School or College:
Research Proposal Title:
Menopause is accompanied by a rapid slowdown of metabolism, resulting in an increased risk of obesity and its associated metabolic diseases such as type 2 diabetes. Hyperthermia therapy, like saunas or hot baths, has long been used to relieve pain and attenuate the risk of metabolic diseases in older adults. However, the scientific evidence on the benefits of hyperthermia therapy has yet to be clearly elucidated. Our preliminary work revealed that hyperthermia treatment significantly reduced diet-induced obesity by increasing energy expenditure in ‘old’-female mice. This proposal aims to investigate the underlying mechanism of hyperthermia and the extent to which it mitigates metabolic slowdown using a rodent model of menopause, which can ultimately be applied to menopausal women.