Dr. Lee's research is centered on developing bioengineered bone marrow where bone and blood biology are functionally integrated, for basic and translational research purposes. These models strive to facilitate a comprehensive understanding of bone marrow development, aging, and metastasis, ultimately leading to targeted anti-aging and anti-metastasis pharmacological strategies. The successful creation of humanized bone and marrow models holds significant potential for impacting bone marrow transplantation and living bone grafts. To reproduce the unique complexity of bone marrow, which consists of the hardest (bone) and softest (marrow) tissues, Dr. Lee employs advanced biomaterials, stem cell biology, and various mechanoculture techniques. This approach enables him to replicate the biophysical and biochemical intricacies of the human body in microphysiological bone marrow tissue models. Dr. Lee aims to establish, validate, and apply human bone marrow models in the realms of aging and cancer research.