B.S., University of Colorado; M.S., University of Colorado; Ph.D., University of Vermont; Post-Doctoral Fellowship, University of Vermont
Area(s) of Specialization:
Aging, Exercise, Skeletal Muscle, Muscle Mechanics, Sex Differences
My primary interest is investigating the effects of aging and exercise on human skeletal muscle in males and females at the whole body, tissue, single fiber and molecular levels. The goal is to understand how alterations at the molecular and single fiber levels affect whole muscle contraction in order to find potential sex-specific countermeasures to prevent the age-related loss of muscle performance. The laboratory combines the use of advanced engineering methods to measure muscle function at the molecular and single fiber levels with imaging techniques to examine muscle structure from the myofibril to the tissue level, biochemical techniques to quantify proteins as well as techniques to analyze the whole body skeletal muscle contractile performance.
Straight CR, Ades PA, Toth MJ, Miller MS. Age-related reduction in single muscle fiber calcium sensitivity is associated with decreased muscle power in men and women. Experimental Gerontology 102, 84-92, 2018.
Miller MS, Callahan DM, Tourville TW, Slauterbeck JR, Savage PD, Ades PA, Beynnon BD, Toth MJ. Moderate-intensity resistance exercise alters skeletal muscle molecular and cellular structure and function in inactive, older adults with knee osteoarthritis. Journal of Applied Physiology 122(4), 775-787, 2017. PMCID: PMC5407204
Miller MS, Bedrin NG, Ades PA, Palmer BM, Toth MJ. Molecular determinants of force production in human skeletal muscle fibers: Effects of myosin isoform expression and cross-sectional area. American Journal of Physiology - Cell Physiology 308(6), C473-C484, 2015. PMCID: PMC4360030
Callahan DM, Bedrin NG, Subramanian M, Berking J, Ades PA, Toth MJ, Miller MS. Age-related structural alterations in human skeletal muscle fibers and mitochondria are sex-specific: Relationship to single-fiber function. Journal of Applied Physiology 116(12), 1582-1592, 2014. PMCID: PMC4064376
Miller MS, Bedrin NG, Callahan DM, Previs MJ, Jennings II ME, Ades PA, Maughan DW, Palmer BM, Toth MJ. Age-related slowing of myosin actin cross-bridge kinetics is sex specific and predicts decrements in whole skeletal muscle performance in humans. Journal of Applied Physiology 115(7), 1004-1014, 2013. PMCID: PMC3798822