Vincent Rotello

Goessmann Professor of Chemistry, University Distinguished Professor

Our research encompasses multiple applications of nanomaterials in point-of care diagnostics and high-throughput high-content screening tools.

Current Research
We are currently developing a range of platforms for next-generation diagnostics. We have created array-based sensing strategies for detection of liver disease, and are extending this work to cardiac incident diagnosis. Simultaneously, we are developing tools for high-throughput high-content screens for determination of chemotherapeutic mechanisms and infection diagnostics. We are also applying these hypothesis-free sensors to cancer stem cell differentiation, identifying agents that effect novel de-stemming processes.

Learn more at elements.chem.umass.edu/rotellogroup/

Academic Background

BSc (Honors) Illinois Institute of Technology, 1985
MPhil Yale University, 1987
PhD Yale University, 1990
Postdoctoral Training: NSF Postdoctoral Fellowship MIT, 1990

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Ngernpimai, S.; Geng, Y. Y.; Makabenta, J. M.; Landis, R. F.; Keshri, P.; Gupta, A.; Li, C. H.; Chompoosor, A.; Rotello, V. M. "Rapid Identification of Biofilms Using a Robust Multichannel Polymer Sensor Array" ACS Appl. Mater. Interfaces 2019, 11, 11202-11208.

Geng, Y. Y.; Goel, H. L.; Le, N. B.; Yoshii, T.; Mout, R.; Tonga, G. Y.; Amante, J. J.; Mercurio, A. M.; Rotello, V. M. "Rapid phenotyping of cancer stem cells using multichannel nanosensor arrays" Nanomed.-Nanotechnol. Biol. Med. 2018, 14, 1931-1939.

Le, N. D. B.; Wang, X.; Geng, Y. Y.; Tang, R.; Tonga, G. Y.; Jiang, Z. W.; Rotello, V. M. "Rapid and ultrasensitive detection of endocrine disrupting chemicals using a nanosensor-enabled cell-based platform" Chem. Commun. 2017, 53, 8794-8797.

Duncan, B.; Le, N. D. B.; Alexander, C.; Gupta, A.; Tonga, G. Y.; Yazdani, M.; Landis, R. F.; Wang, L. S.; Yan, B.; Burmaoglu, S.; Li, X. N.; Rotello, V. M. "Sensing by Smell: Nanoparticle-Enzyme Sensors for Rapid and Sensitive Detection of Bacteria with Olfactory Output" ACS Nano 2017, 11, 5339-5343.

Rana, S.; Le, N. D. B.; Mout, R.; Saha, K.; Tonga, G. Y.; Bain, R. E. S.; Miranda, O. R.; Rotello, C. M.; Rotello, V. M. "A multichannel nanosensor for instantaneous readout of cancer drug mechanisms" Nature Nanotechnol. 2015, 10, 65-69.

Our research encompasses multiple applications of nanomaterials in therapeutics and diagnostics, including both nanoparticles and nano/micropatterned surfaces.

Vincent Rotello

Institute for Applied Life Sciences