The University of Massachusetts Amherst
( A B C D F G H J K L M N P R S T V W X Y Z

Please select the first letter of the last name you are looking for.

Lili He

Associate Professor

Dr. He's major research focus is to develop and apply the most advanced and innovative analytical techniques to help solve critical and emerging issues in food science. The central tool of Lili’s research is surface enhanced Raman spectroscopy (SERS), which is a combination of Raman spectroscopy and nano-techniques. The use of metallic nanostructure enhances the Raman signals more than a million times. Her group has developed various SERS based techniques for food safety and food chemistry applications.

Current Research
Dr. He's current research involves the use of SERS for the study of chemical, biological, and engineered nanoparticles contaminants in complex food matrices. For chemical detection, we have developed several innovative SERS methods for rapid detection of pesticides on and in different food matrices. Recently, we also developed an in situ method to analyze pesticide penetration in plant tissues using gold nanoparticles as probes. For bacterial detection, we have developed a mapping method to detect, identify and quantify multi-bacterial cells on a SERS substrate. Nanoparticle contaminants are a recent focus in my lab, we have successfully developed several SERS methods to detect silver nanoparticles and titanium dioxide nanoparticles in complex matrices.

Learn more at

Academic Background

  • 2004 BS Plant Protection, Zhejiang University, China
  • 2006 MS Plant Pathology, Zhejiang University, China
  • 2009 PhD Food Science, University of Missouri-Columbia
  • 2009-2012 Postdoc Food Science, University of Minnesota
Tu, Qin, Tianxi Yang, Yanqi Qu, Siyue Gao, Zhiyun Zhang, Yilei Wang, Jinyi Wang, and Lili He*. "In situ colorimetric detection of glyphosate on plant tissues using cysteamine-modified gold nanoparticles." Analyst (2019). 144, 2017-2025.
Yang, Tianxi, Jeffery J. Doherty, Huiyuan Guo, Bin Zhao, John M. Clark, Baoshan Xing, Ruyan Hou, and Lili He*. "Real-time monitoring of pesticide translocation in tomato plants by surface-enhanced Raman spectroscopy." Analytical chemistry (2019). 91, 3, 2093-2099
Tu, Qin, Michael E. Hickey, Tianxi Yang, Siyue Gao, Qingmiao Zhang, Yanqi Qu, Xinyi Du, Jinyi Wang, and Lili He*. "A simple and rapid method for detecting the pesticide fipronil on egg shells and in liquid eggs by Raman microscopy." Food Control (2019). 96. 16-21.
Zhang, Zhiyun, Huiyuan Guo, Chuanxin Ma, Ming Xia, Jason C. White, Baoshan Xing, and Lili He*. "Rapid and efficient removal of silver nanoparticles from plant surfaces using sodium hypochlorite and ammonium hydroxide solution." Food Control 98 (2019): 68-73.
Guo, Huiyuan, Leigh C. Hamlet, Lili He*, and Baoshan Xing*. "A field-deployable surface-enhanced Raman scattering (SERS) method for sensitive analysis of silver nanoparticles in environmental waters." Science of The Total Environment 653 (2019): 1034-1041.
Gao, Siyue, Brooke Pearson, and Lili He*. Mapping bacteria on filter membranes, an innovative SERS approach. Journal of microbiological methods 147 (2018): 69-75.
Guo, Huiyuan, Lili He*, and Baoshan Xing*. "Applications of surface-enhanced Raman spectroscopy in the analysis of nanoparticles in the environment." Environmental Science: Nano 4.11 (2017): 2093-2107.
Zhang, Ye, Shaojie Zhao, Jinkai Zheng*, and Lili He*. 2017. "Surface-enhanced Raman spectroscopy (SERS) combined techniques for high-performance detection and characterization." TrAC Trends in Analytical Chemistry.
Yang, T., Wang, P., Guo, H., He, L.*, 2016. Surface-Enhanced Raman Spectroscopy: A Tool for All Classes of Food Contaminants. Reference Module in Food Sciences. Elsevier, pp. 1–8.
Pang, Shintaro, Tianxi Yang, and Lili He*. 2016. "Review of surface enhanced Raman spectroscopic (SERS) detection of synthetic chemical pesticides."TrAC Trends in Analytical Chemistry.
Jinkai Zheng and Lili He*. 2014. Surface-Enhanced Raman Spectroscopy for the Chemical Analysis of Food. Comprehensive Reviews in Food Science and Food Safety. 13 (3), 317-328.
Contact Info

Department of Food Science
Chenoweth 344
102 Holdsworth Way
Amherst, MA 01003

(413) 545-5847