Due to the increase in anti-immigration policies that have promoted a sharp rise in xenophobia in recent years, experiences of discrimination have become a pervasive and salient stressor for Latinx youth, which puts them at greater risk for the development of psychopathology. In particular, interpersonal discriminatory experiences have been found to negatively impact youth of colors’ biological functioning and their mental health. Yet research to date has examined how different experiences of discrimination (i.e., personal vs. vicarious) impact Latinx youths’ mental health, specifically through biological dysregulation. Furthermore, past and present literature tend to treat Latinx identities as homogenous and fails to consider the complex phenotypic variations across Latinx subgroups resulting from a long history of admixture between Africans, Indigenous and Europeans. Ultimately, this research has the potential to further our understanding of factors that contribute to the rates of discrimination that Latinx youths experience in their day-to-day lives, and the negative impact it has on their biological functioning and psychological wellbeing.