Todd Emrick
Professor; Director, Materials Research Science and Engineering Center
Research areas include synthetic organic and polymer chemistry, polymer therapeutics and prodrugs, polymer-DNA polyplexes for gene therapy.
Current Research
Our research program emphasizes the synthesis of new materials, including polymers, nanoscale particles, and polymer-drug conjugates that target a variety of applications in materials science and therapeutics. New synthetic methods are required to overcome limitations of conventional polymers and particles that can be purchased commercially. Our efforts have produced new functionalized materials that are tailored for interfacial assembly, biocompatibility, in vivo injectables, encapsulation, and controlled release.
Learn more at www.pse.umass.edu/~temrick/
Academic Background
- BS Juniata College, 1992
- PhD University of Chicago, 1997
- Postdoctoral training: University of California Berkeley, 1997-2000
Samanta, D; McRae, S; Cooper, B; Hu, Y; Emrick, T. “End-Functionalized Phosphorylcholine Methacrylates and their Use in Protein Conjugation” Biomacromolecules 2008, 9, 2891-2897.
Chen, X.J.; McRae, S.; Parelkar, S.; Emrick, T. “Polymeric Phosphorylcholine-Camptothecin Conjugates Prepared by Controlled Free Radical Polymerization and Click Chemistry” Bioconjugate Chemistry, 2009, 20, 2331-2341.
Joralemon, M.; McRae, S.; Emrick, T. “PEGylated Polymers for Medicine: from conjugation to self-assembled systems”, Chem. Commun. 2010, 46, 1377-1393.
Chen, XJ., Lawrence, J., Parelkar, S., Emrick, T. “Novel Zwitterionic Copolymers with Dihydrolipoic Acid: Synthesis and Preparation of Nonfouling Nanorods” Macromolecules, 2013, 1, 119-127.
McRae, S.; Chen, X.; Kratz, K.; Samanta, D.; Henchey, E.; Schneider, S.; Emrick, T. “Pentafluorophenylester-functionalized Phosphorylcholine Polymers: Preparation of Linear, Two-arm, and Grafted Polymer-Protein Conjugates” Biomacromolecules 2012, 13, 2099-2109.
Chen, X.; Parelkar, X.; Henchey, E.; Schneider, S.; Emrick, T. “PolyMPC-Doxorubicin Prodrugs” Bioconjugate Chemistry 2012, 23, 1753-1763.
Zolochevska, O.; Ellis,J.; Parelkar, S.; Chan-Seng, D.; Emrick, T.; Wei, J.; Patrikeev, I.; Motamed, M.; Figueiredo, M. Interleukin-27 gene delivery for modifying malignant interactions between prostate tumor and bone Human Gene Therapy 2013, 13, 970-981.
Page, S.M.; Henchey, E.; Chen X.; Schneider, S.; Emrick, T. Efficacy of PolyMPC-Dox Prodrugs in 4T1 Tumor-bearing Mice Molecular Pharmaceutics 2014, 11, 1715-1720.
