Dr. Young Cheul Kim

 

   

Associate Professor

Telephone: (413) 577-4553

Fax: (413) 545-1074

Campus Address: 206-B Chenoweth Lab                                                         

Email: yckim@nutrition.umass.edu                                                         

                                                         

                                                         

 

Education:

            Ph.D., Nutrition Science, University of Tennessee

            M.S., Food Science & Technology, Korea University

            B.S., Biology, Keimyung University

            Postdoc., Pharmacology & Biochemistry, Univ. of Wisconsin-Madison

 

Research Interests:

My research interest is to understand the impact of nutrients and dietary bioactive components (i.e., phenolic phytochemicals) on chronic diseases such as obesity and diabetes by identifying the molecular factors/pathways involved in fat cell differentiation and metabolism.

 

Selected Publications:

 

Cho K, Kim YO, Andrade JE, Burgess JR, Kim Y-C. Dietary naringenin increases hepatic peroxisome proliferators-activated receptor a (PPARa) protein expression and decreases plasma triglyceride and adiposity in rats. European Journal of Nutrition. 50(2):81-88, 2011

 

Lee OH, Kwon Y-I, Apostolidis M, Shetty K, and Kim Y-C. Rhodiola-induced inhibition of adipogenesis involves antioxidant enzyme response associated with pentose phosphate pathway. Phytotherapy Research. 25(1):106-115, 2011

 

Cho KW, Lee OH, Banz WJ, Moustaid-Moussa N, Shay N. and Kim Y-C. Daidzein and the daidzein metabolite, equol, enhance adipocyte differentiation and PPARg transcriptional activity. Journal of Nutritional Biochemistry.Vol.21, 841-847, 2010

 

Lee OH, Seo DH, Park CS, Kim Y-C. Puerarin enhances adipocyte differentiation, adiponectin  expression, and antioxidant response in 3T3-L1 cells. Biofactors. 36(6):459-67, 2010

 

Park JY, Jung J, Seo, D, Ha S, Yoon J, Kim Y-C, Shim J, Park CS. Microbial production of palatinose through extracellular expression of a sucrose isomerase from Enterobacter sp. FMB-1 in Lactococcus lactis MG1363. Bioresource Technology. Vol. 101, 8823-8833, 2010

 

Kwon, Y-I., Apostolidis, E, Kim, Y-C and Shetty, K. Over-expression of proline-linked antioxidant pathway and modulation of phenolic metabolites in long life span clonal line of origanum vulgare in response to UV-radiation. Journal of Food Biochemistry. 33(5):649-673, 2009.

 

Lee, OH, Lee, BY, Lee, J, Lee, HB, Son, JY, Park, CS, Shetty, K, and Kim, Y-C.  Assessment of Phenolics-Enriched Extract and Fractions of Olive Leaves and Their Antioxidant Activities. Bioresources Technology, 100:6107-6113, 2009.

Cha J, Jung JH, Park SE, Cho MH, Seo DH, Ha SJ, Yoon JW, Lee OH, Kim, Y-C, Park, CS. Molecular cloning and functional characterization of a sucrose isomerase gene from Enterobacter sp. FMB-1. Journal of Applied Mircrobiology, 107(4):1119-30, 2009.

 

Lee, OH, Kwon, YI, Lee, BY, Hong, HD, Park, CS, and Kim, Y-C. Production of Reactive Oxygen Species and Changes in Antioxidant Enzyme Activities during Differentiation of 3T3-L1 Adipocyte. J. Kor. Soc. Appl. Biol. Chem. Vol. 52(1), 70-75, 2009.

 

Shim, SM, Ferruzzi, MG, Kim, Y-C, Janle ER, and Santerre, CR. Impact of foods on the bioavailabitity of methylmercury in a Caco-2 human intestinal cell model. Food Chemistry. Vol. 112. 46-50, 2009.

 

Lee, OH, Lee, BY, Kim, C, Shetty, K, and Kim, Y-C. Radical Scavenging-linked   Antioxidant Activity of Ethanolic Extracts of Diverse Types of Extra Virgin Olive Oils. Journal of Food Science. Vol.73(7). C519-25,  2008.

 

Davis J, Higginbotham A, O'connor T, Moustaid-Moussa N, Tebbe A, Kim Y-C et al. Soy Protein and Isoflavones Influence Adiposity and Development of Metabolic Syndrome in the Obese Male ZDF Rat. Ann Nutr Metab. 51: 42-52, 2007.

 

Kim KJ, Lee O-K, Lee HC, Kim Y-C, and Lee BY. Effect of Fucoidan on Expression of Diabetes Mellitus Related Genes in Mouse Adipocytes. Food Science and Biotechnology. Vol.16 No. 2, p49-54, 2007.

 

Kwon, Y-I., Apostolidis, E., Kim, Y-C. and Shetty, K. Health benefits of traditional corn, beans and pumpkin; In vitro studies for hyperglycemia and hypertension management. Journal of Medicinal Foods. 10(2): 266-275, 2007

 

Cha J, Jung JH, Park SE, Cho MH, Seo DH, Ha SJ, Yoon JW, Lwee OH, Kim, Y-C, Park, CS. Molecular cloning and functional characterization of a sucrose isomerase (isomaltulose synthase) gene from Enterobacter sp. FMB-1. Journal of Applied Mircrobiology, March, 1335-2672.2007.

 

Lee, OH, Kim Y-C, Kim, KJ, and Lee, BY. Effect of bioactive compounds    and fatty acid composition on the oxidative stability of extra virgin olive oil varieties. Food Science and Biotechnology. Vol.16, No 3: 414-420, 2007.

 

Zhao, D, Duan, H, Kim, Y-C, Jefcoate, CR. Rodent StAR mRNA is substantially regulated by control of mRNA stability through sites in the 3’-untranslated region and through coupling to ongoing transcription. Journal of Steroid Biochemistry & Molecular Biology. 96:155-173, 2005.

 

Kim, Y-C. Regulation of Fat Cell Development and Gene Expression. Proceeding of 4th International Symposium of APRC – Molecular Biology and Agriculture, pp1-8. 2003.

 

Gomez FE, Miyazaki M, Kim Y-C, Marwah P, Lardy HA, Ntambi JM, Fox B. Molecular differences caused by differentiation of 3T3-L1 preadipocytes in the presence of either dehydroepiandrosterone (DHEA) or 7-oxo-DHEA.  Biochemistry. 41: 5473-5482, 2002.

 

Miyazaki, M, Kim, Y-C, and Ntambi, J.M. A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis.  Journal of Lipid Research. 42: 1018-1024, 2001.

 

Ntambi, J.M. and Kim, Y-C. Regulation of the stearoyl-CoA desaturase genes by dietary fat: Role of polyunsaturated fatty acids. "Nutrient-Gene Interactions in Health and Disease". CRC Series in Modern Nutrition. 49-61, 2001.

 

Kim, Y-C, Ntambi, J.M., Gomez, E., and Fox, B.G. Differential Regulation of the Stearoyl-CoA Desaturase Genes by Thiazolidinediones in 3T3-L1 Adipocytes. Journal of Lipid Research.  41 (8): 1310-1316, 2000.

 

Ntambi, J.M. and Kim, Y-C: (2000) Adipocyte differentiation and gene expression. Journal of Nutrition.  130: 3122S-3126S.

 

Choi, Y, Kim, Y-C, Han, Y-B., Park, Y., Pariza, M.W., and Ntambi, J.M.: (2000) The trans-10, cis-12 isomer of conjugated linoleic acid downregulates stearoyl-CoA desaturase gene expression in 3T3-L1 adipocytes. Journal of Nutrition.  130: 1920-1924.

 

Makoto, M, Kim, Y-C, Keller,M.P., Attie, A.D., and Ntambi, J.M.The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1. Journal of Biological Chemistry. 275 (39): 30132-30138, 2000.

 

Kim, Y-C and Ntambi, J.M. Regulation of Stearoyl-CoA Desaturase genes: Role in cellular metabolism and preadipocyte differentiation. Biochem. Biophys. Res. Comm. 266 (1): 1-4, 1999.

 

 

 

Recent Grants:

UMass,Faculty Research /Healey Endowment Grant

USDA CSREES, MAS00926

 

Teaching:

Basic Nutrition, Nutritional Biochemistry, Nutrition and Chronic Diseases, Methods in Nutrition Research, Graduate & Undergraduate Nutrition Seminars.