B.S., The College of William & Mary,1995; M.S., University of Delaware, 2000; Ph.D., University of Maryland, 2008; Postdoctoral Fellowship, University of Maryland, 2010
Cardiovascular Disease, Exercise, Diabetes, Regenerative Medicine
Dr. Witkowski's research interest is in conventional and novel risk factors for cardiovascular disease and how they are influenced by physical activity, physical inactivity, and exercise. Recent research involves investigations of markers of cardiovascular disease such as endothelial dysfunction and adult stem cells known to contribute to the maintenance, regeneration, and repair of the vascular endothelium. Dr. Witkowski and her lab are interested in understanding how these tissues are influenced by detrimental environments such as pro-inflammatory and hyperglycemic states and the mechanisms by which changes in physical activity behavior may alter the function of these tissues. Understanding the contribution of these tissues to cardiovascular health will help us understand cardiovascular disease and lead to optimization and personalization of prevention and treatment.
Ludlow AT, Witkowski S, Marshall MR, Wang J, Lima LCJ, Guth LM Spangenburg EE, Roth SM. Chronic exercise modifies age-related telomere dynamics in a tissue-specific fashion. J Gerontol A Biol Sci Med Sci. 2012 Mar 1.
Witkowski S, Jenkins NT, Hagberg JM. Enhancing treatment for cardiovascular disease: Exercise and circulating angiogenic cells. Exerc Sport Sci Rev. 2011 Apr;39(2):93-101.
Witkowski S, Lockard MM, Jenkins NT, Obisesan TO, Spangenburg EE, Hagberg JM. Relationship between circulating progenitor cells to endothelial function and oxidative stress with long term training and short term detraining in older men. Clin Sci (Lond). 2010 Feb;118(4):303-11.
Lockard MM, Witkowski S, Spangenburg EE, Jenkins NT, Obisesan TO, Hagberg JM. The Effect of Thrombin on Putative Endothelial Progenitor Cells with Exercise and Exercise Training. J Appl Physiol. 2010 Jun;108(6): 1682-90.
Jenkins NT, Witkowski S, Spangenburg EE, and Hagberg JM. Effects of acute and chronic endurance exercise on intracellular nitric oxide in putative endothelial progenitor cells: Role of NADPH oxidase. AJP Heart and Circulatory Physiology. 2009 Nov;297(5):H1798-805.