Jae-Hwang Lee

Associate Professor

Mechanical properties of individual cells are determined by a specific composition and an arrangement of sub-cellular organelles. Since cells can be viewed as heterogeneous polymeric materials exhibiting strain-rate dependent mechanical properties, we are interested in cells’ nonlinear mechanical responses in high-strain-rate regimes and the development of high-strain-rate biomechanical characterization methods.

Current Research
In order to apply HSR mechanical stimuli to a single cell, we are trying to employ a recently developed micro-ballistics technique that can produce a high-speed collision of a single micro-particle to a target specimen. Utilizing extreme mechanical stimuli from the microscopic collision, we are trying to differentiate any subtle difference in the intrinsic mechanical properties of individual cancer cells.

Learn more at blogs.umass.edu/leejh/

Academic Background

BS Physics, Dankook University, South Korea, 1994
MS Physics, Dankook University, South Korea, 1996
PhD Condensed Matter Physics, Iowa State University, 2006
Postdoctoral Associate, Ames Laboratory-USDOE, 2006-207
Postdoctoral Associate, Materials Science & Engineering, MIT 2007-2011
Research Scientist, Rice University, 2011-2014

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Publications

W. Xie, J.-H. Lee, “Intrinsic Dynamics and Toughening Mechanism of Multilayer Graphene upon Microbullet Impact” ACS Applied Nanomaterials 3, 9185-9191 (2020). https://doi.org/10.1021/acsanm.0c01267

C.W. Barney, C.E. Dougan, K.R. McLeod, A. Kazemi-Moridani, Y. Zheng, Z. Ye, S. Tiwari, I. Sacligil, R.A. Riggleman, S. Cai, J.-H. Lee, S.R. Peyton, G.N. Tew, A.J. Crosby, “Cavitation in Soft Matter“, PNAS 117, 9157-9165 (2020). https://doi.org/10.1073/pnas.1920168117

W. Xie, J.-H. Lee, “Dynamics of Entangled Networks in Ultrafast Perforation of Polystyrene Nanomembranes“, Macromolecules, 53, 1701-1705 (2020). https://doi.org/10.1021/acs.macromol.9b0226553

W. Xie, R. Zhang, R.J. Headrick, L. Taylor, S.E. Kooi, M. Pasquali, S. Muftu, J.-H. Lee, “Dynamic strengthening of carbon nanotube fibers under extreme mechanical impulse”, Nano Letters 19, 3519 (2019).

https://doi.org/10.1021/acs.nanolett.9b00350

E.P. Chan, W. Xie, S.V. Orski, J.-H. Lee, C.L. Soles, “Entanglement density-dependent energy absorption of polycarbonate films via supersonic fracture” ACS Macro Letters 8, 806 (2019).

https://doi.org/10.1021/acsmacrolett.9b00264

W. Xie, S. Tadepalli, S.H. Park, A. Kazemi-Moridani, Q. Jiang, S. Singamaneni, J.-H. Lee, “Extreme mechanical behavior of nacre-mimetic graphene-oxide and silk nanocomposites” Nano Letters 18, 987 (2018).

https://doi.org/10.1021/acs.nanolett.7b04421

W. Xie, A. Alizadeh-Dehkharghani, Q. Chen, V.K. Champagne, X. Wang, A.T. Nardi, S. Kooi, S. Müftü, J.-H. Lee, “Dynamics and extreme plasticity of metallic microparticles in supersonic collisions” Scientific Reports 7, 5073 (2017).

https://doi.org/10.1038/s41598-017-05104-7

D.-P. Song, C. Li, N.S. Colella, W. Xie, S. Li, X. Lu, S. Gido, J.-H. Lee, J.J. Watkins, “Large-volume self-organization of polymer/nanoparticle hybrids with millimeter-scale grain sizes using brush block copolymers” Journal of the American Chemical Society 137, 12510 (2015).

https://doi.org/10.1021/jacs.5b08632

J.-H. Lee, P.E. Loya, J. Lou, E.L. Thomas, “Dynamic mechanical behavior of multilayer graphene via supersonic projectile penetration” Science 346, 1092 (2014).

http://dx.doi.org/10.1126/science.1258544

Jae-Hwang Lee

Institute for Applied Life Sciences