Develop robust capabilities to deliver peptides, proteins, and antibodies to targeted cells and tissues. The team is tackling the challenge of protecting protein-based biologics from protease degradation and deliver them to targeted cells and tissues, and also to specific intracellular compartments. These approaches open up opportunities in “undruggable” targets such as targeting K-Ras and in enhancing the efficiencies of protein-based therapies such as in lysosomal storage diseases.
We developed an innovative strategy to use cell-penetrating peptide mimics – synthetic peptides designed to carry biological cargo across a cell membrane – to deliver functional antibodies into human immune cells to instill long-lasting changes to cellular behavior.