After finishing her doctorate, Rema worked with a variety of United Nations agencies including UNDP, UNIFEM, and UNICEF. Her principal activities included Multi-Country Programming and Grants Management; Metrics and Evaluation; Public Relations; High level advocacy with UN Missions and Embassies; and Representation at conferences and meetings.
In 2003 she became the Director for Public Health with the American India Foundation which is committed to improving the lives of India’s underprivileged, with a special focus on women, children, and youth.