Jinging Gao

Assistant Professor

Research focuses on translational strategies to develop gene therapies for neurological disorders or chronic diseases.

Current Research

Working at the interface of material science, chemistry, biology, and biomedical engineering, Dr. Gao aims to promote healthy aging with a materials-centric approach and to innovate the treatments for degenerative diseases. Her research focuses on translational strategies to develop gene therapies for neurological disorders or chronic diseases. Ongoing research projects include 1) Nanoparticle-mediated brain mapping for precision gene therapy; 2) Gene therapy to modulate neuroinflammation; 3) Long-acting delivery of biologics for chronic disease.

The overarching goal of Dr. Gao's laboratory is to promote healthy aging through the innovative creation of drug delivery strategies that maximize the efficacies of biotherapeutics to slow down or stop the progression of degenerative diseases. By leveraging tools of organic chemistry, materials chemistry, micro/nano/macro fabrication, and understanding of tissue/cell-material interactions, she will focus on the delivery of gene therapies toward neurological disorders

Learn more at https://www.jingjinggaolab.com/

Academic Background

  • Postdoc, Harvard Medical School, 2023
  • PhD University of Massachusetts Amherst 2020
  • M.S. Shanghai Jiao Tong University 2014
  • B.S. South-central Minzu University 2011
Huynh, U.; Wu, P.; Qiu, J.; Prachyathipsakul, T.; Singh, K.; Jerry, D. J.; Gao, J.*; Thayumanavan, S*. Targeted Drug Delivery Using a Plug-to-Direct Antibody–Nanogel Conjugate. Biomacromolecules 2023, 24 (2), 849–857. https://doi.org/10.1021/acs.biomac.2c01269.
Gao, J.; Karp, M.J.; Langer, R.; Joshi, N. “The future of drug delivery”. Chemistry of Materials, 2022, 35 (2), 359-363. https://pubs.acs.org/doi/10.1021/acs.chemmater.2c03003
Gao, J.; Xia, Z.; Joseph, J.; Luo, J.; Joshi, N.“ Progress in non-viral localized delivery of siRNA therapeutics for pulmonary diseases”. Acta Pharmaceutica Sinica B, 2022, https://doi.org/10.1016/j.apsb.2022.07.010.
Gao, J.; Dutta, K.; Zhuang, J.; Thayumanavan, S. “Cellular and subcellular targeted delivery using a simple all-in-one polymeric nanoassemblies.” Angew. Chem. Int. Ed. 2020, 132, 23672-23676.
Gao, J.; Wu, P., Fernandez, A, Zhuang, J.; Thayumanavan, S. “Cellular AND gates synergize to boost selective uptake of polymeric assemblies.” Angew. Chem. Int. Ed. 2020, 59, 10456-10460.
Contact Info

Biomedical Engineering

Office: (413) 545-8893
Email: jgao@umass.edu