Edward J. Calabrese
B.S., Bridgewater State, 1968; M.A., University of Massachusetts Amherst, 1972; Ph.D., University of Massachusetts Amherst, 1973; A.T.S.
toxicology, risk assessment, environmental health, dose response, hormesis
Over the past 20 years Professor Calabrese has redirected his research to understanding the nature of the dose response in the low dose zone and underlying adaptive explanatory mechanisms. Of particular note is that this research has led to important discoveries which indicate that the most fundamental dose response in toxicology and pharmacology is the hormetic-biphasic dose response relationship. These observations are leading to a major transformation in improving drug discovery, development, and in the efficiency of the clinical trial, as well as the scientific foundations for risk assessment and environmental regulation for radiation and chemicals.