The University of Massachusetts Amherst

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Yahya Modarres-Sadeghi

Associate Professor

At the FSI Lab, we use experimental, theoretical and numerical tools to understand different Fluid-Structure Interaction phenomena both from a fundamental point of view and with applications in several fields including biomedical science. An example is the problem of cerebral aneurysms. Cerebral aneurysms are the dilation of part of the wall of an artery in the brain. They can occur at any age, their formation is multifactorial and results from the interplay between a biological process in the arterial wall and hemodynamic forces and stimuli which act on the wall. Repetitive forces on an existing aneurysm can lead either to its gradual expansion or to a sudden rupture, the latter causing a severely disabling and sometimes devastating or fatal intracranial hemorrhage. The artery, the aneurysm attached to it and the pulsatile blood flow inside the artery constitute an FSI problem with flexible structures – arteries and the aneurysm – in contact with pulsatile blood flow. We use advanced FSI modeling tools to derive reduced order models, which can be used to predict the rate of growth and the risk of rupture of cerebral aneurysms.

Current Research
Simulating physiological flows using computational fluid dynamics (CFD) remains to be computationally expensive and difficult for clinical usage. We use reduced order models (ROM) of such systems with high nonlinearity and geometrical non-uniformity to replace the full, nonlinear system with a low degree of freedom ROM model. We construct ROM models by proper orthogonal decomposition (POD) method to estimate the flow-induced wall shear stress (WSS) and pressure loading of abdominal aortic aneurysms and bifurcation cerebral aneurysms. This method allows us to investigate a wide domain of different physiological flow parameters without conducting the computationally expensive CFD simulations repetitively, thus it is promising for clinical usage.

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Academic Background

  • Ph.D. of Mechanical Engineering, McGill University, Montreal, Canada, 2006
  • M.Sc. of Mechanical Engineering, University of Tehran, Tehran, Iran, 2001
  • B.Sc. of Mechanical Engineering, Sharif University of Technology, Tehran, Iran, 1998
B. Liu, S. Han, B. Hedrick, Y. Modarres-Sadeghi, M.E. Lynch (2018). Perfusion applied to a 3D model of bone metastasis results in evenly dispersed mechanical stimuli. Biotechnology and Bioengineering. 115, 1076-1085.
G.H. Chang, Y. Modarres-Sadeghi (2017). Flow-Induced Buckling of Flexible Shells with Non-zero Gaussian Curvatures and Thin Spots. Soft Matter.13, 2465-2474.
G.H. Chang, C.M. Schirmer, Y. Modarres-Sadeghi (2017). A Reduced Order Model for Wall Shear Stress in Abdominal Aortic Aneurysms by Proper Orthogonal Decomposition. Journal of Biomechanics. 54, 33-43.
G.H. Chang, Y. Modarres-Sadeghi (2016). Flow-Induced Instabilities of Shells of Revolution with Non-zero Gaussian Curvatures Conveying Fluid. Journal of Sound and Vibration, 363, 600-612.
G.H. Chang, Y. Modarres-Sadeghi (2016). A Model for Wall Shear Stress Estimation in Abdominal Aortic Aneurysms using Proper Orthogonal Decomposition XXIV ICTAM, 21-26 August 2016, Montreal, Canada.
Contact Info

Department of Mechanical and Industrial Engineering
Gunness 10B
160 Governors Drive
Amherst, MA 01003-9292

(413) 545-2468