The University of Massachusetts Amherst

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Research Themes

Cell Based Therapies

Develop and utilize novel delivery technologies to modify cells that are used for a variety of therapies. Examples include ongoing work to modify bacteria to invade tumor tissue and deliver payloads designed to kill or arrest the growth of the tumor. Additionally, strategies are being developed to use delivery technologies to modify cells of the immune system for adoptive transfer into a syngeneic host. The aim is to develop efficient ex vivo approaches to manipulating cellular responses and utilize them in a variety of therapeutic approaches.

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Minter and colleagues have developed humanized, lymphocyte transfer model of graft-versus-host disease and demonstrated that polymer antibody complexes can be readily introduced with high efficacy into hard-to-transfect human peripheral mononuclear blood cells, eliciting a biological response sufficient to alter disease progression (Mol. Ther. 2016, 24, 2118-2130).

Research Highlight

Innovation / Technology

Fundamental & Applied Research in RNA Synthesis

Exploit decades of mechanistic understandings to develop new routes to synthesis of RNA in high yield and purity Specifically, develop approaches targeting mRNA vaccines and therapeutics, CRISPR therapies and technologies, and advances in long noncoding RNAs, with a particular eye towards inexpen

The standard enzymatic batch synthesis models of RNA production contribute to lower yields and purity than the enzyme is capable of producing.

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