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Mononucleosis

Infectious mononucleosis (mono) is common among college students. Caused by the Epstein-Barr virus (EBV), mono is spread through intimate contact with saliva – thus, the nickname “the kissing disease.” It’s unlikely to spread through casual contact. EBV isn’t transmitted through the air, so there’s no need to isolate someone with mono. The virus is often found in healthy people who’ve had mono in the past, but still carry and spread the illness.

The time from exposure to illness (the incubation period) ranges from four to six weeks. Early symptoms include fever, nausea, and headaches, usually followed by a severe sore throat and swollen neck glands. There can be a variety of other symptoms and sometimes unusual complications, but for most the illness is relatively mild and they recover in a couple of weeks. Some people experience significant fatigue during this time.

Treatment

  • Mono is caused by a virus, so antibiotics aren’t effective. Antibiotics are only used if a secondary bacterial illness develops.
  • The virus attacks lymphocytes, a type of white blood cell, which leads to inflammation of lymph nodes, the liver and spleen. Those with mono should avoid alcohol, which is metabolized in the liver, and contact sports, to prevent spleen injury.
  • For relief of sore throat pain, use over-the-counter analgesics such as Ibuprofen and frequent warm salt water gargles.
  • Extra rest and good hydration are essential.
  • Those with severely swollen tonsils or other serious complications are sometimes given a short course of steroids to suppress the inflammation.

Recovery

Most people recover from mono within 10 – 14 days; about a third of college students with the illness don’t even need bed rest. However, some people become quite ill and need several weeks to recover; brief hospitalization may even be needed. Although the illness is often over in a couple of weeks, fatigue can sometimes last two or three months, requiring extra rest. Careful monitoring by your healthcare provider is recommended.


UHS' Mono Clinic

Just been diagnosed with mono? Help yourself, help others and earn a stipend for your time by taking part in an important research project.

Mono is a common illness caused by the Epstein-Barr virus; because of its effects on the immune system, there is intense research interest in mono. UHS is participating in research led by the University of Massachusetts Medical School in Worcester which may lead to development of a vaccine.

Patients diagnosed with mono can be seen in the Mono Clinic and receive care from an experienced staff member. Those willing to participate in the study will donate blood and sputum samples during the acute illness and periodically during recovery. The first visit takes about a half-hour; remaining ones will be shorter. Compensation depends on the collection schedule assigned and ranges from $140 to $220.

To learn more or make an appointment, call or visit UHS’ General Medicine South, 577-5411.