Mark S. Miller

Assistant Professor
106 Totman Building


B.S., University of Colorado; M.S., University of Colorado; Ph.D., University of Vermont; Post-Doctoral Fellowship, University of Vermont

Area(s) of Specialization: 

Aging, Exercise, Skeletal Muscle, Muscle Mechanics, Sex Differences

Research Description: 

My primary interest is investigating the effects of aging and exercise on human skeletal muscle in males and females at the whole body, tissue, single fiber and molecular levels. The goal is to understand how alterations at the molecular and single fiber levels affect whole muscle contraction in order to find potential sex-specific countermeasures to prevent the age-related loss of muscle performance. The laboratory combines the use of advanced engineering methods to measure muscle function at the molecular and single fiber levels with imaging techniques to examine muscle structure from the myofibril to the tissue level, biochemical techniques to quantify proteins as well as techniques to analyze the whole body skeletal muscle contractile performance.

Key Publications: 

Miller MS, Bedrin NG, Callahan DM, Previs MJ, Jennings II ME, Ades PA, Maughan DW, Palmer BM, Toth MJ. Age-related slowing of myosin actin cross-bridge kinetics is sex specific and predicts decrements in whole skeletal muscle performance in humans. Journal of Applied Physiology 115(7), 1004-1014, 2013. PMCID: PMC3798822

Callahan DM, Bedrin NG, Subramanian M, Berking J, Ades PA, Toth MJ, Miller MS. Age-related structural alterations in human skeletal muscle fibers and mitochondria are sex-specific: Relationship to single-fiber function. Journal of Applied Physiology 116(12), 1582-1592, 2014. PMCID: PMC4064376

Miller MS, Callahan DM, Toth MJ. Skeletal muscle myofilament adaptations to aging, disease and disuse and their effects on whole muscle performance in older adult humans. Frontiers in Physiology 5:369, 1-15, 2014. PMCID: PMC4176476

Miller MS, Toth MJ. Myofilament protein loss and dysfunction promote physical disability in aging and disease. Exercise and Sport Sciences Reviews 41(2), 93-99, 2013. PMCID: PMC4171103

Callahan DM, Miller MS, Sweeny AP, Tourville TW, Slauterbeck JR, Savage PD, Maughan DW, Ades PA, Beynnon BD, Toth MJ. Muscle disuse alters skeletal muscle contractile function at the molecular and cellular levels in older adult humans in a sex-specific manner. Journal of Physiology 592(20), 4555-4573, 2014. PMCID: PMC4287744