Laura N. Vandenberg
B.S., Cornell University, 2003; Ph.D., Tufts University School of Medicine, 2007; Postdoctoral Fellow & Research Associate, The Forsyth Institute Center for Regenerative & Developmental Biology and Harvard University School of Dental Medicine, 2007-2008; Postdoctoral Fellow, Tufts University, Department of Biology and Center for Regenerative & Developmental Biology, 2008-2013
endocrine disruptors, hazard assessment, developmental biology, endocrinology
My research explores how early life exposures to chemicals and chemical mixtures can predispose individuals to diseases that manifest later in life. Classical toxicology often focuses on how fetal chemical exposures can produce birth defects, an important part of chemical safety. My work instead addresses how low doses of chemicals during critical windows of development can alter gene expression, cell differentiation, and tissue organization in subtle ways that can lead to adult diseases such as cancer, obesity, and infertility. I am specifically interested in the class of chemicals termed ‘endocrine disruptors’ and have worked extensively with chemicals used as plasticizers and flame retardants. My work also focuses on how traditional toxicology assays have failed to identify a number of ubiquitous endocrine disruptors, and how current risk assessment practices can be improved in the study and regulation of this class of chemicals.
Vandenberg LN, Welshons WV, vom Saal FS, Toutain PL, Myers JP. 2014. Should oral gavage be abandoned in toxicity testing of endocrine disruptors? Environmental Health. 13(1): 46.
Vandenberg LN, Catanese MC. 2014. Casting a wide net for endocrine disruptors. Chemistry & Biology. 21(6): 705-6.
Vandenberg LN, Gerona RR, Kannan K, Taylor JA, van Breemen RB, Dickenson CA, Liao C, Yuan Y, Newbold RR, Padmanabhan V, vom Saal FS, Woodruff TJ. 2014. A round robin approach to the analysis of bisphenol A (BPA) in human blood samples. Environmental Health 13(1): 25.
Vandenberg LN, Ehrlich S, Belcher SM, Ben-Jonathan N, Dolinoy DC, Hugo ER, Hunt PA, Newbold RR, Rubin BS, Saili KS, Soto AM, Wang HS, vom Saal FS. 2013. Low dose effects of bisphenol A: an integrated review of in vitro, laboratory animal and human studies. Endocrine Disruptors. 1(1): e1.1-e1.20.
Vandenberg LN, Hunt PA, Myers JP, vom Saal FS. 2013. Human exposures to bisphenol A: mismatches between data and assumptions. Reviews on Environmental Health. 28(1): 37-58.