My primary interest is in the area of human skeletal muscle function and fatigue. In particular, our work examines the mechanisms of fatigue, and how these vary depending upon age, gender, chronic health status and habitual physical activity level. A related interest is an examination of the influence that fatigue has on functional capacity. We take a state-of-the-art, integrated approach to understanding human muscle function from the cell to the organism. The main problem we are working on now is how to minimize the loss of mobility and health that occur in old age.