Jinging Gao

Assistant Professor

Research focuses on translational strategies to develop gene therapies for neurological disorders or chronic diseases.

Current Research

Working at the interface of material science, chemistry, biology, and biomedical engineering, Dr. Gao aims to promote healthy aging with a materials-centric approach and to innovate the treatments for degenerative diseases. Her research focuses on translational strategies to develop gene therapies for neurological disorders or chronic diseases. Ongoing research projects include 1) Nanoparticle-mediated brain mapping for precision gene therapy; 2) Gene therapy to modulate neuroinflammation; 3) Long-acting delivery of biologics for chronic disease.

The overarching goal of Dr. Gao's laboratory is to promote healthy aging through the innovative creation of drug delivery strategies that maximize the efficacies of biotherapeutics to slow down or stop the progression of degenerative diseases. By leveraging tools of organic chemistry, materials chemistry, micro/nano/macro fabrication, and understanding of tissue/cell-material interactions, she will focus on the delivery of gene therapies toward neurological disorders

Learn more at https://www.jingjinggaolab.com/

Academic Background

Postdoc, Harvard Medical School, 2023
PhD University of Massachusetts Amherst 2020
M.S. Shanghai Jiao Tong University 2014
B.S. South-central Minzu University 2011

Publications

Huynh, U.; Wu, P.; Qiu, J.; Prachyathipsakul, T.; Singh, K.; Jerry, D. J.; Gao, J.*; Thayumanavan, S*. Targeted Drug Delivery Using a Plug-to-Direct Antibody–Nanogel Conjugate. Biomacromolecules 2023, 24 (2), 849–857. https://doi.org/10.1021/acs.biomac.2c01269.

https://doi.org/10.1021/acs.biomac.2c01269

Gao, J.; Karp, M.J.; Langer, R.; Joshi, N. “The future of drug delivery”. Chemistry of Materials, 2022, 35 (2), 359-363. https://pubs.acs.org/doi/10.1021/acs.chemmater.2c03003

https://pubs.acs.org/doi/10.1021/acs.chemmater.2c03003

Gao, J.; Xia, Z.; Joseph, J.; Luo, J.; Joshi, N.“ Progress in non-viral localized delivery of siRNA therapeutics for pulmonary diseases”. Acta Pharmaceutica Sinica B, 2022, https://doi.org/10.1016/j.apsb.2022.07.010.

https://doi.org/10.1016/j.apsb.2022.07.010

Gao, J.; Dutta, K.; Zhuang, J.; Thayumanavan, S. “Cellular and subcellular targeted delivery using a simple all-in-one polymeric nanoassemblies.” Angew. Chem. Int. Ed. 2020, 132, 23672-23676.

Gao, J.; Wu, P., Fernandez, A, Zhuang, J.; Thayumanavan, S. “Cellular AND gates synergize to boost selective uptake of polymeric assemblies.” Angew. Chem. Int. Ed. 2020, 59, 10456-10460.

Jinging Gao

Institute for Applied Life Sciences