Graduate Program in Animal Biotechnology & Biomedical Sciences

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Degrees Offered, Research Opportunities, and Program Goals
Program Requirements
Student Life: The University and its Environs
Financial Aid
Application and Admission to the Program
Interdepartmental Graduate Programs
Equipment and Facilities

Degrees Offered, Research Opportunities, and Program Goals

The Animal Biotechnology and Biomedical Sciences graduate program is offered through the Department of Veterinary and Animal Sciences and may lead to:

  • Master of Science with thesis
  • Master of Science without thesis
  • Doctor of Philosophy (Ph.D.)

Our program emphasizes learning and research in four main areas: (i) immunology and infectious diseases, (ii) developmental and reproductive physiology, (iii) gene expression and its role in health and disease, and (iv) toxicology. The departmental program currently offers opportunities for research in:

  • Cellular immunology
  • Resistance to protozoan infections
  • Resistance to bacterial infections
  • Immunogenetics of antibody diversity
  • Cell death in lymphocytes
  • Gene regulation in developmental immunology
  • Oogenesis and signaling in oocytes
  • Developmental biology, including follicular development, embryo culture, stem cells
  • Control of fertility
  • Signaling pathways in sperm capacitation
  • Regulation of gene expression
  • Genetic modification of domestic animals
  • Genetic control of obesity
  • Genetic models made by gene knock-out
  • Genetic control of cell transformation (cancer)
  • Toxicology and reproduction
  • Neurotoxicology and pharmacology of pesticides
  • Drug resistance mechanisms to pesticides


The Program's goals are to:

  • Prepare scientists to work productively in the emerging fields of animal biotechnology and biomedicine by providing them with experience in hypothesis formulation, problem solving and research technique development.
  • To produce research that results in increased understanding of disease processes, control of disease, reproduction and development, development of new animal models or animals with new genetic capabilities, and effect of toxins on animal and human health and on control of disease caused by ectoparasites.
  • To instill in students an understanding of research and the exploration of the unknown.


The strength of the research graduate program is the active core of faculty who are strongly committed to quality graduate education. The close and active collaborations among the faculty broaden and strengthen the learning environment for graduate students. The involvement of the faculty with interdisciplinary programs on campus brings a wide variety of students to our laboratories and seminars that enhance the discussion and promotes close interactions amongst a wide variety of students. The faculty attract post-doctoral fellows from around the world and their presence invigorates the research enterprise. Thus students do not work in isolation and are part of both the wider departmental program as well as interdepartmental program communities on campus including the Molecular and Cellular Biology Program (see below) as well as Neuroscience and Behavior Program and the Collaborative Biomedical Research Program at Baystate Medical Center in Springfield, MA (about 14 miles from Amherst).

Research in the Animal Biotechnology and Biomedical Sciences graduate program is supported by a variety of sources. Faculty hold grants from the United States Department of Agriculture, the National Institutes of Health, the National Science Foundation, the United States Agency for International Development as well as from private industry, foundations and the Massachusetts Agricultural Experiment Station. These funds provide the basis of graduate student financial support.

Our graduate students continue to be placed advantageously in excellent career situations and post-doctoral positions around the nation. Biotechnology and biomedical institutes and companies realize the value of incorporating into their organizations biotechnologists who have expertise in the physiology, management and manipulation of domestic animals as well as a thorough knowledge of cellular and molecular biology.

Program Requirements

See the Graduate Handbook for details on program requirements, courses, rules and milestones.

The main emphasis of the graduate program is to gain a grasp of research by learning to formulate hypotheses and design experiments to address them as well as to prepare the results for publication. However, students supplement this with a variety of formal graded course work as well as by attending research seminars by renowned speakers and journal clubs that review current research literature. All graduate students attend the research seminars each semester during their tenure in the department as well as a journal club that reviews current published papers.

For the Masters and Ph.D., 15 credits of course work are required and include seminar (1 credit each semester) and journal club (1 credit each semester) as well as one course in biostatistics (3 credits). Key courses essential to training in the general discipline of biology with an emphasis on biochemistry and molecular and cellular biology are encouraged to meet the credit requirements. The departmental faculty offer advanced courses as well as fundamental courses that carry graduate credit in immunology and infectious diseases, as well as cells, genes and developmental biology. Thesis research credits make up the requirement of 30 credits for the masters degree while 18 dissertation credits are required for the Ph.D. Non-thesis masters degree students register for independent studies to cover the research/laboratory work to obtain a total of 30 credits. Ph.D. students also must pass a written and oral qualifying exam that normally takes the form of a mock grant proposal and oral defense of it. Both Ph.D. and M.S. students must pass a final exam focused on their research work. All graduate students form an advisory committee of at least 3 faculty members who meet regularly with the student to assess progress and offer advice.

The fifth year Masters is for students who are undergraduates in the department and begin research in a laboratory usually by the second semester of their junior year. During their senior year they develop their research skills and take 6 credits of coursework at or above the 500 level and beyond that required for the B.S. degree. To complete the Masters requires 12-15 months after the B.S. degree and includes a combination of research work for independent study credit and 6-8 additional coursework credits, as well as attending Department seminars and journal club.

Financial Aid

Students (U.S. citizen and foreign) are eligible for research or teaching assistantships. Except for non-thesis masters students, graduate students accepted into the program are provided with financial support from individual faculty members (that is, the research supervisor). Research assistantships and teaching assistantships that are on full-time renumeration receive approximately $17,000/year as a salary stipend in addition to tuition, curriculum fees and medical insurance for a total combined value of on average ~$25,000/year. Students must pay their own program fees which range from $100-$500/year. Students admitted to the program are responsible for finding their own transport to and from Amherst, Massachusetts. Foreign students must remain registered as full-time students during their stay to maintain visa status. There are also competitive fellowships available from the Graduate School and other bodies in addition to the R.A. and T.A. positions.

Application and Admission to the Program

Applications deadlines set by the Graduate School are February 1 for admission in September and October 1 for admission in January. However the department operates under a rolling admissions system which means that students may apply and the applications may be reviewed at any time. Students may also opt to begin their studies in the summer semester. Masters with thesis and Ph.D. students are accepted by individual faculty members directly into their laboratories, that is, students generally do not undertake laboratory rotations. Thus students are encouraged to contact individual faculty members about their research programs and the availability of space and financial support in their laboratory.

Applications must include a completed application form, two letters of recommendation and completion of the Graduate Record Examination (GRE). Foreign students not from an English-speaking country (i.e., one whose national language is English) must also take the Test of English as a Foreign Language (TOEFL) and score at least 550. This includes students from non-English speaking countries even though their degrees may have been awarded in English.

Applications are available online at or can be obtained from the address below. For general information, visit the UMass Graduate School web site. Students interested in particular research labs should contact the individual faculty member.

To check on status of your application, please contact Program Coordinator:

Graduate Program Coordinator
Mary Schneider

309 Stockbridge Hall
University of Massachusetts
Amherst, Massachusetts 01003
email: mschneider@vasci.umass.edu

For inquiries about the program itself:


Graduate Program Director
Dr. Pablo Visconti
Department of Veterinary and Animal Sciences
208 Paige Laboratory
University of Massachusetts
Amherst, Massachusetts 01003
email: pvisconti@vasci.umass.edu

Interdepartmental Graduate Programs

Students can major in the departmental graduate program (Animal Biotechnology and Biomedical Sciences) in conjunction with one of the following interdepartmental programs. To do so, the student must be admitted to the interdepartmental program and meet the requirements for both the departmental and interdepartmental programs (many of which are overlapping). Interdepartmental programs which our students may be interested in include:

Students can also benefit from the Collaborative Biomedical Research Program.

Equipment and Facilities

Facilities

The Animal Biotechnology and Biomedical Sciences graduate program is housed principally in Paige Laboratory, a classically styled building that has been renovated into a modern research facility. There are laboratories equipped to do tissue culture, micromanipulation of cells and nuclei, protein purification, genetic engineering/molecular biology and flow cytometry. A Biohazard Level 3 laboratory for working with infectious organisms is also available as are laboratories for working with hazardous chemicals. Adjacent to Paige Laboratory is the recently renovated Thayer building, which is a USDA approved research animal house. It includes a Biohazard level 3 animal room and facilities for small animals (rodents) such as those that are immunocompromised or transgenic. There are three field stations available to the program for animal housing including Hadley Farm (horses, cattle, goats, swine and sheep), South Deerfield (cattle and swine) and Tilson Farm (poultry). The Hadley Farm contains field laboratory facilities for doing reproduction research with horses. The South Deerfield farm was set up as a modern dairy operation with facilities for sterile embryo collection, large animal surgery, as well as laboratories for embryo manipulation that includes laminar flow hoods and micromanipulators. Tilson Farm has facilities for handling small numbers of poultry and has barns that are used for larger scale experiments with small domestic animals.

General Equipment

The Department has a large volume of equipment needed for most molecular and cellular experimentation including:

  • Real-time PCR Light cycler; PCR thermocyclers;
  • Computerized ELISA reader for kinetic and temperature controlled assays;
  • Spectrophotometer for kinetic and temperature controlled assays;
  • HPLC;
  • Histology equipment (Leica CM3050 cryostat and Olympus microtomes;
  • Capillary gap tissue staining apparatus);
  • Tissue processing and embedding equipment (Microwave processor from Energy Beam Science; Embedding station from Tissue-Tek);
  • Digital imaging facility (Pentium computer, frame-grabbers, BioQuant image analysis software, SPOT II digital camera for white light and low level fluorescence, Photo quality dye sublimation color printer, Sony 7600, Zeiss microscope equipped with fluorescence and triple wavelength filters)and an inverted UV Nikon scope with 100X oil objective;
  • Piezoelectric unit for microinjection;
  • Transgenic and embryo cloning facilities;
  • Fluorometer;
  • Luminometer;
  • 137Cesium gamma-irradiator for cells;
  • Scintillation counter that detects gamma and beta emission;
  • Phosphorimager (Cyclone, Packard Instruments);
  • Chemiluminescence imaging system
  • Dell computer with a high speed color printer networked to offices and slide shooting capacity;
  • Projectors and laptop computers for Power Point presentations;
  • High speed bench centrifuge;
  • 3 super-speed floor centrifuges;
  • Ultracentrifuge;
  • Environmental shakers for bacteria;
  • Common -80 freezers;
  • Autoclaves;
  • Milli-Que water purification system;
  • Darkroom with automatic film processor;
  • flow cytometry is provided by a FACSCalibur, FACScan and FACStar.

Additional specialized equipment in individual labs available for use:

  • Automated cell harvester for radionucleotide incorporation assays;
  • fume hood with computerized air handling;
  • Homogenizer for cell membrane preparation;
  • FPLC located in 4C room; Rotophor cell;
  • Sonicator with cup horn or probe;
  • Phast gel system;
  • Cell microinjection (2 set-ups with Nikon Diaphot scopes with Narishige manipulators and picoinjectors; each equipped with Piezo drill (Burleigh) and fluorescence);
  • Ca2+ monitoring equipment (can be used with a photomuliplier (Phoscan 3) and with an imaging system, Universal Imaging);
  • UVP Gel documentation system;
  • Olympus bright-field microscope equipped with video camera and Pentium computer.

University facilities available through the MCB program include the following:

  • Automated DNA Sequencing Facility
  • Microscopy and Imaging Center
  • Genome Analysis and Computing
  • Transgenic Animals
  • High Field NMR Facility