Richard J. Wood
B.A., Boston University; M.S., University of Connecticut; Ph.D., University of Connecticut; NIH Postdoctoral Fellowship, University of Chicago
vitamin D, calcium, bioactive food components, aging, obesity
Vitamin D can be converted in the body to biologically active metabolites, such as 1,25-dihydroxyvitamin D, that interact with nuclear transcription factors that lead to changes in gene expression and cell function. Research in Dr. Wood’s laboratory focuses on understanding the role of vitamin D as it relates to the molecular mechanisms associated with intestinal calcium transport, and more recently on fat cell function. In this context, the laboratory is also interested in the functional consequences of various genetic polymorphisms in genes associated with vitamin D signaling and diet-gene interactions. Recently, the laboratory has begun to explore the effects of various bioactive food components found in plant foods on cellular epigenetic changes in fat cells and intestinal cells and how these changes influence cellular vitamin D action.
Khan AH, Rohra DK, Saghir SA, Udani SK, Wood RJ, Jabbar A. No change in calcium absorption in adult Pakistani population before and after vitamin D administration using strontium as surrogate. Osteoporos Int 2012; May 10 [Epub ahead of print].
Cui M, Zhao Y, Hance KW, Shao A, Wood RJ, Fleet JC. Effects of MAPK signaling on 1,25-dihydroxyvitamin D-mediated CYP24 gene expression in the enterocyte-like cell line, Caco-2. J Cell Physiol. 2009; 219(1):132-42
Peters BSE, Santos LC, Fisberg M, Wood RJ, Martini LA. Prevalence of vitamin D insufficiency in Brazilian adolescents. Annals Nutr Metab 2009; 54:15-21.
Angelo G, Lamon-Fava S, Sonna LA, Lindauer ML, Wood RJ. Heat shock protein 90beta: a novel mediator of vitamin D action. Biochem Biophys Res Commun. 2008; 367(3):578-83.
Wood RJ, Tchack L, Angelo G, Pratt RE, Sonna LA. DNA microarray analysis of vitamin D-induced gene expression in human colon carcinoma cell line. Physiological Genomics. 2004; 17:122-129