B.A., University of Pennsylvania, 1982; M.S., University of Massachusetts Amherst, 1990; Ph.D., University of California, Berkeley, 1993; Post-doctoral Fellow, University of California, Berkeley, 1994-96; Post-doctoral Fellow and Asst. Director Nutrition Studies; Stanford University Medical School, 1996-99
Exercise, Diabetes, Energy Metabolism, Endocrinology
The primary mission of our Energy Metabolism Laboratory is "Metabolic Rehabilitation". To that end, we are trying to optimize the design of an exercise "drug" that will enhance metabolic health. We know that habitual exercise improves metabolic health and reduces risk for chronic disease. Habitual exercise is composed of frequent applications of individual exercise bouts. Therefore, each individual bout can be viewed as a drug; when taken at a sufficient dose, exercise has effects on metabolic health that peak and then diminishes over time, requiring subsequent doses to maintain the beneficial effects. In this context, each individual dose of exercise becomes important and tailoring the intensity, duration, nutritional environment and interactions with other medications to achieve the maximal benefit should have the biggest long-term impact on metabolic health. To optimally use exercise to minimize insulin resistance and prevent/manage Type-2 diabetes, we are working on:
- Better understanding the mechanisms by which exercise benefits metabolic health
- Determining how exercise interacts with energy balance and pharmacology
- Testing novel approaches; e.g. minimizing sitting, as potential strategies to enhance metabolic health with less time and effort than traditional exercise.
- Examining how activity and inactivity impact the hormonal regulation of appetite.
Malin SK, RG Gerber, SR Chipkin, B Braun. Independent and combined effects of exercise training and metformin on insulin sensitivity in individuals with prediabetes. Diabetes Care, 35:131-6, 2012.
Stephens BR, Granados K, Zderic TW, Hamilton MT, Braun B. Effects of one day of inactivity on insulin action in healthy men and women: interaction with energy intake. Metabolism: Clinical and Experimental 60:941-9, 2011.
Hagobian TA and B Braun. Physical Activity and Hormonal Regulation of Appetite: Sex Differences and Implications for Weight Control. Exerc. Sport Sci. Rev. 38:25-30, 2010.
Sharoff CG, TA Hagobian, SR Chipkin, H Yu, MF Hirshman, LJ Goodyear, B Braun. Combined effects of metformin and exercise on insulin action in insulin resistant individuals. Am. J. Physiol: Endocrinol. Metab. 298:E815-23, 2010.
Hagobian TA, Sharoff CG, Stephens BR, Wade GN, Chipkin SR, Silva EJ, Braun B. Effects of exercise on energy regulating hormones in men and women. Amer. J. Physiol: Comp. Reg. Physiol. 296: R233-42, 2009.