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Research Themes

Cell Based Therapies

Develop and utilize novel delivery technologies to modify cells that are used for a variety of therapies. Examples include ongoing work to modify bacteria to invade tumor tissue and deliver payloads designed to kill or arrest the growth of the tumor. Additionally, strategies are being developed to use delivery technologies to modify cells of the immune system for adoptive transfer into a syngeneic host. The aim is to develop efficient ex vivo approaches to manipulating cellular responses and utilize them in a variety of therapeutic approaches.

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Minter and colleagues have developed humanized, lymphocyte transfer model of graft-versus-host disease and demonstrated that polymer antibody complexes can be readily introduced with high efficacy into hard-to-transfect human peripheral mononuclear blood cells, eliciting a biological response sufficient to alter disease progression (Mol. Ther. 2016, 24, 2118-2130).

Research Highlight

Innovation / Technology

Drugging the Undruggable

Cell-penetrating peptide mimics deliver functional antibodies across cell membranes to generate super-suppressive regulatory T cells for use as a cell-based therapy

We developed an innovative strategy to use cell-penetrating peptide mimics – synthetic peptides designed to carry biological cargo across a cell membrane – to deliver functional antibodies into human immune cells to instill long-lasting changes to cellular behavior.

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Graphical representation of the process, application, and efficacy of using cell-penetrating peptide mimics to deliver antibodies specific for phosphorylated into human CD4 T cells to generate a highly suppressive cell-based therapy to attenuate Graft-vs-Host disease.