The University of Massachusetts Amherst

Cell Based Therapies

Minter and colleagues have developed humanized, lymphocyte transfer model of graft-versus-host disease and demonstrated that polymer antibody complexes can be readily introduced with high efficacy into hard-to-transfect human peripheral mononuclear blood cells, eliciting a biological response sufficient to alter disease progression (Mol. Ther. 2016, 24, 2118-2130).

Develop and utilize novel delivery technologies to modify cells that are used for a variety of therapies. Examples include ongoing work to modify bacteria to invade tumor tissue and deliver payloads designed to kill or arrest the growth of the tumor. Additionally, strategies are being developed to use delivery technologies to modify cells of the immune system for adoptive transfer into a syngeneic host. The aim is to develop efficient ex vivo approaches to manipulating cellular responses and utilize them in a variety of therapeutic approaches.

 
Contact Info

Neil Forbes, Chemical Engineering
(413) 577-0132
forbes@ecs.umass.edu

Ashish Kulkarni, Chemical Engineering
akulkarni@engin.umass.edu

Research Highlights