B.A., California State University, Long Beach,1980; M.A., California State University, Long Beach, 1983; Ph.D., University of Southern California, 1987
skeletal muscle, fatigue, bioenergetics, aging, magnetic resonance spectroscopy
My primary interest is in the area of human skeletal muscle function and fatigue. In particular, our work examines the mechanisms of fatigue, and how these vary depending upon age, gender, chronic health status and habitual physical activity level. A related interest is an examination of the influence that fatigue has on functional capacity. We take a state-of-the-art, integrated approach to understanding human muscle function from the cell to the organism. The main problem we are working on now is how to minimize the loss of mobility and health that occur in old age.
Wigmore DM, BM Damon, DM Pober, JA Kent-Braun. MRI Measures of perfusion-related changes in human skeletal muscle during progressive contractions. J Appl Physiol 97:2385-94, 2004.
Lanza IR, RG Larsen, JA Kent-Braun. Effects of old age on skeletal muscle energetics during fatiguing contractions with and without blood flow. J Physiol 583(Pt 3):1093-105, 2007.
Callahan DM, Kent-Braun JA. Effect of old age on human skeletal muscle force-velocity and fatigue properties. J Appl Physiol. 2011 Nov;111(5):1345-52.
Larsen RG, Callahan DM, Foulis SA, Kent-Braun JA. Age-related changes in oxidative capacity differ between locomotory muscles and are associated with physical activity behavior. Appl Physiol Nutr Metab. 2012 Feb;37:88-99.
Kent-Braun JA, Fitts RH, Christie A. Skeletal muscle fatigue. Compr Physiol 2:997-1044, 2012.