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Research Themes

Proteins, Peptides & Antibodies

Develop robust capabilities to deliver peptides, proteins, and antibodies to targeted cells and tissues. The team is tackling the challenge of protecting protein-based biologics from protease degradation and deliver them to targeted cells and tissues, and also to specific intracellular compartments. These approaches open up opportunities in “undruggable” targets such as targeting K-Ras and in enhancing the efficiencies of protein-based therapies such as in lysosomal storage diseases.

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Thayumanavan group has developed a novel first-principle strategy to shrink-wrap proteins, protect them proteases, deliver to cells, and trigger the traceless of proteins in response to a specific intracellular trigger. Image shows the delivery of proteins to activate molecular homing in the nucleus (J. Am. Chem. Soc. 2017, 139, 5676).

Research Highlight

Innovation / Technology

Drugging the Undruggable

Cell-penetrating peptide mimics deliver functional antibodies across cell membranes to generate super-suppressive regulatory T cells for use as a cell-based therapy

We developed an innovative strategy to use cell-penetrating peptide mimics – synthetic peptides designed to carry biological cargo across a cell membrane – to deliver functional antibodies into human immune cells to instill long-lasting changes to cellular behavior.

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Graphical representation of the process, application, and efficacy of using cell-penetrating peptide mimics to deliver antibodies specific for phosphorylated into human CD4 T cells to generate a highly suppressive cell-based therapy to attenuate Graft-vs-Host disease.