Orchestrating Immunological Symphony in Type 2 Diabetes
Jason K. Kim, Ph.D.
Obesity is a leading cause of type 2 diabetes, and inflammation plays a critical role as a molecular link. This lecture presents how inflammation causes insulin resistance, an early characteristic of type 2 diabetes, as cytokines regulate glucose metabolism in skeletal muscle and liver. Pro-inflammatory macrophages are involved in this obesity-mediated event, including liver disease. In all, obesity and aging are physiological states of low-grade, systemic...