Laura N. Vandenberg
B.S., Cornell University, 2003; Ph.D., Tufts University School of Medicine, 2007; Postdoctoral Fellow & Research Associate, The Forsyth Institute Center for Regenerative & Developmental Biology and Harvard University School of Dental Medicine, 2007-2008; Postdoctoral Fellow, Tufts University, Department of Biology and Center for Regenerative & Developmental Biology, 2008-2013
endocrine disruptors, hazard assessment, developmental biology, endocrinology
My research explores how early life exposures to chemicals and chemical mixtures can predispose individuals to diseases that manifest later in life. Classical toxicology often focuses on how fetal chemical exposures can produce birth defects, an important part of chemical safety. My work instead addresses how low doses of chemicals during critical windows of development can alter gene expression, cell differentiation, and tissue organization in subtle ways that can lead to adult diseases such as cancer, obesity, and infertility. I am specifically interested in the class of chemicals termed ‘endocrine disruptors’ and have worked extensively with chemicals used as plasticizers and flame retardants. My work also focuses on how traditional toxicology assays have failed to identify a number of ubiquitous endocrine disruptors, and how current risk assessment practices can be improved in the study and regulation of this class of chemicals.
Catanese MC, Suvorov A, Vandenberg LN. 2015. Beyond a means of exposure: A new view of the mother in toxicology research. Toxicol Res 4:592-612.
Zoeller RT, Vandenberg LN. 2015. Assessing dose-response relationships for endocrine disrupting chemicals (EDCs): A focus on non-monotonicity. Environ Health 14:42.
Heindel JJ, Vandenberg LN. 2015. Developmental origins of health and disease: A paradigm for understanding disease etiology and prevention. Curr Opin Pediatr 27:248-253.
Vandenberg LN, Welshons WV, Vom Saal FS, Toutain PL, Myers JP. 2014. Should oral gavage be abandoned in toxicity testing of endocrine disruptors? Environ Health 13:46.
Vandenberg LN, Bowler AG. 2014. Non-monotonic dose responses in EDSP tier 1 guideline assays. Endocrine Disruptors 2:e964530.