In 1971, Seymour joined the University of Massachusetts Amherst’s Department of Communication Disorders first as an assistant professor. She served as the director of the Communication Disorders Clinic at the UMass in 1974 and was appointed chair of the department and dean of the Graduate School. In 2001, Seymour assumed the position of interim provost and senior vice chancellor for Academic Affairs. In 2004, she was appointed provost. Seymour later retired from UMass to serve as provost of Simmons College in Boston in 2009.