UMass Amherst’s Reika Katsumata, assistant professor of polymer science and engineering, is one of 58 researchers to receive grants from the Air Force Office of Scientific Research (AFOSR).

Katsumata has received a three-year, $450,000 YIP Award from AFOSR to support her project, “Confinement Effects on Polymer Degradation in Nanocomposites.”

Nanocomposite materials are commonly used in microelectronics and aerospace engineering. Thermal stability of these materials is crucial for reliability at high temperatures and in harsh conditions. 

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In a discovery with wide-ranging implications, researchers at the University of Massachusetts Amherst recently announced in the Proceedings of the National Academy of Sciences that uniformly charged macromolecules—or molecules, such as proteins or DNA, that contain a large number of atoms all with the same electrical charge—can self-assemble into very large structures. This finding upends our understanding of how some of life’s basic structures are built.

Traditionally, scientists have understood charged polymer chains as being composed of smaller, uniformly charged units. Such chains, called polyelectrolytes, display predictable behaviors of self-organization in water: they will repel each other because similarly charged objects don’t like to be close to each other. If you add salt to water containing polyelectrolytes, then molecules coil up, because the chains’ electrical repulsion is screened by the salt.

However, “the game is very different when you have dipoles,” says Murugappan Muthukumar, the Wilmer D. Barrett Professor in Polymer Science and Engineering at UMass Amherst the study’s senior author.

While many molecules have either a positive or negative charge, dipoles have both. This means that polymers composed of dipoles behave very differently from the more familiar polyelectrolytes, which have either a positive or negative electrical charge: they expand in a salty solution and can form cross-links with other dipole polymer chains, which then leads to the formation of complex polymer structures.

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Researchers at the University of Massachusetts Amherst recently announced that they have engineered a new class of material, called a “polyzwitterionic complex,” or “pZC,” which is able to both withstand the harsh acidic conditions of the stomach and then dissolve predictably in the comparatively gentle environment of the small intestine. This property means that pZCs could help revolutionize the delivery of medicines of all sorts, from familiar oral antibiotics to new classes of delicate protein therapeutics.

“Despite the common experience of swallowing medications orally, there is a huge number of therapies that are not available orally,” says Khatcher Margossian, the lead author of the study and a candidate for a dual M.D./Ph.D. from Rush Medical College and the UMass Amherst Department of Polymer Science and Engineering, respectively. This is because there are many drugs that can’t withstand the stomach’s harshly acidic environment. Two ways around this problem are to either inject or implant medications; but in both cases, the pain, fear and potential side effects can limit a patient’s willingness to undergo treatment or to stick with the treatment plan through its full course. And even those drugs that are strong enough to withstand the stomach’s acid and make it through to the small intestine, where they can be absorbed into the bloodstream, often do not make it through entirely intact. “The doses of oral medications are usually larger than what our body really needs,” explains Murugappan Muthukumar, the Wilmer D. Barrett Professor in Polymer Science and Engineering at UMass Amherst and the study’s senior author. “This is because some of the medication decomposes in the stomach.”

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