The University of Massachusetts Amherst

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Lili He

Assistant Professor

Dr. He's major research focus is to develop and apply the most advanced and innovative analytical techniques to help solve critical and emerging issues in food science. The central tool of Lili’s research is surface enhanced Raman spectroscopy (SERS), which is a combination of Raman spectroscopy and nano-techniques. The use of metallic nanostructure enhances the Raman signals more than a million times. Her group has developed various SERS based techniques for food safety and food chemistry applications.

Current Research
Dr. He's current research involves the use of SERS for the study of chemical, biological, and engineered nanoparticles contaminants in complex food matrices. For chemical detection, we have developed several innovative SERS methods for rapid detection of pesticides on and in different food matrices. Recently, we also developed an in situ method to analyze pesticide penetration in plant tissues using gold nanoparticles as probes. For bacterial detection, we have developed a mapping method to detect, identify and quantify multi-bacterial cells on a SERS substrate. Nanoparticle contaminants are a recent focus in my lab, we have successfully developed several SERS methods to detect silver nanoparticles and titanium dioxide nanoparticles in complex matrices.

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Academic Background

  • 2004 BS Plant Protection, Zhejiang University, China
  • 2006 MS Plant Pathology, Zhejiang University, China
  • 2009 PhD Food Science, University of Missouri-Columbia
  • 2009-2012 Postdoc Food Science, University of Minnesota
Shintaro Pang and Lili He*. 2016. Understanding the Competitive Interactions in the Aptamer-Gold Nanoparticle Based Colorimetric Assays using Surface Enhanced Raman Spectroscopy (SERS) . Analytical Method. DOI: 10.1039/C5AY03158C
Huiyuan Guo, Baoshan Xing* and Lili He*. 2016. Development of a filter-based method for detecting silver nanoparticles and their heteroaggregation in aqueous environments by surface-enhanced Raman spectroscopy. Environmental Pollution. 10.1016/j.envpol.2015.12.049.
Panxue Wang, Shintaro Pang, Juhong Chen, Lynne McLandsborough, Sam R. Nugen, Mingtao Fan and Lili He*. 2016. Label-free mapping of single bacterial cells using surface-enhanced Raman spectroscopy. Analyst. DOI: 10.1039/C5AN02175H.
Panxue Wang, Shintaro Pang, Hua Zhang, Mingtao Fan, Lili He*. 2015. Surface enhanced Raman scattering characterization of Lactococcus lactis responding to ampicillin and ciprofloxacin. Analytical and Bioanalytical Chemistry. doi:10.1007/s00216-015-9184-2
Siyue Gao, Jessica Glasser, Lili He*. 2015. A filter-based surface enhanced Raman spectroscopic assay for rapid detection of chemical contaminants. JoVE. In press.
Ruyan Hou, Shintaro Pang, Lili He*. 2015. In situ SERS detection of multi-class insecticides on plant surfaces. Analytical Methods. DOI: 10.1039/C5AY01058F.
Tingting Lang, Shintaro Pang, Lili He*. 2015 Integration of colorimetric and SERS detection for rapid screening and validation of melamine in milk. DOI: 10.1039/C5AY00955C.
Guo, Huiyuan; Zhang, Zhiyun; Xing, Baoshan*; Mukherjee, Arnab; Musante, Craig; White, Jason; He, Lili*. 2015. Analysis of Silver Nanoparticles in Antimicrobial Products Using Surface-Enhanced Raman Spectroscopy (SERS). Environmental Science & Technology. 49 (7), pp 4317–4324
Jinkai Zheng, Shintaro Pang, TP Labuza and Lili He*. 2014. Evaluation of surface-enhanced Raman scattering detection using a handheld and a bench-top Raman spectrometer: a comparative study. Talanta. 129, 1, 79-85.
Jinkai Zheng, Lili He*. 2014. Surface-Enhanced Raman Spectroscopy for the Chemical Analysis of Food. Comprehensive Reviews in Food Science and Food Safety. 13 (3), 317-328.
Wijaya, Wisiani, Shintaro Pang, Theodore P Labuza and Lili He*. 2014. “Rapid Detection of Acetamiprid in Foods Using Surface-Enhanced Raman Spectroscopy (SERS).” Journal of Food Science. 79 (4), T743-T747
Pang, Shintaro, Theodore P Labuza and Lili He*. 2014. “Development of a Single Aptamer-based Surface Enhanced Raman Scattering Method for Rapid Detection of Multiple Pesticides.” The Analyst. 139 (8), 1895-1901. DOI:10.1039/C3AN02263C.
Jinkai Zheng, Shintaro Pang, TP Labuza and Lili He*. 2013. Semi-quantification of Surface-enhanced Raman Scattering using a Handheld Raman Spectrometer: A Feasibility Study. Analyst. 138, 7075-7078.
Contact Info

Department of Food Science
Chenoweth 344
102 Holdsworth Way
Amherst, MA 01003

(413) 545-5847