U.S. Veterinary Immune Reagent Network

Equine

Progress

Gene Sequences

Comparative Alignments

Primers

Bioassays

References for Genes

Posters

Commercially Available Reagents

Recombinant proteins will be made for the following genes: CCL2, CCL3, CCL5, CCL11, CXCL9, CXCL10, GM-CSF, IFN-γ, IFN-α1, IL-1β, IL-2, IL, 4, IL-6, IL-10, IL-12p35, IL-12p40, IL-13, IL-15, IL-17, IL-18, IL-23, TGFβ, TNF-α

Monoclonal antibodies will be made to:

Cell Surface Molecules:

CD25: monoclonal fusion completed May 2008 (Cornell); 1 mAb, became negative, will repeat fusion (Cornell)

CD40: monoclonal fusion completed September 2008 (UMass Amherst); many positives currently in testing (Cornell)

CD23: monoclonal fusion completed October 2008 (Cornell); 6 mAbs, contact Dr. Bettina Wagner, Cornell

CD28: monoclonal fusion completed November 2008 (Cornell); 3 mAbs, contact Dr. Bettina Wagner, Cornell

FcεRIα: fusion completed (Cornell); 3 mAbs, contact Dr. Bettina Wagner, Cornell

TCRα: protein production planned June 2009; monoclonal antibody production planned July 2009 (Cornell)

TCRγ: re-cloning into IL-4 vector (Cornell); fusion scheduled July 2009 (Cornell)

TCRδ: protein production planned June 2009 (Cornell); monoclonal antibody production planned July 2009 (Cornell)

IgD: protein production planned June 2009 (Cornell); monoclonal antibody production planned July 2009 (Cornell)

Cytokines and Chemokines:

IL-4: protein production planned November 2008 (Kingfisher); monoclonal antibody production planned Decemeber 2008 (Cornell)

IL-2: protein production planned March 2009 (Kingfisher); monoclonal antibody production planned April 2009 (Cornell)

IL-6: protein production planned April 2009 (Kingfisher); monoclonal antibody production planned May 2009 (Cornell)

IL-8: no mAbs despite 3 fusions

Click here for a list of equine reagents currently available: http://www.ca.uky.edu/Gluck/HorohovDW_EIR.asp.

Click here to download the survey form.
Then fill it out, and send it back to the appropriate species coordinator.

Last updated: August 2009