In the News

‘Phyjama’ to be introduced at Ubicomp

Graduate students Ali Kiaghadi and S. Zohreh Homayounfar, with their professors Trisha L. Andrew, a materials chemist, and computer scientist Deepak Ganesan, will introduce their health-monitoring sleepwear “phyjamas” at the Ubicomp 2019 conference this week in London, U.K.

As Andrew explains, “The challenge we faced was how to obtain useful signals without changing the aesthetics or feel of the textile. Generally, people assume that smart textiles refer to tightly worn clothing that has various sensors embedded in it for measuring physiological and physical signals, but this is clearly not a solution for everyday clothing and, in particular, sleepwear.”

“We expect that these advances can be particularly useful for monitoring elderly patients, many of whom suffer from sleep disorders,” says Andrew. “Current generation wearables, like smartwatches, are not ideal for this population since elderly individuals often forget to consistently wear or are resistant to wearing additional devices, while sleepwear is already a normal part of their daily life. More than that, your watch can’t tell you which position you sleep in, and whether your sleep posture is affecting your sleep quality; our Phyjama can.”

This work was enhanced by Ganesan and Andrew’s affiliation with UMass Amherst’s Institute of Applied Life Sciences (IALS), which focuses on translating life science research into products that improve human health. Director Peter Reinhart at IALS says, “It’s exciting to see the next generation of wearable technology that is zero effort and addresses the issue of comfort and unobtrusiveness head-on. The data generated by fabric-based sensors have the potential to improve health and well-being, and could possibly contribute to the early diagnosis of multiple disorders.”

Thayumanavan Awarded Distinction by Board of Trustees

Sankaran ‘Thai’ Thayumanavan was appointed as a Distinguished Professor by the Board of Trustees. The title Distinguished Professor is conferred on select, highly accomplished faculty who have already achieved the rank of professor and who meet a demanding set of qualifications.

Chancellor Kumble Subbaswamy and Provost John McCarthy wrote,“Professor Thayumanavan’s research is focused on the design and synthesis of supramolecular assemblies with novel functions that advance chemical, materials and biological sciences in applications that range from molecular recognition to drug delivery to renewable energy. His work is distinguished by a focus on dynamics, creating materials with the ability to respond across multiple length and time scales and following exposure to stimuli including pH, temperature, and light.

He currently has grants that run several years into the future: an NIH grant with a 1.0 percentile score (amazing), an NSF grant as a CCI, an ARO MURI grant, and several other federal funded applications that are still running (an NIH R01, industrial sponsors) and many previous grants. This alone shows the longevity of his program and argues strongly for continued productivity.

Prof. Thayumanavan’s research program is characterized by prolific excellence. Since promotion to Professor in 2008, Prof. Thayumanavan has published over 120 articles, with more than 30 in the top tier of chemistry journals as lead author. In the same time period, he has garnered more than $26 million in external support. He has given more than 100 presentations on his research since 2008, including keynote addresses and prestigious lectures such as the Nanqiang lecture in Xiamen University (2014), and he was elected as a Fellow of the American Association for the Advancement of Science in 2011.”

Capturing Waste Heat Energy with Improved Polymers

A team led by UMass chemist Dhandapani Venkataraman, “DV,” and electrical engineer Zlatan Aksamija, reported in Nature Communications on an advance they outline toward more efficient, cheaper, polymer-based harvest of heat energy. “It will be a surprise to the field,” DV predicts, “it gives us another key variable we can alter to improve the thermo-electric efficiency of polymers. This should make us, and others, look at polymer thermo-electrics in a new light.” Aksamija explains, “Using polymers to convert thermal energy to electricity by harvesting waste heat has seen an uptick in interest in recent years. Waste heat represents both a problem but also a resource; the more heat your process wastes, the less efficient it is.”

DV and his chemistry PhD student Connor Boyle, with Aksamija and his electrical engineering Ph.D. student Meenakshi Upadhyaya worked in what DV calls “a true collaboration,” where each insight from numerical simulations informed the next series of experiments, and vice versa. The team turned to chemist Michael Barnes, a co-author on their recent paper, who used Kelvin Probe Force Microscopy to probe the dopants at the nano level and show that clustering is indeed present in polymers doped at room temperature, but not at higher temperatures.

The findings should provide a new path for designing more efficient polymers for thermo-electric devices. DV notes that until now, chemists and materials scientists have been trying to organize polymers to be more like the inorganics, “nicely aligned and very regular, which is difficult to do,” he adds. “It turns out that this may not be the way to go; you can take another road or another approach. We hope this paper provides a basis to move polymer-based thermo-electrics forward.”

Trisha Andrew Developed Smart Pajamas to Gather Information While You Sleep

The American Chemical Society showcased the ‘Phyjama’ developed by Trisha L. Andrew, chemistry, and presented at the ACS Spring 2019 National Meeting & Exposition. The ‘smart’ pajamas include monitors to help track sleep patterns, and could be available to consumers within a few years.

"Our smart pajamas overcame numerous technical challenges," says Trisha L. Andrew, Ph.D., who led the team. "We had to inconspicuously integrate sensing elements and portable power sources into everyday garments, while maintaining the weight, feel, comfort, function and ruggedness of familiar clothes and fabrics. We also worked with computer scientists and electrical engineers to process the myriad signals coming from the sensors so that we had clear and easy-to-understand information." 

Getting enough quality sleep can help protect people against stress, infections and multiple diseases, such as heart and kidney disease, high blood pressure and diabetes, according to the National Institutes of Health. Studies have found that quality sleep also increases mental acuity and sharpens decision-making skills. Yet most people do not get enough sleep — or the right kind. 

Vachet Receives CNS Outstanding Research Award

"Vachet’s interdisciplinary research program is at the interfaces of analytical, biological, and materials chemistry. He and his research group develop and apply new methods based on mass spectrometry to tackle biomedically important problems that are difficult to address with existing tools. His work has elucidated the molecular details associated with protein amyloid fibril formation, which is a special type of protein aggregation that occurs in numerous human diseases. His research has also led to the development of sensitive new methods to track nanomaterial drug delivery vehicles in biological systems, facilitating the creation of better therapeutics with fewer side effects." 

Award recipients are chosen by committees chaired by designees appointed by  Dean Tricia Serio, including past recipients. Dean Serio,  associate dean for research and innovation Mark Tuominen, and department representatives congratulated the winners, each speaking briefly about their experiences. 

Vicki Hubby Receives the CNS Outstanding Staff Award

"Vicki’s performance has been outstanding by any measure. She is considered the go-to person for many issues, including financial, compliance, and more. She is intelligent, efficient, always cheerful, and can be relied upon to solve any problem. She is indispensable and irreplaceable in that she almost single-handedly oversees all financial operations of our department, and is, in fact, the only person who fully understands them. "   Serio emphasized her gratitude to the award winners for their extraordinary work, presenting them as leaders for the college. “Their tremendous work continues to foster student achievement, demonstrate excellence, and build a more inclusive environment,” she said. “They are wonderful role models for us all.”  Friends, family, and colleagues gathered at a reception and awards ceremony May 14 for this year’s recipients of the CNS Outstanding Achievement Awards. The awards recognize faculty, staff and students who have made important contributions to their discipline, department, college and university.

Mahoney Seminar Thursday, Sept 19th, Prof. George M. Church

George M. Church, PhD ’84, is professor of genetics at Harvard Medical School, a founding member of the Wyss Institute, and director of PersonalGenomes.org, the world’s only open-access information on human genomic, environmental, and trait data. Church is known for pioneering the fields of personal genomics and synthetic biology. He developed the first methods for the first genome sequence & dramatic cost reductions since then (down from $3 billion to $600), contributing to nearly all “next generation sequencing” methods and companies. His team invented CRISPR for human stem cell genome editing and other synthetic biology technologies and applications – including new ways to create organs for transplantation, gene therapies for aging reversal, and gene drives to eliminate Lyme Disease and Malaria. Church is director of IARPA & NIH BRAIN Projects and National Institutes of Health Center for Excellence in Genomic Science. He has coauthored 450 papers, 105 patents, and one book, “Regenesis”. His honors include Franklin Bower Laureate for Achievement in Science, the Time 100, and election to the National Academies of Sciences and Engineering.

His talk "Synthesis & Analysis of Biopolymers" will be held on Thursday, September 19th at 11:30 in LGRT 1634.

Abstract: We have improved technologies for reading and writing nucleic acid and proteins 10 million fold since 2001. We can design and test millions to trillions of engineered genomes, gene therapy capsids, and combinatorial protein mixtures. But this progress is not limited to linear polymers nor to biology, but enables analysis, synthesis, and high throughput functional testing of a variety of complex, yet atomically precise 3D structures including novel chiralities, high density data storage, nanopores etc.

Stein-Covestro Seminar Thursday, Sept 5th, Prof. Timothy P. Lodge

Tim Lodge graduated from Harvard in 1975 with a B.A. cum laude in Applied Mathematics. He completed his PhD in Chemistry at the University of Wisconsin in 1980, and then spent 20 months as a National Research Council Postdoctoral Fellow at NIST. Since 1982 he has been on the Chemistry faculty at Minnesota, and in 1995 he also became a Professor of Chemical Engineering & Materials Science. In 2013 he was named a Regents Professor, the University’s highest academic rank.

His talk “Ionic Liquid/Block Polymer Nanostructures: Remarkably Versatile, Functional Materials” will be on Thursday, September 5th at 11:30 in LGRT 1634.

Abstract: Ionic liquids are an emerging class of solvents with an appealing set of physical attributes. These include negligible vapor pressure, impressive chemical and thermal stability, tunable solvation properties, high ionic conductivity, and wide electrochemical windows. In particular, the non-volatility renders ionic liquids practical components of devices, but they require structure-directing agents to become functional materials. Block polymers provide a convenient platform for achieving desirable nanostructures by self-assembly, with lengthscales varying from a few nanometers up to several hundred nanometers. Furthermore, ionic liquids and polymer blocks can be selected to impart exquisitely tunable thermosensitivity, by exploiting either upper or lower critical solution transitions (UCSTs and LCSTs). In selected cases, it is also possible to prepare photoreversible and photopatternable systems. Overall, by combining designed block polymers and ionic liquids we have demonstrated materials with superior performance for a remarkably diverse set of applications. These include gate dielectrics in organic transistors, electrochromic and electroluminescent gels, and membranes for gas separation, ion batteries, and fuel cells.

Gierasch Elected to National Academy of Sciences

The U.S. National Academy of Sciences announced this week the election of 100 new members to the academy in recognition of their distinguished and continuing achievements in original research. They include Lila M. Gierasch, distinguished professor of biochemistry and molecular biology and chemistry at the University of Massachusetts Amherst.

The NAS is charged with providing independent, objective advice to the nation on matters related to science and technology. Scientists are elected by their peers to membership in the NAS for outstanding contributions to research. Gierasch’s research focus for decades has been protein folding, that is, how amino acid sequence determines the three-dimensional structure of a protein. She is particularly focused on how proteins fold in the cellular environment and the role of molecular chaperones in ensuring high fidelity in the folding process.

She says of her selection, “I am thrilled by this honor. The recognition of one’s contributions over a career by colleagues is truly gratifying.”

John McCarthy, UMass Amherst provost and senior vice chancellor for academic affairs, says of Gierasch’s career accomplishments, “This is a richly deserved honor for one of our stellar faculty members. Lila Gierasch is part of what makes this university great.”

The National Academy of Sciences (NAS) is a private, non-profit society of distinguished scholars established by an Act of Congress signed by President Abraham Lincoln in 1863. The academy is charged with providing independent, objective advice to the nation on matters related to science and technology. Scientists are elected by their peers to membership in the NAS for outstanding contributions to research.

S. "Thai" Thayumanavan awarded the 2019 Mahoney Life Sciences Prize

S. ‘Thai’ Thayumanavan, professor of chemistry is awarded the Mahoney Life Sciences Prize for his paper: “Shrink-wrapped Proteins as Next Generation Biologics.” Thayumanavan’s work addresses major challenges in delivering protein-based drugs and devices across a cell membrane while keeping the protein stable and avoiding unwanted immune system responses. The award-winning study presents a “robust and sustainable” strategy which overcomes those challenges: the protein itself serves as a template, and polymers self-assemble to form a sheath around it. The technology has exciting potential applications in therapeutics.

The panel of expert judges praised Thayumanavan’s work as “a major step forward that takes on a long-standing problem,” and “a large advance in the field.” Tricia Serio, dean of the College of Natural Sciences said, “Thai’s approach — to have the protein template its own packaging — is the type of innovative and out-of-the-box thinking that enables transformational advances in science. His work embodies the spirit of this award.”

Richard Vachet, chemistry department head, said, "Thai is a very creative scientist who has a remarkable ability to turn fundamental chemical understanding into new materials that solve real-world problems in biomedicine. His work is a great example of how UMass Amherst researchers are doing translational research."

Through the generosity of the Mahoney family, the prize recognizes UMass Amherst scientists whose work has the potential for advancing connections between research and industry. The Prize includes an award of $10,000 and is awarded annually to one faculty member who has demonstrated excellence in life sciences research, and whose work significantly advances connections between academic research and industry.

Riddha Das won 3MT People’s Choice Award

Riddha Das, a doctoral student in chemistry, won the 3MT People’s Choice Award. “It was very difficult to condense five or six years of research into three minutes,” she said, “but now if I’m at an interview or a conference, I don’t have to stumble or wonder where to begin.” Das’s research focuses on using nanoparticles to fight cancer.

Organized by the Graduate School’s Office of Professional Development, the annual three-week-long contest tests the research communication skills of 40 doctoral and master’s students by challenging them to explain the significance of their academic projects in accessible and compelling presentations of three minutes or less.

The finalists presented their talks at a public event at Amherst’s Jones Library on March 23.

Gov. Charlie Baker Celebrates Opening of Physical Sciences Building

Gov. Charlie Baker celebrated the opening of the new Physical Sciences Building (PSB) at the University of Massachusetts Amherst, a facility funded by the state that fosters and expands cutting-edge collaborative learning and research at the Commonwealth’s flagship campus.

“We were pleased to invest in the new Physical Sciences Building, which will serve as a hub for the natural sciences at UMass Amherst,” Baker said. “The facility’s expansion will help foster new research and career opportunities, which will help support the STEM workforce pipeline here in Massachusetts.”

Chancellor Kumble Subbaswamy says, “This complex is home to the very best facilities in physics and chemistry, enhancing the research capability for our faculty and students in the College of Natural Sciences and providing the STEM talent that is essential for the state’s innovation economy. We’re deeply grateful for the governor’s support and the state’s investment in UMass Amherst.”

“This project reflects the significance of the Commonwealth’s investment in faculty excellence, scientific discovery and student success at UMass Amherst,” said UMass President Marty Meehan. “And it strengthens UMass Amherst’s position as a top-tier public research university that prepares students to thrive in the high-demand STEM fields that are so important to the future of Massachusetts.”

Pages