B.S., Moscow State Pedagogical University, 1990; Ph.D., Ecology and Evolution Institute of the Russian Academy of Sciences, 1994; Dr.Sci., Ecology and Evolution Institute of the Russian Academy of Sciences, 2006; Postdoctoral Research, Sherbrooke University, 2007-2010; Postdoctoral Research, Boston University, 2010-2013.
Developmental Toxicology, Epigenetics, Chromatin Structure, Endocrine Disruptors, Animal Models.
Environmental endocrine disruptors are a specific class of xenobiotics molecules that have the ability to interfere with endogenous hormonal signaling by a diverse array of molecular mechanisms. Exposure to these substances during critical periods of prenatal or neonatal life may cause permanent reprogramming of target tissues, likely epigenetic in nature, which often do not present immediate phenotypes but can ultimately lead to adulthood onset diseases.
Our main research interests consist in the study of toxicity of environmental endocrine disruptors in mammal models using a variety of approaches including traditional methods of toxicology as well as state of the art genomic (RNA-seq) and epigenetic methods (ChIP-seq, DHS-seq) which capitalize on recent advances in high throughput sequencing. In particular we focus on long-term reprogramming of metabolic and neuro-behavioral functions by developmental exposures to endocrine disruptors.
Suvorov A., Waxman D.J. 2013. Early Programming of Uterine Tissue by Bisphenol A: Evidence from Animal Exposure Studies, Environmental Health Perspectives, in press.
Suvorov A., Takser L. 2011. Delayed Frontal Lobes Transcriptome Response to Perinatal Exposure to BDE-47 in Rats. Journal of Applied Toxicology, 31(5):477-483.
Suvorov A., Takser L. 2010. Global Gene Expression Analysis in the Livers of Rat Offspring Perinatally Exposed to Low Doses of 2,2',4,4'-tetrabromodiphenyl ether. Environmental Health Perspectives, 118(1):97-102.
Suvorov A., Takser L. 2008. Facing the Challenge of Data Transfer from Animal Models to Humans: the Case of Persistent Organohalogens. Environ Health. 7(1):58.
Suvorov A., Girard S, Lachapelle S., Abdelouahab N., Sebire G., Takser L. 2008. Low-Dose BDE-47 and Hyperactivity in Rat Offspring. Neonatology, 95(3):203-209.