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Exposures to environmental pollutants have now been identified as playing a role in the way that metabolically important organs like the liver and the pancreas develop and function. Little research has been conducted in vivoto characterize PCB-11’s potential effects on human health. The work conducted for this dissertation uses the zebrafish model to assess whether early developmental exposures to PCB-11 result in toxicity in ways that might predispose the individual to metabolic disease later in life. A big portion of the experiments investigate how PCB-11 affects an important liver enzyme that helps metabolize environmental pollutants, Cyp1a, in both single and co-exposures with other environmental pollutants. Another portion of the experiments model human-relevant chronic exposures to PCB-11 in the first 15 days of life for zebrafish, which in humans translates to a juvenile stage. The 15-day studies in zebrafish investigate growth, primary pancreatic islet development, hepatic lipid accumulation, fatty acid profiling, the role of oxidative stress, and global gene expression to see what kinds of biological pathways are affected under this exposure setting. These research results matter in the context of potential importance for environmental regulation updates, as well as to the public in terms of awareness of consumer products that might contain PCB-11.