Brian Whitcomb's research focues on epidemiologic evaluation of the immune system and inflammatory factors in adverse pregnancy outcomes and menstrual cycle function and dysfunction. Using serum samples collected early in gestation from participants in a large study of pregnancy, we have considered levels of a panel of cytokines, including Th1, Th2 and growth factors, comparing cases of miscarriage and matched controls.

We have also considered serum levels of granulocyte-colony stimulating factor in preterm birth, an outcome suspected to be affected by infection. Additionally, we have evaluated cytokine levels in urine specimens in a longitudinal study of menstrual cycle function among healthy normally menstruating women to assess relations with hormones and other factors.