PhD: Yale University
Postdoctoral training: University of Pennsylvania & Pennsylvania State University
High-Throughput Screening (HTS) is a pharmaceutical industry standard for the discovery of drugs with new or improved properties that is now increasingly being implemented in academic settings as well. Miniaturization of bioassays and development in sensitive and rapid detection instrumentation permit thousands of compounds to be assayed for a desired function in vitro, in cellulo and even in vivo, while reducing the costs to the researchers. When integrated with modeling and/or cheminformatics, the number of compounds that needs to be evaluated could be reduced significantly by in silico methods to make screening a reasonable and, yet, powerful option for chemical probe/drug discovery in an academic setting, where resources could be limited.
As a liaison between the Small Molecule Screening Facility at UMMS and the UMass Amherst campus, I intend to identify venues for complementary and mutually beneficial collaborations and thoroughly assist in their implementation. Toward this goal, I plan to acquire and curate a 100,000-compound library that can be formatted for both drug discovery and drug development needs of UMass researchers. In addition, I am offering integrated cheminformatic and computational modeling services for the purpose of discovery and further elaboration of discovered chemotherapeutics. Specifically, I plan to assist researchers across campus with thorough analyses of HTS results and various associated computational needs, including cheminformatic, modeling, docking, and dynamic simulation methods.
Figure 1. Integrated tools for the discovery/optimization of cellular probes and drugs
Eissler, C.L., Mazón G., Powers B.L., Savinov S.N., Symington L.C., Hall M.C. The cdk/cdc14 module controls activation of the yen1 holliday junction resolvase to promote genome stability. Mol Cell. 2014, 54, 80-93.[PubMed]
Eggler, A.L., Savinov S.N. Chemical and Biological Mechanisms of Phytochemical Activation of Nrf2 and Importance in Disease Prevention. Rec Adv Phytochem 2013, 43, 121–155.
Verhoeven K.D., Altstadt O.C., Savinov S.N. Intracellular Detection and Evolution of Site-Specific Proteases Using a Genetic Selection System. Appl Biochem Biotechnol 2012, 166, 1340–1354. [PubMed]
Datta S., Bucks M.E., Koley D., Lim P.X., Savinov S.N. Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system. Bioorg Med Chem 2010, 18, 6099–6108. [PubMed]
Bucks M.E., Savinov S.N. Direct evaluation of cellular internalization rates using chromogenic disulfides. Mol Biosyst 2010, 6, 1176–1179. [PubMed]