Yu Chen
Associate Professor
Research Interests
My research interests include development of novel quantitative optical sensing and imaging devices for clinical translation, and preclinical and clinical applications of optical technologies in imaging brain function, renal physiology, cancer therapy, and tissue engineering. Specific imaging modalities include: optical coherence tomography (OCT), laminar optical tomography (LOT), and multiphoton microscopy (MPM).
Current Research
1. Evaluation of transplant kidney viability using non-destructive OCT imaging and automatic image analysis;
2. Depth-resolved imaging of drug distribution in murine tumor models;
3. Development of standardized testing methods for evaluation of optical imaging / sensing systems.
Academic Background
- BS in Physics, Peking University 1997
- PhD in Bioengineering, University of Pennsylvania 2003
- Postdoc, MIT 2003-2007
B. Konkel, et al., “Fully automated analysis of OCT imaging of human kidneys for prediction of post-transplant function.” Biomedical Optics Express, 10, 1794-1821 (2019).
Q. Tang, et. al, “3D Mesoscopic Fluorescence Tomography for Imaging Micro-distribution of Antibody-photon Absorber Conjugates during Photoimmunotherapy in vivo.” Journal of Controlled Release, 279, 171-180 (2018).
Q. Tang, et. al, “Imaging stem cell distribution, growth, migration, and differentiation in 3-D scaffolds for bone tissue engineering using mesoscopic fluorescence tomography.” Biotechnology and Bioengineering, 115, 257–265 (2018).
Q. Tang, et. al, “Real-time monitoring of microdistribution of antibody-photon-absorber conjugates during photoimmunotherapy in vivo.” Journal of Controlled Release, 260, 154-163 (2017).
Q. Tang, et. al, “Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography.” Biomedical Optics Express, 7, 5218-5232 (2016).
