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Research Themes
Combinations and Interfaces
CBD recognizes enormous opportunities at the interface of these cargo classifications. For example, combination of small molecule encapsulation with antibodies provide opportunities in developing innovative and impactful alternates to antibody-drug conjugates (ADCs) (Bioconjugate Chem. 2015, 26, 2198–2215). Similarly, combining the delivery of proteins and nucleic acids present opportunities in novel cell-based therapies, including in genome editing strategies such TALEN and CRISPR. CBD investigators are collaboratively targeting these opportunities at the interface of different technology platforms and cargoes.
Research Highlight
Innovation / Technology
Exploiting Apoptotic Caspases for targeted cell death via Intracellular Delivery
How many active caspases does it take to induce apoptosis? Do pro-survival and pro-apoptotic intracellular balances influence a caspase’s ability to induce cell death (i.e. potency)?
Cysteine aspartate proteases (caspases) act as the molecular scissors of apoptotic cell death, disintegrating diverse cellular components necessary for cell survival and growth.
