B.S., The College of William & Mary,1995; M.S., University of Delaware, 2000; Ph.D., University of Maryland, 2008; Postdoctoral Fellowship, University of Maryland, 2010
Cardiovascular Disease, Exercise, Menopause, Regenerative Medicine
Dr. Witkowski's research interest is in conventional and novel risk factors for cardiovascular disease (CVD) and how they are influenced by physical activity, physical inactivity, and exercise. Recent research involves investigations of markers of cardiovascular disease such as endothelial dysfunction and adult stem cells known to contribute to the maintenance, regeneration, and blood vessel repair. Dr. Witkowski and her lab are interested in understanding how these tissues are influenced by environments related to CVD such as menopause and pro-inflammatory states and the mechanisms by which changes in physical activity behavior may alter the function of these tissues in these environments. Understanding the contribution of these tissues to cardiovascular health will help us understand cardiovascular disease and lead to optimization and personalization of prevention and treatment.
Sen S, Witkowski S, Lagoy, A, Islam I. A six-week home exercise program improves endothelial function and CD34+ circulating progenitor cells in patients with pre-diabetes. J Endocrinol Metab. 2015 Accepted.
LaBarbera KE, Hyldahl RD, O’Fallon KS, Clarkson PM, Witkowski S. Pericyte NF-κB activation enhances endothelial cell proliferation and proangiogenic cytokine secretion in vitro. Physiological Reports. 2015 Apr;3(4).
Guhanarayan G, Jablonski J, Witkowski S. Circulating Angiogenic Cell Population Responses to 10 Days of Reduced Physical Activity. J Appl Physiol (1985). 2014 Jul 10.
Witkowski S, Jenkins NT, Hagberg JM. Enhancing treatment for cardiovascular disease: Exercise and circulating angiogenic cells. Exerc Sport Sci Rev. 2011 Apr;39(2):93-101.
Witkowski S, Lockard MM, Jenkins NT, Obisesan TO, Spangenburg EE, Hagberg JM. Relationship between circulating progenitor cells to endothelial function and oxidative stress with long term training and short term detraining in older men. Clin Sci (Lond). 2010 Feb;118(4):303-11.