Dr. Young Cheul Kim
Name: Young-Cheul Kim
Title: Assistant Professor
Office: 206-B Chenoweth Lab
Phone: (413) 577-4553
Fax: (413) 545-1074
Email: yckim@nutrition.umass.edu
Education:
Ph.D., Nutrition Science, University of Tennessee
M.S., Food Science & Technology, Korea University
B.S., Biology, Keimyung University
Postdoc., Pharmacology & Biochemistry, Univ. of Wisconsin-Madison
Research Interests:
My research interest is to understand the impact of nutrients and dietary bioactive components (i.e., phenolic phytochemicals) on chronic diseases such as obesity and diabetes by identifying the molecular factors/pathways involved in fat cell differentiation and metabolism.
Selected Publications:
Davis J, Higginbotham A, O'connor T, Moustaid-Moussa N, Tebbe A, Kim Y-C et al. Soy Protein and Isoflavones Influence Adiposity and Development of Metabolic Syndrome in the Obese Male ZDF Rat. Ann Nutr Metab. 51: 42-52, 2007.
Kim KJ, Lee O-K, Lee HC, Kim Y-C, and Lee BY: (2007) Effect of Fucoidan on Expression of Diabetes Mellitus Related Genes in Mouse Adipocytes. Food Science and Biotechnology. Vol.16 No. 2, p49-54.
Kwon, Y-I., Apostolidis, E., Kim, Y-C. and Shetty, K. (2007) Health benefits of traditional corn, beans and pumpkin; In vitro studies for hyperglycemia and hypertension management. Journal of Medical Foods. 10(2): 266-275
Lee, OH, Kim Y-C, Kim, KJ, and Lee, BY: (2007) Effect of bioactive compounds and fatty acid composition on the oxidative stability of extra virgin olive oil varieties. Food Science and Biotechnology. Vol.16, No 3: 414-420
Zhao, D, Duan, H, Kim, Y-C, Jefcoate, CR. Rodent StAR mRNA is substantially regulated by control of mRNA stability through sites in the 3’-untranslated region and through coupling to ongoing transcription. Journal of Steroid Biochemistry & Molecular Biology. 96:155-173, 2005.
Kim, Y-C. Regulation of Fat Cell Development and Gene Expression. Proceeding of 4th International Symposium of APRC – Molecular Biology and Agriculture, pp1-8. 2003.
Gomez FE, Miyazaki M, Kim Y-C, Marwah P, Lardy HA, Ntambi JM, Fox B. Molecular differences caused by differentiation of 3T3-L1 preadipocytes in the presence of either dehydroepiandrosterone (DHEA) or 7-oxo-DHEA. Biochemistry. 41: 5473-5482, 2002.
Miyazaki, M, Kim, Y-C, and Ntambi, J.M. A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis. Journal of Lipid Research. 42: 1018-1024, 2001.
Ntambi, J.M. and Kim, Y-C. Regulation of the stearoyl-CoA desaturase genes by dietary fat: Role of polyunsaturated fatty acids. "Nutrient-Gene Interactions in Health and Disease". CRC Series in Modern Nutrition. pp49-61, 2001.
Kim, Y-C, Ntambi, J.M., Gomez, E., and Fox, B.G. Differential Regulation of the Stearoyl-CoA Desaturase Genes by Thiazolidinediones in 3T3-L1 Adipocytes. Journal of Lipid Research. 41 (8): 1310-1316, 2000.
Makoto, M, Kim, Y-C, Keller,M.P., Attie, A.D., and Ntambi, J.M.The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1. Journal of Biological Chemistry. 275 (39): 30132-30138, 2000.
Kim, Y-C and Ntambi, J.M. Regulation of Stearoyl-CoA Desaturase genes: Role in cellular metabolism and preadipocyte differentiation. Biochem. Biophys. Res. Comm. 266 (1): 1-4, 1999.
Recent Grants:
UMass,Faculty Research /Healey Endowment Grant
USDA CSREES, MAS00926
Teaching:
Basic Nutrition, Nutritional Biochemistry, Methods in Nutrition Research, Graduate & Undergraduate Nutrition Seminars
