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Research Themes
Cell Based Therapies
Develop and utilize novel delivery technologies to modify cells that are used for a variety of therapies. Examples include ongoing work to modify bacteria to invade tumor tissue and deliver payloads designed to kill or arrest the growth of the tumor. Additionally, strategies are being developed to use delivery technologies to modify cells of the immune system for adoptive transfer into a syngeneic host. The aim is to develop efficient ex vivo approaches to manipulating cellular responses and utilize them in a variety of therapeutic approaches.
Research Highlight
Innovation / Technology
Fundamental & Applied Research in RNA Synthesis
Exploit decades of mechanistic understandings to develop new routes to synthesis of RNA in high yield and purity Specifically, develop approaches targeting mRNA vaccines and therapeutics, CRISPR therapies and technologies, and advances in long noncoding RNAs, with a particular eye towards inexpen
The standard enzymatic batch synthesis models of RNA production contribute to lower yields and purity than the enzyme is capable of producing.
