using excipient emulsions. Food Res. Int. 2016, 88, Part A, 140-152.
  • Ma, C.; Xiao, H.*; He, L., Surface-enhanced Raman scattering characterization of monohydroxylated polymethoxyflavones. J. Raman Spectrosc. 2016, 47, (8), 901-7.
  • Lopez-Pena, C. L.; Zheng, 8.; Sela, D. A.; Decker, E. A.; Xiao, H.; McClements, D. J., Impact of epsilon-polylysine and pectin on the potential gastrointestinal fate of emulsified lipids: In vitro mouth, stomach and small intestine model. Food Chem. 2016, 192, 857-64.
  • Liu, X.; McClements, D. J.; Cao, Y.; Xiao, H.*, Chemical and physical stability of astaxanthin­enriched emulsion-based delivery systems. Food Biophys. 2016, 11, (3), 302-10.
  • Liu, X.; Luo, Q.; Rakariyatham, K.; Cao, Y.; Goulette, T.; Liu, X.; Xiao, H.*, Antioxidation and anti-ageing activities of different stereoisomeric astaxanthin in vitro and in vivo. J. Functional Foods 2016, 25, 50-61.
  • Huang, X.; Huang, X.; Gong, Y.; Xiao, H.; McClements, D.J.; Hu, K., Enhancement of curcumin water dispersibility and antioxidant activity using core-shell protein-polysaccharide nanoparticles. Food Res. Int. 2016, 87, 1-9
  • McClements, D. J.; DeLoid, G.; Pyrgiotakis, G.; Shatkin, J.A.; Xiao, H.; Demokritou, P., The role of the food matrix and gastrointestinal tract in the assessment of biological properties of ingested engineered nanomaterials (iENMs): State of the science and knowledge gaps. Nanolmpact 2016, 3-4, 47-57.
  • Liu, X.; Bi, J.; Xiao, H.; McClements, D. J., Enhancement of nutraceutical bioavailability using excipient nanoemulsions: role of lipid digestion products on bioaccessibility of carotenoids and phenolics from mangoes. J. Food Sci. 2016, 81, (3), N754-61.
  • Islam, M. S.; Patras, A.; Pokharel, B.; Wu, Y.; Vergne, M. J.; Shade, L.; Xiao, H.; Sasges, M., UV-C irradiation as an alternative disinfection technique: Study of its effect on polyphenols and antioxidant activity of apple juice. lnnov. Food Sci. Emerg. Technol. 2016, 34, 344-51.
  • Zou, L.; Zheng, B.; Zhang, R.; Zhang, Z.; Liu, W.; Liu, C.; Xiao, H.; McClements, D. J., Enhancing the bioaccessibility of hydrophobic bioactive agents using mixed colloidal dispersions: Curcumin-loaded zein nanoparticles plus digestible lipid nanoparticles. Food Res. Int. 2016, 81, 74-82.
  • Zou, L.; Zheng, B.; Zhang, R.; Zhang, Z.; Liu, W.; Liu, C.; Xiao, H.; McClements, D.J., Food matrix effects on nutraceutical bioavailability: Impact of protein on curcumin bioaccessibility and transformation in nanoemulsion delivery systems and excipient nanoemulsions. Food Biophys. 2016, 11, (2), 142-153.
  • Funaro, A.; Wu, X.; Song, M.; Zheng, J.; Guo, S.; Rakariyatham, K.; Rodriguez-Estrada, M. T.; Xiao, H.*, Enhanced anti-inflammatory activities by the combination of luteolin and tangeretin. J. Food Sci. 2016, 81, (5), H1320-7.

2015

  • Zou, L.; Zheng, B.; Liu, W.; Liu, C.; Xiao, H.; McClements, D. J., Enhancing nutraceutical bioavailability using excipient emulsions: Influence of lipid droplet size on solubility and bioaccessibility of powdered curcumin. J. Functional Foods 2015, 15, 72-83.
  • Zou, L.; Liu, W.; Liu, C.; Xiao, H.; McClements, D. J., Utilizing food matrix effects to enhance nutraceutical bioavailability: increase of curcumin bioaccessibility using excipient emulsions. J. Agric. Food Chem. 2015, 63, (7), 2052-62.
  • Zou, L.; Liu, W.; Liu, C.; Xiao, H.; McClements, D. J., Designing excipient emulsions to increase nutraceutical bioavailability: emulsifier type influences curcumin stability and bioaccessibility by altering gastrointestinal fate. Food Funct 2015, 6, (8), 2475-86.
  • Zheng, J.; Bi, J.; Johnson, D.; Sun, Y.; Song, M.; Qiu, P.; Dong, P.; Decker, E.; Xiao, H.*, Analysis of 10 metabolites of polymethoxyflavones with high sensitivity by electrochemical detection in high-performance liquid chromatography. J. Agric. Food Chem. 2015, 63, (2), 509- 16.
  • Zhang, R.; Zhang, Z.; Zou, L.; Xiao, H.; Zhang, G.; Decker, E. A.; McClements, D. J., Enhancing nutraceutical bioavailability from raw and cooked vegetables using excipient emulsions: Influence of lipid type on carotenoid bioaccessibility from carrots. J. Agric. Food Chem. 2015, 63, (48), 10508-17.
  • Yao, M.; McClements, D. J.; Xiao, H.*, Improving oral bioavailability of nutraceuticals by engineered nanoparticle-based delivery systems. Curr. Opin. Food Sci. 2015, 2, 14-19.
  • Yao, M.; He, L.; McClements, D. J.; Xiao, H.*, Uptake of gold nanoparticles by intestinal epithelial cells: Impact of particle size on their absorption, accumulation, and toxicity. J. Agric. Food Chem. 2015, 63, (36), 8044-9.
  • Yang, Y.; Decker, E. A.; Xiao, H.; McClements, D. J., Enhancing vitamin E bioaccessibility: factors impacting solubilization and hydrolysis of alpha-tocopherol acetate encapsulated in emulsion-based delivery systems. Food Funct. 2015, 6, (1), 84-97.
  • Xia, Z.; McClements, D. J.; Xiao, H.*, Influence of physical state of beta-carotene (crystallized versus solubilized) on bioaccessibility. J. Agric. Food Chem. 2015, 63, (3), 990-7.
  • Wu, X.; Song, M.; Wang, M.; Zheng, J.; Gao, Z.; Xu, F.; Zhang, G.; Xiao, H.*, Chemopreventive effects of nobiletin and its colonic metabolites on colon carcinogenesis. Mo/. Nutr Food Res. 2015, 59, (12), 2383-94.
  • McClements, D.J.; Zou, L.; Zhang, R.; Salvia-Trujillo, L.; Kumosani, T.; Xiao, H., Enhancing nutraceutical performance using excipient foods: Designing food structures and compositions to increase bioavailability. Compr. Rev. Food Sci. Food Saf. 2015, 14,(6), 824-47.
  • Wu, X.; Song, M.; Rakariyatham, K.; Zheng, J.; Wang, M.; Xu, F.; Gao, Z.; Xiao, H.*, Inhibitory effects of 4'-demethylnobiletin, a metabolite of nobiletin, on 12-O-Tetradecanoylphorbol-13-acetate {TPA)-induced inflammation in mouse ears. J. Agric. Food Chem. 2015, 63, (51 ), 10921-7.
  • Wu, X.; Song, M.; Rakariyatham, K.; Zheng, J.; Guo, S.; Tang, Z.; Zhou, S.; Xiao, H.*, Anti­inflammatory effects of 4'-demethylnobiletin, a major metabolite of nobiletin. J. Functional Foods 2015, 19, (Pt A), 278-87.
  • Wiriyaphan, C.; Xiao, H.; Decker, E. A.; Yongsawatdigul, J., Chemical and cellular antioxidative properties of threadfin bream (Nemipterus spp.) surimi byproduct hydrolysates fractionated by ultrafiltration. Food Chem. 2015, 167, 7-15.
  • Wang, W.; Sukamtoh, E.; Xiao, H.; Zhang, G., Curcumin inhibits lymphangiogenesis in vitro and in vivo. Mo/. Nutr. Food Res. 2015, 59, (12), 2345-54.
  • Sung, M.-R.; Xiao, H.; Decker, E. A.; McClements, D. J., Fabrication, characterization and properties of filled hydrogel particles formed by the emulsion-template method. J. Food Eng. 2015, 155, 16-21.
  • Sun, Y.; Xia, Z.; Zheng, J.; Qiu, P.; Zhang, L.; McClements, D. J.; Xiao, H.*, Nanoemulsion­based delivery systems for nutraceuticals: Influence of carrier oil type on bioavailability of pterostilbene. J. Functional Foods 2015, 13, 61-70.
  • Miao, J.; Xu, M.; Guo, H.; He, L.; Gao, X.; DiMarco-Crook, C.; Xiao, H.*; Cao, Y., Optimization of culture conditions for the production of antimicrobial substances by probiotic Lactobacillus paracasei subsp. Tolerans FX-6. J. Functional Foods 2015, 18, Part A, 244-253.
  • Miao, J.; Chen, F.; Duan, S.; Gao, X.; Liu, G.; Chen, Y.; Dixon, W.; Xiao, H.*; Cao, Y., iTRAQ­based quantitative proteomic analysis of the antimicrobial mechanism of peptide F1 against Escherichia coli. J. Agric. Food Chem. 2015, 63, (32), 7190-7.
  • McClements, D. J.; Li, F.; Xiao, H., The nutraceutical bioavailability classification scheme: Classifying nutraceuticals according to factors limiting their oral bioavailability. Annu. Rev. Food Sci. Technol. 2015, 6, 299-327.
  • Lopez-Pena, C. L.; Song, M.; Xiao, H.; Decker, E. A.; McClements, D. J., Potential impact of biopolymers (E-polylysine and/or pectin) on gastrointestinal fate of foods: In vitro study. Food Res. Int. 2015, 76, Part 3, 769-776.
  • Liu, X.; Bi, J.; Xiao, H.; McClements, D. J., Increasing carotenoid bioaccessibility from yellow peppers using excipient emulsions: Impact of lipid type and thermal processing. J. Agric. Food Chem. 2015, 63, (38), 8534-43.
  • Hu, K.; Huang, X.; Gao, Y.; Huang, X.; Xiao, H.; McClements, D. J., Core-shell biopolymer nanoparticle delivery systems: Synthesis and characterization of curcumin fortified zein­pectin nanoparticles. Food Chem. 2015, 182, 275- 281.
  • DiMarco-Crook, C.; Xiao, H.*, Diet-based strategies for cancer chemoprevention: the role of combination regimens using dietary bioactive components. Annu. Rev. Food Sci. Technol. 2015, 6, 505-26.
  • Chen, J.; Zheng, J.; Decker, E. A.; McClements, D. J.; Xiao, H.*, Improving nutraceutical bioavailability using mixed colloidal delivery systems: lipid nanoparticles increase tangeretin bioaccessibility and absorption from tangeretin-loaded zein nanoparticles. RSC Advances 2015, 5, (90), 73892-900.
  • Chen, J.; Song, M.; Wu, X.; Zheng, J.; He, L.; McClements, D. J.; Decker, E.; Xiao, H.*, Direct fluorescent detection of a polymethoxyflavone in cell culture and mouse tissue. J. Agric. Food Chem. 2015, 63, (49), 10620-7.
  • Blumberg, J. B.; Bolling, B. W.; Chen, C. Y. O.; Xiao, H., Review and perspective on the composition and safety of green tea extracts. European J. Nutr. Food Saf. 2015, 5, ( 1 ), 1-31.
  • McClements DJ, Trujillo LS, zou L, Zhang Z, Zhang R, et al. Designing excipient foods to improve oral bioavailability of nutraceuticals. INFORM. 2015; 26(6):351-355.

2014

  •  
  • Zheng, J.; Li, Y.; Song, M.; Fang, X.; Cao, Y.; McClements, D. J.; Xiao, H.*, Improving intracellular uptake of 5-demethyltangeretin by food grade nanoemulsions. Food Res. Int. 2014, 62, 98-103.
  • Zhang, W.; Xiao, H.; Parkin, K. L., Apoptosis in MCF-7 breast cancer cells induced by S­alkenylmercaptocysteine (CySSR) species derived from Allium tissues in combination with sodium selenite. Food Chem. Toxicol. 2014, 68, 1-10.
  • Yao, M.; Xiao, H.; McClements, D. J., Delivery of lipophilic bioactives: assembly, disassembly, and reassembly of lipid nanoparticles. Annu Rev Food Sci Technol. 2014, 5, 53-81.
  • McClements, D. J.; Xiao, H., Excipient foods: designing food matrices that improve the oral bioavailability of pharmaceuticals and nutraceuticals. Food Funct. 2014, 5, (7), 1320-33.
  • Cho, H. T.; Salvia-Trujillo, L.; Kim, J.; Park, Y.; Xiao, H.; McClements, D. J., Droplet size and composition of nutraceutical nanoemulsions influences bioavailability of long chain fatty acids and Coenzyme Q10. Food Chem. 2014, 156, 117-22.
  • Chen, J.; Zheng, J.; McClements, D. J.; Xiao, H.*, Tangeretin-loaded protein nanoparticles fabricated from zein/beta-lactoglobulin: preparation, characterization, and functional performance. Food Chem. 2014, 158, 466-72.
  • Butt, M. S.; lmran, A.; Sharif, M. K.; Ahmad, R. S.; Xiao, H.; lmran, M.; Rsool, H. A., Black tea polyphenols: a mechanistic treatise. Grit. Rev. Food Sci. Nutr. 2014, 54, (8), 1002-11.

2013

  • Zheng, J.; Song, M.; Dong, P.; Qiu, P.; Guo, S.; Zhong, Z.; Li, S.; Ho, C. T.; Xiao, H.*, Identification of novel bioactive metabolites of 5-demethylnobiletin in mice. Mo/. Nutr. Food Res. 2013, 57, (11), 1999-2007.
  • Zheng, J.; Fang, X.; Cao, Y.; Xiao, H.*; He, L., Monitoring the chemical production of citrus­derived bioactive 5-demethylnobiletin using surface-enhanced Raman spectroscopy. J. Agric. Food Chem. 2013, 61, (34 ), 8079-83.
  • Zheng, J.; Fang, X.; Xiao, H.; He, L., Rapid quantification of nobiletin and tangeretin in citrus peel extractions by Raman spectroscopy. J. Food Processing & Beverages. 2013, 1, ( 1 ), 4.
  • Zhang, G.; Nitteranon, V.; Guo, S.; Qiu, P.; Wu, X.; Li, F.; Xiao, H.; Hu, Q.; Parkin, K. L., Organoselenium compounds modulate extracellular redox by induction of extracellular cysteine and cell surface thioredoxin reductase. Chem. Res. Toxicol. 2013, 26, (3), 456-64.
  • Yao, M.; Chen, J.; Zheng, J.; Song, M.; McClements, D. J.; Xiao, H.*, Enhanced lymphatic transport of bioactive lipids: cell culture study of polymethoxyflavone incorporation into chylomicrons. Food Funct. 2013, 4, (11), 1662-7.
  • Rao, J.; Decker, E. A.; Xiao, H.; McClements, D. J., Nutraceutical nanoemulsions: influence of carrier oil composition (digestible versus indigestible oil) on beta-carotene bioavailability. J. Sci. Food Agr. 2013, 93, (13), 3175-83.
  • Qian, C.; Decker, E. A.; Xiao, H.; McClements, D. J., Impact of lipid nanoparticle physical state on particle aggregation and f3-carotene degradation: Potential limitations of solid lipid nanoparticles. Food Res. Int. 2013, 52, (1 ), 342-9.
  • Pool, H.; Mendoza, S.; Xiao, H.; McClements, D. J., Encapsulation and release of hydrophobic bioactive components in nanoemulsion-based delivery systems: impact of physical form on quercetin bioaccessibility. Food Funct. 2013, 4, (1), 162-74.
  • Naruemon, M.; Romance, S.; Cheunjit, P.; Xiao, H.; Mclandsborough, L.A.; Pawadee, M., Influence of additives on Saccharomyces cerevisiae f3-glucan production. Int. Food Res. J.            2013, 20, (4 ), 1953-9.
  • Mao, Y.; Dubot, M.; Xiao, H.; McClements, D. J., lnterfacial engineering using mixed protein systems: emulsion-based delivery systems for encapsulation and stabilization of beta-carotene. J. Agric. Food Chem. 2013, 61, (21), 5163-9.
  • He, L.; Zheng, J.; Labuza, T. P.; Xiao, H., A surface enhanced Raman spectroscopic study of interactions between casein and polymethoxyflavones. J. Raman Spectrosc. 2013, 44, (4 ), 531-535.
  • Charoensinphon, N.; Qiu, P.; Dong, P.; Zheng, J.; Ngauv, P.; Cao, Y.; Li, S.; Ho, C. T.; Xiao, H.*, 5-demethyltangeretin inhibits human nonsmall cell lung cancer cell growth by inducing G2/M cell cycle arrest and apoptosis. Mo/. Nutr Food Res. 2013, 57, (12), 2103-11.

2012

  • Qian, C.; Decker, E. A.; Xiao, H.; McClements, D. J., Solid Lipid Nanoparticles: Effect of Carrier Oil and Emulsifier Type on Phase Behavior and Physical Stability. JAOCS 2012, 89, (1), 17-28.
  • Qian, C.; Decker, E. A.; Xiao, H.; McClements, D. J., Inhibition of beta-carotene degradation in oil-in-water nanoemulsions: influence of oil-soluble and water-soluble antioxidants. Food Chem. 2012, 135, (3), 1036-43.
  • Qian, C.; Decker, E. A.; Xiao, H.; McClements, D. J., Nanoemulsion delivery systems: influence of carrier oil on beta-carotene bioaccessibility. Food Chem 2012, 135, (3), 1440-7.
  • Qian, C.; Decker, E. A.; Xiao, H.; McClements, D. J., Physical and chemical stability of 13-carotene-enriched nanoemulsions: Influence of pH, ionic strength, temperature, and emulsifier type. Food Chem. 2012, 132, (3), 1221-1229.
  • Mongkontanawat, N.; Sanguandeekul, R.; Phakitchaiwattana, C.; Xiao, H.; McLandsborough, L.; Methacanon, P., Effect of three additives on the cell morphology and 13-glucan production in Saccharomyces cerevisiae. RJPBCS 2012, 2, (4), 283-295.
  • McClements, D. J.; Xiao, H., Potential biological fate of ingested nanoemulsions: influence of particle characteristics. Food Funct. 2012, 3, (3), 202-20.
  • Li, Y.; Zheng, J.; Xiao, H.; McClements, D. J., Nanoemulsion-based delivery systems for poorly water-soluble bioactive compounds: Influence of formulation parameters on polymethoxyflavone crystallization. Food Hydrocolloids 2012, 27, (2), 517-28.
  • Li, Y.; Xiao, H.; McClements, D. J., Encapsulation and delivery of crystalline hydrophobic nutraceuticals using nanoemulsions: Factors affecting polymethoxyflavone solubility. Food Biophys. 2012, 7, (4), 341-353.
  • Guo, S.; Qiu, P.; Xu, G.; Wu, X.; Dong, P.; Yang, G.; Zheng, J.; McClements, D. J.; Xiao, H.*, Synergistic anti-inflammatory effects of nobiletin and sulforaphane in lipopolysaccharide­stimulated RAW 264.7 cells. J. Agric. Food Chem. 2012, 60, (9), 2157-64.
  • Ahmed, K.; Li, Y.; McClements, D. J.; Xiao, H.*, Nanoemulsion- and emulsion- based delivery systems for curcumin: Encapsulation and release properties. Food Chem. 2012, 132, (2), 799- 807.
  • Zhao, L.; Guo, L.; Xiao, H.; Zheng, L.; Wang, Y.; Lin, J., Purification and Characterization of the Recombinant Multifunctional Cellulase from Volvariella volvacea. Food Biotechnology, 2012, 26, 164-179.

2011

  • Qiu, P.; Guan, H.; Dong, P.; Li, S.; Ho, C. T.; Pan, M. H.; McClements, D. J.; Xiao, H.*, The p53-, Bax- and p21-dependent inhibition of colon cancer cell growth by 5-hydroxy polymethoxyflavones. Mo/. Nutr. Food Res. 2011, 55, (4), 613-22.
  • Qiu, P.; Guan, H.; Dong, P.; Guo, S.; Zheng, J.; Li, S.; Chen, Y.; Ho, C. T.; Pan, M. H.; McClements, D. J.; Xiao, H.*, The inhibitory effects of 5-hydroxy-3,6,7,8,3',4'­hexamethoxyflavone on human colon cancer cells. Mo/. Nutr. Food Res. 2011, 55, (10), 1523-32.
  • Qian, C.; Decker, E. A.; Xiao, H.; McClements, D. J., Comparison of Biopolymer Emulsifier Performance in Formation and Stabilization of Orange Oil-in-Water Emulsions. JAOCS 2011, 88, (1), 47-55.
  • Nutakul, W.; Sobers, H. S.; Qiu, P.; Dong, P.; Decker, E. A.; McClements, D. J.; Xiao, H.*, Inhibitory effects of resveratrol and pterostilbene on human colon cancer cells: a side-by-side comparison. J. Agric. Food Chem. 2011, 59, (20), 10964-70.
  • Li, Y.; Hu, M.; Du, Y.; Xiao, H.; McClements, D. J., Control of lipase digestibility of emulsified lipids by encapsulation within calcium alginate beads. Food Hydrocolloids 2011, 25, (1 ), 122-130.
  • Lai, C. S.; Tsai, M. L.; Cheng, A. C.; Li, S.; Lo, C. Y.; Wang, Y.; Xiao, H.; Ho, C. T.; Wang, Y. J.; Pan, M. H., Chemoprevention of colonic tumorigenesis by dietary hydroxylated polymethoxyflavones in azoxymethane-treated mice. Mo/. Nutr. Food Res. 2011, 55, (2), 278-90.
  • Hu, M.; Li, Y.; Decker, E. A.; Xiao, H.; McClements, D. J., Impact of Layer Structure on Physical Stability and Lipase Digestibility of Lipid Droplets Coated by Biopolymer Nanolaminated Coatings. Food Biophys. 2011, 6, (1 ), 37-48.
  • Choi, S. J.; Decker, E. A.; Henson, L.; Popplewell, L. M.; Xiao, H.; McClements, D. J., Formulation and properties of model beverage emulsions stabilized by sucrose monopalmitate: Influence of pH and lyso-lecithin addition. Food Res. Int. 2011, 44, (9), 3006-3012.

2010

  • Yang, Z.; Xiao, H.; Jin, H.; Koo, P. T.; Tsang, D. J.; Yang, C. S., Synergistic actions of atorvastatin with y-tocotrienol and celecoxib against human colon cancer HT29 and HCT116 cells. Int. J. Cancer 2010, 126, (4), 852-863.
  • Qiu, P.; Dong, P.; Guan, H.; Li, S.; Ho, C. T.; Pan, M. H.; McClements, D. J.; Xiao, H.*, Inhibitory effects of 5-hydroxy polymethoxyflavones on colon cancer cells. Mo/. Nutr. Food Res. 2010, 54 Suppl 2, S244-52.
  • Lu, G.; Xiao, H.; Li, G. X.; Picinich, S. C.; Chen, Y. K.; Liu, A.; Lee, M. J.; Loy, S.; Yang, C. S., A gamma-tocopherol-rich mixture of tocopherols inhibits chemically induced lung tumorigenesis in A/J mice and xenograft tumor growth. Carcinogenesis 2010, 31, (4), 687-94.
  • Li, Y.; Hu, M.; Xiao, H.; Du, Y.; Decker, E. A.; McClements, D. J., Controlling the functional performance of emulsion-based delivery systems using multi- component biopolymer coatings. Eur. J. Pharm. Biopharm. 2010, 76, (1 ), 38- 47.
  • Li, S.; Wang, Y.; Wang, Z.; Xiao, H.; Lo, C. Y.; Rawson, N.; Ho, C. T., Quantitative analysis of hydroxylated polymethoxyflavones by high-performanceliquid chromatography. Biomed. Chromatogr. 2010, 24, (8), 838-45.
  • Li, G.-X.; Chen, Y.-K.; Hou, Z.; Xiao, H.; Jin, H.; Lu, G.; Lee, M.-J.; Liu, B.; Guan, F.; Yang, Z.; Yu, A.; Yang, C. S., Pro-oxidative activities and dose-response relationship of(-)­epigallocatechin-3-gallate in the inhibition of lung cancer cell growth: a comparative study in vivo and in vitro. Carcinogenesis 2010, 31, (5), 902-10.
  • Hu, M.; Li, Y.; Decker, E. A.; Xiao, H.; McClements, D. J., Influence of tripolyphosphate cross­linking on the physical stability and lipase digestibility of chitosan-coated lipid droplets. J. Agric. Food Chem. 2010, 58, (2), 1283-9.
  • Dong, P.; Qiu, P.; Zhu, Y.; Li, S.; Ho, C. T.; McClements, D. J.; Xiao, H.*, Simultaneous determination of four 5-hydroxy polymethoxyflavones by reversed-phase high performance liquid chromatography with electrochemical detection. J. Chromatogr. A 2010, 1217, (5), 642-7.

2009

  •  
  • Xiao, H.*; Yang, C. S.; Li, S.; Jin, H.; Ho, C. T.; Patel, T., Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis. Mo/. Nutr. Food Res. 2009, 53, (3), 398-406.
  • Xiao, H.*, Potential enhancement of cancer inhibition by using statins in combination with pharmacological and dietary agents. Cancer & Chemotherapy Reviews 2009, 4, (4), 183-192.
  • Li, Y.; Le Maux, S.; Xiao, H.; McClements, D. J., Emulsion-based delivery systems for tributyrin, a potential colon cancer preventative agent. J. Agric. Food Chem. 2009, 57, (19), 9243-9.
  • Ju, J.; Hao, X.; Lee, M.-J.; Lambert, J. D.; Lu, G.; Xiao, H.; Newmark, H. L.; Yang, C. S., A y­tocopherol-rich mixture of tocopherols inhibits colon inflammation and carcinogenesis in azoxymethane and dextran sulfate sodium-treated mice. Cancer Prev. Res. 2009, 2, (2), 143-152.

2008

  • Yang, C. S.; Ju, J.; Lu, G.; Xiao, H.; Hao, X.; Sang, S.; Lambert, J. D., Cancer prevention by tea and tea polyphenols. Asia Pac. J. Clin Nutr. 2008, 17 Suppl 1, 245-8.
  • Xiao, H.*; Zhang, Q.; Lin, Y.; Reddy, B. S.; Yang, C. S., Combination of atorvastatin and celecoxib synergistically induces cell cycle arrest and apoptosis in colon cancer cells. Int. J. Cancer 2008, 122, (9), 2115-24.
  • Xiao, H. *; Yang, C. S., Combination regimen with statins and NSA/Ds: a promising strategy for cancer chemoprevention. Int. J. Cancer 2008, 123, (5), 983-90.
  • Xiao, H.*; Hao, X.; Simi, B.; Ju, J.; Jiang, H.; Reddy, B. S.; Yang, C. S., Green tea polyphenols inhibit colorectal aberrant crypt foci (ACF) formation and prevent oncogenic changes in dysplastic ACF in azoxymethane-treated F344 rats. Carcinogenesis 2008, 29, (1 ), 113-9.
  • Lu, G.; Xiao, H.*; You, H.; Lin, Y.; Jin, H.; Snagaski, B.; Yang, C. S., Synergistic Inhibition of Lung Tumorigenesis by a Combination of Green Tea Polyphenols and Atorvastatin. Clin. Cancer Res. 2008, 14, (15), 4981-4988.
  • Liu, Y.; Xiao, H.; Tian, Y.; Nekrasova, T.; Hao, X.; Lee, H.J.; Suh, N.; Yang, C. S.; Minden, A., The Pak4 Protein Kinase Plays a Key Role in Cell Survival and Tumorigenesis in Athymic Mice. Mo/. Cancer Res. 2008, 6, (7), 1215-24.
  • Liu, Y.; Ju, J.; Xiao, H.; Simi, B.; Hao, X.; Reddy, B. S.; Huang, M. T.; Newmark, H.; Yang, C. S., Effects of combination of calcium and aspirin on azoxymethane-induced aberrant crypt foci formation in the colons of mice and rats. Nutr. Cancer 2008, 60, (5), 660-5.

2007 and before

  • Xiao, H.*; Parkin, K. L., Isolation and identification of potential cancer chemopreventive agents from methanolic extracts of green onion (Allium cepa). Phytochemistry 2007, 68, (7), 1059-1067.
  • Suh, N.; Paul, S.; Hao, X.; Simi, B.; Xiao, H.; Rimando, A. M.; Reddy, B. S., Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats. Clin. Cancer Res. 2007, 13, (1 ), 350- 5.
  • Xiao, H.*; Parkin, K. L., Induction of Phase II Enzyme Activity by Various Selenium Compounds. Nutr. Cancer 2006, 55, (2), 210-223.
  • Xiao, H.*; Parkin, K., Isolation and identification of phase II enzyme-inducing agents from Non polar Extracts of Green Onion (Alli um spp. ). J. Agric. Food Chem. 2006, 54, (22), 8417-8424.
  • Xiao, H.*; Parkin, K. L., Antioxidant functions of selected allium thiosulfinates and S-alk(en)yl­L-cysteine sulfoxides. J. Agric. Food Chem. 2002, 50, (9), 2488-93.
  • Wettasinghe, M.; Bolling, B.; Plhak, L.; Xiao, H.; Parkin, K., Phase II enzyme- inducing and antioxidant activities of beetroot (Beta vulgaris L.) extracts from phenotypes of different pigmentation. J. Agric. Food Chem. 2002, 50, (23), 6704-9.
  • Shen, C.; Xiao, H.; Parkin, K. L., In vitro stability and chemical reactivity of thiosulfinates. J. Agric. Food. Chem. 2002, 50, (9), 2644-51.
  • Briggs, W. H.; Xiao, H.; Parkin, K. L.; Shen, C.; Goldman, I. L., Differential inhibition of human platelet aggregation by selected Allium thiosulfinates. J. Agric. Food Chem. 2000, 48,(11), 5731-5.
  • Briggs, W. H.; Folts, J.D.; Osman, H.E.; Xiao, H.; Parkin, K.L.; Goldman, I.L., Administration of Onion (Alli um cepa) Abolishes In vivo Platelet-Mediated Thrombosis. Proceeding of the Third International Symposium on Edible Alliaceae 2000, 122-126.
  • Gu, Q.-q.; Fang, Y.-c.; Wang , C.-y.; Xiao, H.; Qin, Y.-q., Studies on the antitumor activity and isolation of the glycoprotein from the gonad of Chlamys (Azumapecten) farreri. Chinese Journal of Oceanology and Limnology1998, 16, (4 ), 359-363.
  • Chu, C. L.; Gu, Q.Q.; Fang, Y.C.; Xiao, H.; Zheng, Y. Z., Bioactive components from Ascidian. Chinese Journal of Marine Drugs 1998, (67), 35-46

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